IRX5 (iroquois homeobox 5)

2008-09-01 Affiliation

Identity

HGNC

IRX5

LOCATION

16q12.2

LOCUSID

10265

ALIAS

HMMS,IRX-2a,IRXB2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10265
MIM: 606195
HGNC: 14361
Ensembl: ENSG00000176842

Variants:

dbSNP: 10265
ClinVar: 10265
TCGA: ENSG00000176842
COSMIC: IRX5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176842	ENST00000320990	P78411
ENSG00000176842	ENST00000394636	P78411
ENSG00000176842	ENST00000560154	H0YML8
ENSG00000176842	ENST00000620085	A2RRB5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
18519790	2008	The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.	22
22581230	2012	Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.	20
26642925	2015	Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.	8
30246301	2019	The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.	4
31432570	2019	IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway.	1
16527195	2006	[Irx5: a transcription factor that regulates the cardiac repolarization gradient].	0

Citation

Dessen P

IRX5 (iroquois homeobox 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50378/irx5