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IRX4 (iroquois homeobox 4)

Identity

Alias_namesiroquois homeobox protein 4
Other aliasIRXA3
HGNC (Hugo) IRX4
LocusID (NCBI) 50805
Atlas_Id 52873
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 1877427 and ends at 1887179 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MARCH6 (5p15.2) / IRX4 (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)IRX4   6129
Cards
Entrez_Gene (NCBI)IRX4  50805  iroquois homeobox 4
AliasesIRXA3
GeneCards (Weizmann)IRX4
Ensembl hg19 (Hinxton)ENSG00000113430 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113430 [Gene_View]  chr5:1877427-1887179 [Contig_View]  IRX4 [Vega]
ICGC DataPortalENSG00000113430
TCGA cBioPortalIRX4
AceView (NCBI)IRX4
Genatlas (Paris)IRX4
WikiGenes50805
SOURCE (Princeton)IRX4
Genetics Home Reference (NIH)IRX4
Genomic and cartography
GoldenPath hg38 (UCSC)IRX4  -     chr5:1877427-1887179 -  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRX4  -     5p15.33   [Description]    (hg19-Feb_2009)
EnsemblIRX4 - 5p15.33 [CytoView hg19]  IRX4 - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBIIRX4 [Mapview hg19]  IRX4 [Mapview hg38]
OMIM606199   
Gene and transcription
Genbank (Entrez)AB690778 AB690779 AB690780 AB690781 AF124733
RefSeq transcript (Entrez)NM_001278632 NM_001278633 NM_001278634 NM_001278635 NM_016358
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRX4
Cluster EST : UnigeneHs.196927 [ NCBI ]
CGAP (NCI)Hs.196927
Alternative Splicing GalleryENSG00000113430
Gene ExpressionIRX4 [ NCBI-GEO ]   IRX4 [ EBI - ARRAY_EXPRESS ]   IRX4 [ SEEK ]   IRX4 [ MEM ]
Gene Expression Viewer (FireBrowse)IRX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50805
GTEX Portal (Tissue expression)IRX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78413   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78413  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78413
Splice isoforms : SwissVarP78413
PhosPhoSitePlusP78413
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_KN_domain    Iroquois_homeo   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  IRO (SM00548)  
Conserved Domain (NCBI)IRX4
DMDM Disease mutations50805
Blocks (Seattle)IRX4
SuperfamilyP78413
Human Protein AtlasENSG00000113430
Peptide AtlasP78413
HPRD09369
IPIIPI00019752   IPI00964266   IPI00965036   
Protein Interaction databases
DIP (DOE-UCLA)P78413
IntAct (EBI)P78413
FunCoupENSG00000113430
BioGRIDIRX4
STRING (EMBL)IRX4
ZODIACIRX4
Ontologies - Pathways
QuickGOP78413
Ontology : AmiGOnucleus  regulation of transcription, DNA-templated  heart development  sequence-specific DNA binding  establishment of animal organ orientation  
Ontology : EGO-EBInucleus  regulation of transcription, DNA-templated  heart development  sequence-specific DNA binding  establishment of animal organ orientation  
NDEx NetworkIRX4
Atlas of Cancer Signalling NetworkIRX4
Wikipedia pathwaysIRX4
Orthology - Evolution
OrthoDB50805
GeneTree (enSembl)ENSG00000113430
Phylogenetic Trees/Animal Genes : TreeFamIRX4
HOVERGENP78413
HOGENOMP78413
Homologs : HomoloGeneIRX4
Homology/Alignments : Family Browser (UCSC)IRX4
Gene fusions - Rearrangements
Fusion : MitelmanMARCH6/IRX4 [5p15.2/5p15.33]  [t(5;5)(p15;p15)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRX4
dbVarIRX4
ClinVarIRX4
1000_GenomesIRX4 
Exome Variant ServerIRX4
ExAC (Exome Aggregation Consortium)IRX4 (select the gene name)
Genetic variants : HAPMAP50805
Genomic Variants (DGV)IRX4 [DGVbeta]
DECIPHERIRX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRX4 
Mutations
ICGC Data PortalIRX4 
TCGA Data PortalIRX4 
Broad Tumor PortalIRX4
OASIS PortalIRX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRX4
DgiDB (Drug Gene Interaction Database)IRX4
DoCM (Curated mutations)IRX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRX4 (select a term)
intoGenIRX4
Cancer3DIRX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606199   
Orphanet
MedgenIRX4
Genetic Testing Registry IRX4
NextProtP78413 [Medical]
TSGene50805
GENETestsIRX4
Target ValidationIRX4
Huge Navigator IRX4 [HugePedia]
snp3D : Map Gene to Disease50805
BioCentury BCIQIRX4
ClinGenIRX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50805
Chemical/Pharm GKB GenePA29927
Clinical trialIRX4
Miscellaneous
canSAR (ICR)IRX4 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRX4
EVEXIRX4
GoPubMedIRX4
iHOPIRX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:04:13 CEST 2017

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