Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ISCU (iron-sulfur cluster assembly enzyme)

Identity

Alias_namesNIFUN
NifU-like N-terminal domain containing
IscU iron-sulfur cluster scaffold homolog (E. coli)
iron-sulfur cluster scaffold homolog (E. coli)
Alias_symbol (synonym)ISU2
hnifU
IscU
Other alias2310020H20Rik
HML
NIFU
HGNC (Hugo) ISCU
LocusID (NCBI) 23479
Atlas_Id 53990
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 108561463 and ends at 108569384 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTSZ (20q13.32) / ISCU (12q23.3)ISCU (12q23.3) / CLASP2 (3p22.3)ISCU (12q23.3) / ISCU (12q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ISCU   29882
Cards
Entrez_Gene (NCBI)ISCU  23479  iron-sulfur cluster assembly enzyme
Aliases2310020H20Rik; HML; ISU2; NIFU; 
NIFUN; hnifU
GeneCards (Weizmann)ISCU
Ensembl hg19 (Hinxton)ENSG00000136003 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136003 [Gene_View]  chr12:108561463-108569384 [Contig_View]  ISCU [Vega]
ICGC DataPortalENSG00000136003
TCGA cBioPortalISCU
AceView (NCBI)ISCU
Genatlas (Paris)ISCU
WikiGenes23479
SOURCE (Princeton)ISCU
Genetics Home Reference (NIH)ISCU
Genomic and cartography
GoldenPath hg38 (UCSC)ISCU  -     chr12:108561463-108569384 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ISCU  -     12q23.3   [Description]    (hg19-Feb_2009)
EnsemblISCU - 12q23.3 [CytoView hg19]  ISCU - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBIISCU [Mapview hg19]  ISCU [Mapview hg38]
OMIM255125   611911   
Gene and transcription
Genbank (Entrez)AK000574 AK022758 AK057251 AK293202 AK297862
RefSeq transcript (Entrez)NM_001301140 NM_001301141 NM_001320042 NM_014301 NM_213595
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ISCU
Cluster EST : UnigeneHs.615131 [ NCBI ]
CGAP (NCI)Hs.615131
Alternative Splicing GalleryENSG00000136003
Gene ExpressionISCU [ NCBI-GEO ]   ISCU [ EBI - ARRAY_EXPRESS ]   ISCU [ SEEK ]   ISCU [ MEM ]
Gene Expression Viewer (FireBrowse)ISCU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23479
GTEX Portal (Tissue expression)ISCU
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1K1
Splice isoforms : SwissVarQ9H1K1
PhosPhoSitePlusQ9H1K1
Domains : Interpro (EBI)ISC_FeS_clus_asmbl_IscU    NIF_FeS_clus_asmbl_NifU_N   
Domain families : Pfam (Sanger)NifU_N (PF01592)   
Domain families : Pfam (NCBI)pfam01592   
Conserved Domain (NCBI)ISCU
DMDM Disease mutations23479
Blocks (Seattle)ISCU
PDB (SRS)5KZ5   
PDB (PDBSum)5KZ5   
PDB (IMB)5KZ5   
PDB (RSDB)5KZ5   
Structural Biology KnowledgeBase5KZ5   
SCOP (Structural Classification of Proteins)5KZ5   
CATH (Classification of proteins structures)5KZ5   
SuperfamilyQ9H1K1
Human Protein AtlasENSG00000136003
Peptide AtlasQ9H1K1
HPRD14828
IPIIPI00022240   IPI00164885   IPI00890793   IPI00909212   IPI00848133   IPI01009402   IPI00793728   
Protein Interaction databases
DIP (DOE-UCLA)Q9H1K1
IntAct (EBI)Q9H1K1
FunCoupENSG00000136003
BioGRIDISCU
STRING (EMBL)ISCU
ZODIACISCU
Ontologies - Pathways
QuickGOQ9H1K1
Ontology : AmiGOiron ion binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cellular iron ion homeostasis  ferrous iron binding  nitrogen fixation  iron-sulfur cluster assembly  protein complex scaffold  iron-sulfur transferase activity  small molecule metabolic process  2 iron, 2 sulfur cluster binding  4 iron, 4 sulfur cluster binding  protein maturation by iron-sulfur cluster transfer  
Ontology : EGO-EBIiron ion binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cellular iron ion homeostasis  ferrous iron binding  nitrogen fixation  iron-sulfur cluster assembly  protein complex scaffold  iron-sulfur transferase activity  small molecule metabolic process  2 iron, 2 sulfur cluster binding  4 iron, 4 sulfur cluster binding  protein maturation by iron-sulfur cluster transfer  
NDEx NetworkISCU
Atlas of Cancer Signalling NetworkISCU
Wikipedia pathwaysISCU
Orthology - Evolution
OrthoDB23479
GeneTree (enSembl)ENSG00000136003
Phylogenetic Trees/Animal Genes : TreeFamISCU
HOVERGENQ9H1K1
HOGENOMQ9H1K1
Homologs : HomoloGeneISCU
Homology/Alignments : Family Browser (UCSC)ISCU
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerISCU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ISCU
dbVarISCU
ClinVarISCU
1000_GenomesISCU 
Exome Variant ServerISCU
ExAC (Exome Aggregation Consortium)ISCU (select the gene name)
Genetic variants : HAPMAP23479
Genomic Variants (DGV)ISCU [DGVbeta]
DECIPHERISCU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisISCU 
Mutations
ICGC Data PortalISCU 
TCGA Data PortalISCU 
Broad Tumor PortalISCU
OASIS PortalISCU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICISCU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDISCU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ISCU
DgiDB (Drug Gene Interaction Database)ISCU
DoCM (Curated mutations)ISCU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ISCU (select a term)
intoGenISCU
Cancer3DISCU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM255125    611911   
Orphanet10579   
MedgenISCU
Genetic Testing Registry ISCU
NextProtQ9H1K1 [Medical]
TSGene23479
GENETestsISCU
Huge Navigator ISCU [HugePedia]
snp3D : Map Gene to Disease23479
BioCentury BCIQISCU
ClinGenISCU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23479
Chemical/Pharm GKB GenePA162392328
Clinical trialISCU
Miscellaneous
canSAR (ICR)ISCU (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineISCU
EVEXISCU
GoPubMedISCU
iHOPISCU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:20:47 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.