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IRS4 (insulin receptor substrate 4)

Identity

Alias_symbol (synonym)PY160
IRS-4
Other alias
HGNC (Hugo) IRS4
LocusID (NCBI) 8471
Atlas_Id 43671
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 108732497 and ends at 108736377 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRB () / IRS4 (Xq22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;7)(q22;q34) IRS4/TRB


External links

Nomenclature
HGNC (Hugo)IRS4   6128
Cards
Entrez_Gene (NCBI)IRS4  8471  insulin receptor substrate 4
AliasesIRS-4; PY160
GeneCards (Weizmann)IRS4
Ensembl hg19 (Hinxton)ENSG00000133124 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133124 [Gene_View]  chrX:108732497-108736377 [Contig_View]  IRS4 [Vega]
ICGC DataPortalENSG00000133124
TCGA cBioPortalIRS4
AceView (NCBI)IRS4
Genatlas (Paris)IRS4
WikiGenes8471
SOURCE (Princeton)IRS4
Genetics Home Reference (NIH)IRS4
Genomic and cartography
GoldenPath hg38 (UCSC)IRS4  -     chrX:108732497-108736377 -  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRS4  -     Xq22.3   [Description]    (hg19-Feb_2009)
EnsemblIRS4 - Xq22.3 [CytoView hg19]  IRS4 - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBIIRS4 [Mapview hg19]  IRS4 [Mapview hg38]
OMIM300904   
Gene and transcription
Genbank (Entrez)AF007567 AL832136 BC156188 BC156977
RefSeq transcript (Entrez)NM_003604
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRS4
Cluster EST : UnigeneHs.460872 [ NCBI ]
CGAP (NCI)Hs.460872
Alternative Splicing GalleryENSG00000133124
Gene ExpressionIRS4 [ NCBI-GEO ]   IRS4 [ EBI - ARRAY_EXPRESS ]   IRS4 [ SEEK ]   IRS4 [ MEM ]
Gene Expression Viewer (FireBrowse)IRS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8471
GTEX Portal (Tissue expression)IRS4
Human Protein AtlasENSG00000133124-IRS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14654   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14654  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14654
Splice isoforms : SwissVarO14654
PhosPhoSitePlusO14654
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)IRS_PTB    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)IRS (PF02174)   
Domain families : Pfam (NCBI)pfam02174   
Domain families : Smart (EMBL)PH (SM00233)  PTBI (SM00310)  
Conserved Domain (NCBI)IRS4
DMDM Disease mutations8471
Blocks (Seattle)IRS4
SuperfamilyO14654
Human Protein Atlas [tissue]ENSG00000133124-IRS4 [tissue]
Peptide AtlasO14654
HPRD04620
IPIIPI00020729   
Protein Interaction databases
DIP (DOE-UCLA)O14654
IntAct (EBI)O14654
FunCoupENSG00000133124
BioGRIDIRS4
STRING (EMBL)IRS4
ZODIACIRS4
Ontologies - Pathways
QuickGOO14654
Ontology : AmiGOsignal transducer activity  SH3/SH2 adaptor activity  insulin receptor binding  protein binding  cytosol  plasma membrane  plasma membrane  signal transduction  insulin receptor signaling pathway  positive regulation of signal transduction  regulation of lipid metabolic process  phosphatidylinositol 3-kinase binding  
Ontology : EGO-EBIsignal transducer activity  SH3/SH2 adaptor activity  insulin receptor binding  protein binding  cytosol  plasma membrane  plasma membrane  signal transduction  insulin receptor signaling pathway  positive regulation of signal transduction  regulation of lipid metabolic process  phosphatidylinositol 3-kinase binding  
Pathways : KEGGFoxO signaling pathway    Insulin signaling pathway    Adipocytokine signaling pathway    Type II diabetes mellitus   
NDEx NetworkIRS4
Atlas of Cancer Signalling NetworkIRS4
Wikipedia pathwaysIRS4
Orthology - Evolution
OrthoDB8471
GeneTree (enSembl)ENSG00000133124
Phylogenetic Trees/Animal Genes : TreeFamIRS4
HOVERGENO14654
HOGENOMO14654
Homologs : HomoloGeneIRS4
Homology/Alignments : Family Browser (UCSC)IRS4
Gene fusions - Rearrangements
Fusion : MitelmanTRB/IRS4 [-/Xq22.3]  [t(X;7)(q22;q34)]  
Tumor Fusion PortalIRS4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRS4
dbVarIRS4
ClinVarIRS4
1000_GenomesIRS4 
Exome Variant ServerIRS4
ExAC (Exome Aggregation Consortium)ENSG00000133124
GNOMAD BrowserENSG00000133124
Genetic variants : HAPMAP8471
Genomic Variants (DGV)IRS4 [DGVbeta]
DECIPHERIRS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRS4 
Mutations
ICGC Data PortalIRS4 
TCGA Data PortalIRS4 
Broad Tumor PortalIRS4
OASIS PortalIRS4 [ Somatic mutations - Copy number]
Cancer Gene: CensusIRS4 
Somatic Mutations in Cancer : COSMICIRS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch IRS4
DgiDB (Drug Gene Interaction Database)IRS4
DoCM (Curated mutations)IRS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRS4 (select a term)
intoGenIRS4
Cancer3DIRS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300904   
Orphanet
DisGeNETIRS4
MedgenIRS4
Genetic Testing Registry IRS4
NextProtO14654 [Medical]
TSGene8471
GENETestsIRS4
Target ValidationIRS4
Huge Navigator IRS4 [HugePedia]
snp3D : Map Gene to Disease8471
BioCentury BCIQIRS4
ClinGenIRS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8471
Chemical/Pharm GKB GenePA29923
Clinical trialIRS4
Miscellaneous
canSAR (ICR)IRS4 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRS4
EVEXIRS4
GoPubMedIRS4
iHOPIRS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:07 CET 2017

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