Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IRF6 (interferon regulatory factor 6)

Identity

Other namesLPS
OFC6
PIT
PPS
PPS1
VWS
VWS1
HGNC (Hugo) IRF6
LocusID (NCBI) 3664
Location 1q32.2
Location_base_pair Starts at 209958968 and ends at 209979520 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)IRF6   6121
Entrez_Gene (NCBI)IRF6  3664  interferon regulatory factor 6
Cards
GeneCards (Weizmann)IRF6
Ensembl (Hinxton)ENSG00000117595 [Gene_View]  chr1:209958968-209979520 [Contig_View]  IRF6 [Vega]
AceView (NCBI)IRF6
Genatlas (Paris)IRF6
SOURCE (Stanford)NM_001206696 NM_006147
Genomic and cartography
GoldenPath (UCSC)IRF6  -  1q32.2   chr1:209958968-209979520 -  1q32.2   [Description]    (hg19-Feb_2009)
EnsemblIRF6 - 1q32.2 [CytoView]
Mapping of homologs : NCBIIRF6 [Mapview]
OMIM119300   119500   607199   608864   
Gene and transcription
Genbank (Entrez)AF027292 AK296960 AK312857 BC014852 BI770148
RefSeq transcript (SRS)NM_001206696 NM_006147
RefSeq transcript (Entrez)NM_001206696 NM_006147
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NG_007081 NT_167186 NW_001838537 NW_004078000
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007081 NT_167186 NW_001838537 NW_004078000
Consensus coding sequences : CCDS (NCBI)IRF6
Cluster EST : UnigeneHs.591415 [ SRS ] Hs.591415 [ NCBI ]
CGAP (NCI)Hs.591415
Alternative Splicing : Fast-db (Paris)GSHG0002930
Alternative Splicing GalleryENSG00000117595
Gene ExpressionIRF6 [ NCBI-GEO ]   IRF6 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14896 (SRS) O14896 (Uniprot)
NextProtO14896
With graphics : InterProO14896
Splice isoforms : SwissVarO14896(Swissvar)
Domaine pattern : Prosite (SRS)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (SRS)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    SMAD_dom-like    SMAD_FHA_domain    WHTH_trsnscrt_rep_DNA-bd   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    SMAD_dom-like    SMAD_FHA_domain    WHTH_trsnscrt_rep_DNA-bd   
Related proteins : CluSTrO14896
Domain families : Pfam (SRS)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (Sanger)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (NCBI)pfam00605    pfam10401   
Domain families : Smart (EMBL)IRF (SM00348)  
DMDM3664
Blocks (Seattle)O14896
Human Protein AtlasENSG00000117595
HPRD06227
IPIIPI00024290   IPI01012366   IPI00645422   
Protein Interaction databases
DIP (DOE-UCLA)O14896
IntAct (EBI)O14896
FunCoupENSG00000117595
REACTOMEIRF6
Protein Interaction Database3664
BioGRIDIRF6
InParanoidO14896
Interologous Interaction database O14896
IntegromeDBIRF6
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IRF6
SNP (GeneSNP Utah)IRF6
SNP : HGBaseIRF6
Genetic variants : HAPMAPIRF6
Somatic Mutations in Cancer : COSMICIRF6 
CONAN: Copy Number AnalysisIRF6 
Mutations and Diseases : HGMDIRF6
OMIM119300    119500    607199    608864   
GENETests119300    119500    607199    608864   
Disease Genetic AssociationIRF6
Huge Navigator IRF6 [HugePedia]  IRF6 [HugeCancerGEM]
Genomic VariantsIRF6  IRF6 [DGVbeta]
snp3D : Map Gene to Disease3664
General knowledge
Homologs : HomoloGeneIRF6
Homology/Alignments : Family Browser (UCSC)IRF6
Phylogenetic Trees/Animal Genes : TreeFamIRF6
Chemical/Protein Interactions : CTD3664
Chemical/Pharm GKB GenePA29920
Clinical trialIRF6
Cancer Resource (Charite)ENSG00000117595
Ontology : AmiGOregulatory region DNA binding  DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-dependent  cell cycle arrest  negative regulation of cell proliferation  cytokine-mediated signaling pathway  keratinocyte differentiation  skin development  keratinocyte proliferation  positive regulation of transcription, DNA-dependent  cell development  interferon-gamma-mediated signaling pathway  type I interferon-mediated signaling pathway  mammary gland epithelial cell differentiation  
Ontology : EGO-EBIregulatory region DNA binding  DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  cytoplasm  cytosol  transcription, DNA-dependent  cell cycle arrest  negative regulation of cell proliferation  cytokine-mediated signaling pathway  keratinocyte differentiation  skin development  keratinocyte proliferation  positive regulation of transcription, DNA-dependent  cell development  interferon-gamma-mediated signaling pathway  type I interferon-mediated signaling pathway  mammary gland epithelial cell differentiation  
Other databases
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
PubGeneIRF6
iHOPIRF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:24:41 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.