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IRX5 (iroquois homeobox 5)

Identity

Alias_symbol (synonym)IRX-2a
Other aliasHMMS
IRXB2
HGNC (Hugo) IRX5
LocusID (NCBI) 10265
Atlas_Id 50378
Location 16q12.2  [Link to chromosome band 16q12]
Location_base_pair Starts at 54931199 and ends at 54934483 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRX5   14361
Cards
Entrez_Gene (NCBI)IRX5  10265  iroquois homeobox 5
AliasesHMMS; IRX-2a; IRXB2
GeneCards (Weizmann)IRX5
Ensembl hg19 (Hinxton)ENSG00000176842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176842 [Gene_View]  chr16:54931199-54934483 [Contig_View]  IRX5 [Vega]
ICGC DataPortalENSG00000176842
TCGA cBioPortalIRX5
AceView (NCBI)IRX5
Genatlas (Paris)IRX5
WikiGenes10265
SOURCE (Princeton)IRX5
Genetics Home Reference (NIH)IRX5
Genomic and cartography
GoldenPath hg38 (UCSC)IRX5  -     chr16:54931199-54934483 +  16q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRX5  -     16q12.2   [Description]    (hg19-Feb_2009)
EnsemblIRX5 - 16q12.2 [CytoView hg19]  IRX5 - 16q12.2 [CytoView hg38]
Mapping of homologs : NCBIIRX5 [Mapview hg19]  IRX5 [Mapview hg38]
OMIM606195   611174   
Gene and transcription
Genbank (Entrez)AY335945 BC074850 BC131510 U90304 U90309
RefSeq transcript (Entrez)NM_001252197 NM_005853
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRX5
Cluster EST : UnigeneHs.435730 [ NCBI ]
CGAP (NCI)Hs.435730
Alternative Splicing GalleryENSG00000176842
Gene ExpressionIRX5 [ NCBI-GEO ]   IRX5 [ EBI - ARRAY_EXPRESS ]   IRX5 [ SEEK ]   IRX5 [ MEM ]
Gene Expression Viewer (FireBrowse)IRX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10265
GTEX Portal (Tissue expression)IRX5
Human Protein AtlasENSG00000176842-IRX5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78411   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78411  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78411
Splice isoforms : SwissVarP78411
PhosPhoSitePlusP78411
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    Homeobox_KN_domain    Iroquois_homeo   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  IRO (SM00548)  
Conserved Domain (NCBI)IRX5
DMDM Disease mutations10265
Blocks (Seattle)IRX5
SuperfamilyP78411
Human Protein Atlas [tissue]ENSG00000176842-IRX5 [tissue]
Peptide AtlasP78411
HPRD08395
IPIIPI00456865   IPI00829706   IPI00843908   
Protein Interaction databases
DIP (DOE-UCLA)P78411
IntAct (EBI)P78411
FunCoupENSG00000176842
BioGRIDIRX5
STRING (EMBL)IRX5
ZODIACIRX5
Ontologies - Pathways
QuickGOP78411
Ontology : AmiGOregulation of heart rate  vitamin D binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  visual perception  gonad development  neuron maturation  sequence-specific DNA binding  embryonic cranial skeleton morphogenesis  response to stimulus  retinal bipolar neuron differentiation  
Ontology : EGO-EBIregulation of heart rate  vitamin D binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  visual perception  gonad development  neuron maturation  sequence-specific DNA binding  embryonic cranial skeleton morphogenesis  response to stimulus  retinal bipolar neuron differentiation  
NDEx NetworkIRX5
Atlas of Cancer Signalling NetworkIRX5
Wikipedia pathwaysIRX5
Orthology - Evolution
OrthoDB10265
GeneTree (enSembl)ENSG00000176842
Phylogenetic Trees/Animal Genes : TreeFamIRX5
HOVERGENP78411
HOGENOMP78411
Homologs : HomoloGeneIRX5
Homology/Alignments : Family Browser (UCSC)IRX5
Gene fusions - Rearrangements
Tumor Fusion PortalIRX5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRX5
dbVarIRX5
ClinVarIRX5
1000_GenomesIRX5 
Exome Variant ServerIRX5
ExAC (Exome Aggregation Consortium)ENSG00000176842
GNOMAD BrowserENSG00000176842
Genetic variants : HAPMAP10265
Genomic Variants (DGV)IRX5 [DGVbeta]
DECIPHERIRX5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRX5 
Mutations
ICGC Data PortalIRX5 
TCGA Data PortalIRX5 
Broad Tumor PortalIRX5
OASIS PortalIRX5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRX5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch IRX5
DgiDB (Drug Gene Interaction Database)IRX5
DoCM (Curated mutations)IRX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRX5 (select a term)
intoGenIRX5
Cancer3DIRX5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606195    611174   
Orphanet21494   
DisGeNETIRX5
MedgenIRX5
Genetic Testing Registry IRX5
NextProtP78411 [Medical]
TSGene10265
GENETestsIRX5
Target ValidationIRX5
Huge Navigator IRX5 [HugePedia]
snp3D : Map Gene to Disease10265
BioCentury BCIQIRX5
ClinGenIRX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10265
Chemical/Pharm GKB GenePA29928
Clinical trialIRX5
Miscellaneous
canSAR (ICR)IRX5 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRX5
EVEXIRX5
GoPubMedIRX5
iHOPIRX5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:18:08 CET 2017

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