IRX1 (iroquois homeobox 1)

2008-09-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
IRX-5,IRXA1

Other Information

Locus ID:

NCBI: 79192
MIM: 606197
HGNC: 14358
Ensembl: ENSG00000170549

Variants:

dbSNP: 79192
ClinVar: 79192
TCGA: ENSG00000170549
COSMIC: IRX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170549ENST00000302006P78414

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
185594912008Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma.50
184210762008A genome-wide scan maps a novel high myopia locus to 5p15.38
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.36
258220252015IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.29
204402642010Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.28
204402642010Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.28
200299862010HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.19
216028942011IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.19
234562992013Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.8

Citation

Dessen P

IRX1 (iroquois homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50333/irx1