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IRF8 (interferon regulatory factor 8)

Identity

Alias_namesICSBP1
interferon consensus sequence binding protein 1
Alias_symbol (synonym)IRF-8
ICSBP
Other aliasH-ICSBP
IMD32A
IMD32B
HGNC (Hugo) IRF8
LocusID (NCBI) 3394
Atlas_Id 50137
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 85899168 and ends at 85922605 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IGH (14q32.33) / IRF8 (16q24.1)IRF8 (16q24.1) / MRPL14 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Pediatric-type Follicular Lymphoma


External links

Nomenclature
HGNC (Hugo)IRF8   5358
LRG (Locus Reference Genomic)LRG_294
Cards
Entrez_Gene (NCBI)IRF8  3394  interferon regulatory factor 8
AliasesH-ICSBP; ICSBP; ICSBP1; IMD32A; 
IMD32B; IRF-8
GeneCards (Weizmann)IRF8
Ensembl hg19 (Hinxton)ENSG00000140968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140968 [Gene_View]  chr16:85899168-85922605 [Contig_View]  IRF8 [Vega]
ICGC DataPortalENSG00000140968
TCGA cBioPortalIRF8
AceView (NCBI)IRF8
Genatlas (Paris)IRF8
WikiGenes3394
SOURCE (Princeton)IRF8
Genetics Home Reference (NIH)IRF8
Genomic and cartography
GoldenPath hg38 (UCSC)IRF8  -     chr16:85899168-85922605 +  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRF8  -     16q24.1   [Description]    (hg19-Feb_2009)
EnsemblIRF8 - 16q24.1 [CytoView hg19]  IRF8 - 16q24.1 [CytoView hg38]
Mapping of homologs : NCBIIRF8 [Mapview hg19]  IRF8 [Mapview hg38]
OMIM601565   614893   614894   
Gene and transcription
Genbank (Entrez)AA232881 AI307662 AK313524 BC126247 BF110315
RefSeq transcript (Entrez)NM_002163
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRF8
Cluster EST : UnigeneHs.137427 [ NCBI ]
CGAP (NCI)Hs.137427
Alternative Splicing GalleryENSG00000140968
Gene ExpressionIRF8 [ NCBI-GEO ]   IRF8 [ EBI - ARRAY_EXPRESS ]   IRF8 [ SEEK ]   IRF8 [ MEM ]
Gene Expression Viewer (FireBrowse)IRF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3394
GTEX Portal (Tissue expression)IRF8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02556   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02556  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02556
Splice isoforms : SwissVarQ02556
PhosPhoSitePlusQ02556
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    SMAD_dom-like    SMAD_FHA_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (NCBI)pfam00605    pfam10401   
Domain families : Smart (EMBL)IRF (SM00348)  IRF-3 (SM01243)  
Conserved Domain (NCBI)IRF8
DMDM Disease mutations3394
Blocks (Seattle)IRF8
SuperfamilyQ02556
Human Protein AtlasENSG00000140968
Peptide AtlasQ02556
HPRD03336
IPIIPI00026224   
Protein Interaction databases
DIP (DOE-UCLA)Q02556
IntAct (EBI)Q02556
FunCoupENSG00000140968
BioGRIDIRF8
STRING (EMBL)IRF8
ZODIACIRF8
Ontologies - Pathways
QuickGOQ02556
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  transcription, DNA-templated  phagocytosis  immune response  myeloid cell differentiation  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  defense response to bacterium  defense response to protozoan  negative regulation of growth of symbiont in host  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  cellular response to lipopolysaccharide  cellular response to interferon-gamma  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  transcription, DNA-templated  phagocytosis  immune response  myeloid cell differentiation  positive regulation of interferon-gamma production  positive regulation of interleukin-12 production  defense response to bacterium  defense response to protozoan  negative regulation of growth of symbiont in host  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  cellular response to lipopolysaccharide  cellular response to interferon-gamma  
Pathways : KEGGPertussis   
NDEx NetworkIRF8
Atlas of Cancer Signalling NetworkIRF8
Wikipedia pathwaysIRF8
Orthology - Evolution
OrthoDB3394
GeneTree (enSembl)ENSG00000140968
Phylogenetic Trees/Animal Genes : TreeFamIRF8
HOVERGENQ02556
HOGENOMQ02556
Homologs : HomoloGeneIRF8
Homology/Alignments : Family Browser (UCSC)IRF8
Gene fusions - Rearrangements
Fusion : MitelmanIGH/IRF8 [14q32.33/16q24.1]  [t(14;16)(q32;q24)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF8
dbVarIRF8
ClinVarIRF8
1000_GenomesIRF8 
Exome Variant ServerIRF8
ExAC (Exome Aggregation Consortium)IRF8 (select the gene name)
Genetic variants : HAPMAP3394
Genomic Variants (DGV)IRF8 [DGVbeta]
DECIPHERIRF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRF8 
Mutations
ICGC Data PortalIRF8 
TCGA Data PortalIRF8 
Broad Tumor PortalIRF8
OASIS PortalIRF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRF8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRF8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IRF8
DgiDB (Drug Gene Interaction Database)IRF8
DoCM (Curated mutations)IRF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRF8 (select a term)
intoGenIRF8
Cancer3DIRF8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601565    614893    614894   
Orphanet21680   
MedgenIRF8
Genetic Testing Registry IRF8
NextProtQ02556 [Medical]
TSGene3394
GENETestsIRF8
Target ValidationIRF8
Huge Navigator IRF8 [HugePedia]
snp3D : Map Gene to Disease3394
BioCentury BCIQIRF8
ClinGenIRF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3394
Chemical/Pharm GKB GenePA29606
Clinical trialIRF8
Miscellaneous
canSAR (ICR)IRF8 (select the gene name)
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRF8
EVEXIRF8
GoPubMedIRF8
iHOPIRF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:48 CEST 2017

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