IRX3 (iroquois homeobox 3)

2014-08-01 Affiliation

Identity

HGNC

IRX3

LOCATION

16q12.2

LOCUSID

79191

ALIAS

IRX-1,IRXB1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79191
MIM: 612985
HGNC: 14360
Ensembl: ENSG00000177508

Variants:

dbSNP: 79191
ClinVar: 79191
TCGA: ENSG00000177508
COSMIC: IRX3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177508	ENST00000329734	P78415
ENSG00000177508	ENST00000558054	J3QR11

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
24646999	2014	Obesity-associated variants within FTO form long-range functional connections with IRX3.	389
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
20080751	2010	Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.	70
28988979	2017	IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.	16
26440677	2016	Association of FTO and IRX3 genetic variants to obesity risk in north India.	10
27560134	2016	FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?	7
30522931	2019	The partial inhibition of hypothalamic IRX3 exacerbates obesity.	7
25512384	2015	The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells.	4
27241637	2016	Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?	4
30246301	2019	The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.	4

Citation

Dessen P

IRX3 (iroquois homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54385/irx3