IRX2 (iroquois homeobox 2)

2007-02-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
IRXA2
FUSION GENES

Other Information

Locus ID:

NCBI: 153572
MIM: 606198
HGNC: 14359
Ensembl: ENSG00000170561

Variants:

dbSNP: 153572
ClinVar: 153572
TCGA: ENSG00000170561
COSMIC: IRX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170561ENST00000302057Q9BZI1
ENSG00000170561ENST00000382611Q9BZI1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222108792012Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.41
184210762008A genome-wide scan maps a novel high myopia locus to 5p15.38
167523832006Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.13
248063322014Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway.6
260625232015IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.6
265604782015Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.5

Citation

Dessen P

IRX2 (iroquois homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45962/irx2