Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IRX2 (iroquois homeobox 2)

Identity

Alias (NCBI)IRXA2
HGNC (Hugo) IRX2
LocusID (NCBI) 153572
Atlas_Id 45962
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 2746165 and ends at 2751677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARFRP1 (20q13.33)::IRX2 (5p15.33)IRX2 (5p15.33)::TERT (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IRX2   14359
Cards
Entrez_Gene (NCBI)IRX2    iroquois homeobox 2
AliasesIRXA2
GeneCards (Weizmann)IRX2
Ensembl hg19 (Hinxton)ENSG00000170561 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170561 [Gene_View]  ENSG00000170561 [Sequence]  chr5:2746165-2751677 [Contig_View]  IRX2 [Vega]
ICGC DataPortalENSG00000170561
TCGA cBioPortalIRX2
AceView (NCBI)IRX2
Genatlas (Paris)IRX2
SOURCE (Princeton)IRX2
Genetics Home Reference (NIH)IRX2
Genomic and cartography
GoldenPath hg38 (UCSC)IRX2  -     chr5:2746165-2751677 -  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRX2  -     5p15.33   [Description]    (hg19-Feb_2009)
GoldenPathIRX2 - 5p15.33 [CytoView hg19]  IRX2 - 5p15.33 [CytoView hg38]
ImmunoBaseENSG00000170561
Genome Data Viewer NCBIIRX2 [Mapview hg19]  
OMIM606198   
Gene and transcription
Genbank (Entrez)AB188492 AI131378 AI928035 AY335940 BC065189
RefSeq transcript (Entrez)NM_001134222 NM_033267
Consensus coding sequences : CCDS (NCBI)IRX2
Gene ExpressionIRX2 [ NCBI-GEO ]   IRX2 [ EBI - ARRAY_EXPRESS ]   IRX2 [ SEEK ]   IRX2 [ MEM ]
Gene Expression Viewer (FireBrowse)IRX2 [ Firebrowse - Broad ]
GenevisibleExpression of IRX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)153572
GTEX Portal (Tissue expression)IRX2
Human Protein AtlasENSG00000170561-IRX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZI1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZI1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZI1
PhosPhoSitePlusQ9BZI1
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_CS    Homeobox_dom    Homeobox_KN_domain    Iroquois_homeo   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  IRO (SM00548)  
Conserved Domain (NCBI)IRX2
SuperfamilyQ9BZI1
AlphaFold pdb e-kbQ9BZI1   
Human Protein Atlas [tissue]ENSG00000170561-IRX2 [tissue]
HPRD09368
Protein Interaction databases
DIP (DOE-UCLA)Q9BZI1
IntAct (EBI)Q9BZI1
BioGRIDIRX2
STRING (EMBL)IRX2
ZODIACIRX2
Ontologies - Pathways
QuickGOQ9BZI1
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  neuron differentiation  sequence-specific DNA binding  cell development  specification of loop of Henle identity  proximal/distal pattern formation involved in metanephric nephron development  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  neuron differentiation  sequence-specific DNA binding  cell development  specification of loop of Henle identity  proximal/distal pattern formation involved in metanephric nephron development  
NDEx NetworkIRX2
Atlas of Cancer Signalling NetworkIRX2
Wikipedia pathwaysIRX2
Orthology - Evolution
OrthoDB153572
GeneTree (enSembl)ENSG00000170561
Phylogenetic Trees/Animal Genes : TreeFamIRX2
Homologs : HomoloGeneIRX2
Homology/Alignments : Family Browser (UCSC)IRX2
Gene fusions - Rearrangements
Fusion : QuiverIRX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRX2
dbVarIRX2
ClinVarIRX2
MonarchIRX2
1000_GenomesIRX2 
Exome Variant ServerIRX2
GNOMAD BrowserENSG00000170561
Varsome BrowserIRX2
ACMGIRX2 variants
VarityQ9BZI1
Genomic Variants (DGV)IRX2 [DGVbeta]
DECIPHERIRX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRX2 
Mutations
ICGC Data PortalIRX2 
TCGA Data PortalIRX2 
Broad Tumor PortalIRX2
OASIS PortalIRX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIRX2
Mutations and Diseases : HGMDIRX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIRX2
DgiDB (Drug Gene Interaction Database)IRX2
DoCM (Curated mutations)IRX2
CIViC (Clinical Interpretations of Variants in Cancer)IRX2
Cancer3DIRX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606198   
Orphanet23715   
DisGeNETIRX2
MedgenIRX2
Genetic Testing Registry IRX2
NextProtQ9BZI1 [Medical]
GENETestsIRX2
Target ValidationIRX2
Huge Navigator IRX2 [HugePedia]
ClinGenIRX2
Clinical trials, drugs, therapy
MyCancerGenomeIRX2
Protein Interactions : CTDIRX2
Pharm GKB GenePA29925
PharosQ9BZI1
Clinical trialIRX2
Miscellaneous
canSAR (ICR)IRX2
HarmonizomeIRX2
ARCHS4IRX2
DataMed IndexIRX2
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIRX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:38:58 CET 2022

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