Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IRGM (immunity related GTPase M)

Identity

Alias_namesIRGM1
immunity-related GTPase family
Alias_symbol (synonym)LRG47
LRG-47
IFI1
Other alias
HGNC (Hugo) IRGM
LocusID (NCBI) 345611
Atlas_Id 52901
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 150846523 and ends at 150902402 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRGM   29597
Cards
Entrez_Gene (NCBI)IRGM  345611  immunity related GTPase M
AliasesIFI1; IRGM1; LRG-47; LRG47
GeneCards (Weizmann)IRGM
Ensembl hg19 (Hinxton)ENSG00000237693 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000237693 [Gene_View]  chr5:150846523-150902402 [Contig_View]  IRGM [Vega]
ICGC DataPortalENSG00000237693
TCGA cBioPortalIRGM
AceView (NCBI)IRGM
Genatlas (Paris)IRGM
WikiGenes345611
SOURCE (Princeton)IRGM
Genetics Home Reference (NIH)IRGM
Genomic and cartography
GoldenPath hg38 (UCSC)IRGM  -     chr5:150846523-150902402 +  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRGM  -     5q33.1   [Description]    (hg19-Feb_2009)
EnsemblIRGM - 5q33.1 [CytoView hg19]  IRGM - 5q33.1 [CytoView hg38]
Mapping of homologs : NCBIIRGM [Mapview hg19]  IRGM [Mapview hg38]
OMIM607948   608212   612278   612279   
Gene and transcription
Genbank (Entrez)BC038539 BC128167 BC128168 EU742619
RefSeq transcript (Entrez)NM_001145805 NM_001346557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRGM
Cluster EST : UnigeneHs.652148 [ NCBI ]
CGAP (NCI)Hs.652148
Alternative Splicing GalleryENSG00000237693
Gene ExpressionIRGM [ NCBI-GEO ]   IRGM [ EBI - ARRAY_EXPRESS ]   IRGM [ SEEK ]   IRGM [ MEM ]
Gene Expression Viewer (FireBrowse)IRGM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)345611
GTEX Portal (Tissue expression)IRGM
Human Protein AtlasENSG00000237693-IRGM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA1A4Y4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA1A4Y4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA1A4Y4
Splice isoforms : SwissVarA1A4Y4
Catalytic activity : Enzyme3.6.5.- [ Enzyme-Expasy ]   3.6.5.-3.6.5.- [ IntEnz-EBI ]   3.6.5.- [ BRENDA ]   3.6.5.- [ KEGG ]   
PhosPhoSitePlusA1A4Y4
Domaine pattern : Prosite (Expaxy)G_IRG (PS51716)   
Domains : Interpro (EBI)G_IRG_dom    Immunity-related_GTPase-like    P-loop_NTPase   
Domain families : Pfam (Sanger)IIGP (PF05049)   
Domain families : Pfam (NCBI)pfam05049   
Conserved Domain (NCBI)IRGM
DMDM Disease mutations345611
Blocks (Seattle)IRGM
SuperfamilyA1A4Y4
Human Protein Atlas [tissue]ENSG00000237693-IRGM [tissue]
Peptide AtlasA1A4Y4
IPIIPI00235330   IPI00746045   IPI00977535   
Protein Interaction databases
DIP (DOE-UCLA)A1A4Y4
IntAct (EBI)A1A4Y4
FunCoupENSG00000237693
BioGRIDIRGM
STRING (EMBL)IRGM
ZODIACIRGM
Ontologies - Pathways
QuickGOA1A4Y4
Ontology : AmiGOautophagosome assembly  Golgi membrane  autophagosome membrane  phagocytic cup  positive regulation of protein phosphorylation  protein binding  GTP binding  mitochondrion  Golgi apparatus  cytosol  inflammatory response  positive regulation of autophagy  positive regulation of peptidyl-threonine phosphorylation  hydrolase activity  protein kinase binding  phagocytic vesicle membrane  protein destabilization  positive regulation of peptidyl-serine phosphorylation  defense response to bacterium  cell projection  regulation of protein complex assembly  protein serine/threonine kinase activator activity  innate immune response  CARD domain binding  protein stabilization  defense response to Gram-negative bacterium  BH3 domain binding  positive regulation of interferon-gamma-mediated signaling pathway  regulation of protein complex stability  protein lipidation involved in autophagosome assembly  CAMKK-AMPK signaling cascade  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to lipopolysaccharide  positive regulation of protein serine/threonine kinase activity  autophagy of host cells involved in interaction with symbiont  cellular response to virus  positive regulation of autophagosome maturation  
Ontology : EGO-EBIautophagosome assembly  Golgi membrane  autophagosome membrane  phagocytic cup  positive regulation of protein phosphorylation  protein binding  GTP binding  mitochondrion  Golgi apparatus  cytosol  inflammatory response  positive regulation of autophagy  positive regulation of peptidyl-threonine phosphorylation  hydrolase activity  protein kinase binding  phagocytic vesicle membrane  protein destabilization  positive regulation of peptidyl-serine phosphorylation  defense response to bacterium  cell projection  regulation of protein complex assembly  protein serine/threonine kinase activator activity  innate immune response  CARD domain binding  protein stabilization  defense response to Gram-negative bacterium  BH3 domain binding  positive regulation of interferon-gamma-mediated signaling pathway  regulation of protein complex stability  protein lipidation involved in autophagosome assembly  CAMKK-AMPK signaling cascade  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to lipopolysaccharide  positive regulation of protein serine/threonine kinase activity  autophagy of host cells involved in interaction with symbiont  cellular response to virus  positive regulation of autophagosome maturation  
NDEx NetworkIRGM
Atlas of Cancer Signalling NetworkIRGM
Wikipedia pathwaysIRGM
Orthology - Evolution
OrthoDB345611
GeneTree (enSembl)ENSG00000237693
Phylogenetic Trees/Animal Genes : TreeFamIRGM
HOVERGENA1A4Y4
HOGENOMA1A4Y4
Homologs : HomoloGeneIRGM
Homology/Alignments : Family Browser (UCSC)IRGM
Gene fusions - Rearrangements
Fusion : QuiverIRGM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRGM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRGM
dbVarIRGM
ClinVarIRGM
1000_GenomesIRGM 
Exome Variant ServerIRGM
ExAC (Exome Aggregation Consortium)ENSG00000237693
GNOMAD BrowserENSG00000237693
Genetic variants : HAPMAP345611
Genomic Variants (DGV)IRGM [DGVbeta]
DECIPHERIRGM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRGM 
Mutations
ICGC Data PortalIRGM 
TCGA Data PortalIRGM 
Broad Tumor PortalIRGM
OASIS PortalIRGM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRGM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRGM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IRGM
DgiDB (Drug Gene Interaction Database)IRGM
DoCM (Curated mutations)IRGM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRGM (select a term)
intoGenIRGM
Cancer3DIRGM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607948    608212    612278    612279   
Orphanet
DisGeNETIRGM
MedgenIRGM
Genetic Testing Registry IRGM
NextProtA1A4Y4 [Medical]
TSGene345611
GENETestsIRGM
Target ValidationIRGM
Huge Navigator IRGM [HugePedia]
snp3D : Map Gene to Disease345611
BioCentury BCIQIRGM
ClinGenIRGM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD345611
Chemical/Pharm GKB GenePA142671652
Clinical trialIRGM
Miscellaneous
canSAR (ICR)IRGM (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRGM
EVEXIRGM
GoPubMedIRGM
iHOPIRGM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:18:23 CET 2018

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