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ISG15 (ISG15 ubiquitin-like modifier)

Identity

Alias_namesG1P2
interferon
Alias_symbol (synonym)IFI15
UCRP
Other aliasIMD38
IP17
hUCRP
HGNC (Hugo) ISG15
LocusID (NCBI) 9636
Atlas_Id 40661
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1013467 and ends at 1014539 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ISG15   4053
Cards
Entrez_Gene (NCBI)ISG15  9636  ISG15 ubiquitin-like modifier
AliasesG1P2; IFI15; IMD38; IP17; 
UCRP; hUCRP
GeneCards (Weizmann)ISG15
Ensembl hg19 (Hinxton)ENSG00000187608 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187608 [Gene_View]  ENSG00000187608 [Sequence]  chr1:1013467-1014539 [Contig_View]  ISG15 [Vega]
ICGC DataPortalENSG00000187608
TCGA cBioPortalISG15
AceView (NCBI)ISG15
Genatlas (Paris)ISG15
WikiGenes9636
SOURCE (Princeton)ISG15
Genetics Home Reference (NIH)ISG15
Genomic and cartography
GoldenPath hg38 (UCSC)ISG15  -     chr1:1013467-1014539 +  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ISG15  -     1p36.33   [Description]    (hg19-Feb_2009)
EnsemblISG15 - 1p36.33 [CytoView hg19]  ISG15 - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBIISG15 [Mapview hg19]  ISG15 [Mapview hg38]
OMIM147571   616126   
Gene and transcription
Genbank (Entrez)AY168648 BC009507 BM712238 BT007297 BU161226
RefSeq transcript (Entrez)NM_005101
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ISG15
Cluster EST : UnigeneHs.458485 [ NCBI ]
CGAP (NCI)Hs.458485
Alternative Splicing GalleryENSG00000187608
Gene ExpressionISG15 [ NCBI-GEO ]   ISG15 [ EBI - ARRAY_EXPRESS ]   ISG15 [ SEEK ]   ISG15 [ MEM ]
Gene Expression Viewer (FireBrowse)ISG15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9636
GTEX Portal (Tissue expression)ISG15
Human Protein AtlasENSG00000187608-ISG15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05161
Splice isoforms : SwissVarP05161
PhosPhoSitePlusP05161
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ubiquitin    Ubiquitin-like_domsf    Ubiquitin_dom   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)ISG15
DMDM Disease mutations9636
Blocks (Seattle)ISG15
PDB (SRS)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
PDB (PDBSum)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
PDB (IMB)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
PDB (RSDB)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
Structural Biology KnowledgeBase1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
SCOP (Structural Classification of Proteins)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
CATH (Classification of proteins structures)1Z2M    2HJ8    3PHX    3PSE    3R66    3RT3    3SDL    5TL6    5W8T    5W8U    6FFA   
SuperfamilyP05161
Human Protein Atlas [tissue]ENSG00000187608-ISG15 [tissue]
Peptide AtlasP05161
HPRD00958
IPIIPI00375631   
Protein Interaction databases
DIP (DOE-UCLA)P05161
IntAct (EBI)P05161
FunCoupENSG00000187608
BioGRIDISG15
STRING (EMBL)ISG15
ZODIACISG15
Ontologies - Pathways
QuickGOP05161
Ontology : AmiGOprotein binding  extracellular region  nucleoplasm  cytosol  viral process  modification-dependent protein catabolic process  translesion synthesis  positive regulation of bone mineralization  protein tag  negative regulation of protein ubiquitination  ISG15-protein conjugation  ISG15-protein conjugation  negative regulation of type I interferon production  regulation of interferon-gamma production  response to type I interferon  defense response to bacterium  negative regulation of viral genome replication  positive regulation of erythrocyte differentiation  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBIprotein binding  extracellular region  nucleoplasm  cytosol  viral process  modification-dependent protein catabolic process  translesion synthesis  positive regulation of bone mineralization  protein tag  negative regulation of protein ubiquitination  ISG15-protein conjugation  ISG15-protein conjugation  negative regulation of type I interferon production  regulation of interferon-gamma production  response to type I interferon  defense response to bacterium  negative regulation of viral genome replication  positive regulation of erythrocyte differentiation  defense response to virus  type I interferon signaling pathway  
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkISG15
Atlas of Cancer Signalling NetworkISG15
Wikipedia pathwaysISG15
Orthology - Evolution
OrthoDB9636
GeneTree (enSembl)ENSG00000187608
Phylogenetic Trees/Animal Genes : TreeFamISG15
HOVERGENP05161
HOGENOMP05161
Homologs : HomoloGeneISG15
Homology/Alignments : Family Browser (UCSC)ISG15
Gene fusions - Rearrangements
Fusion : QuiverISG15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerISG15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ISG15
dbVarISG15
ClinVarISG15
1000_GenomesISG15 
Exome Variant ServerISG15
ExAC (Exome Aggregation Consortium)ENSG00000187608
GNOMAD BrowserENSG00000187608
Varsome BrowserISG15
Genetic variants : HAPMAP9636
Genomic Variants (DGV)ISG15 [DGVbeta]
DECIPHERISG15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisISG15 
Mutations
ICGC Data PortalISG15 
TCGA Data PortalISG15 
Broad Tumor PortalISG15
OASIS PortalISG15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICISG15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDISG15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch ISG15
DgiDB (Drug Gene Interaction Database)ISG15
DoCM (Curated mutations)ISG15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ISG15 (select a term)
intoGenISG15
Cancer3DISG15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147571    616126   
Orphanet21674   
DisGeNETISG15
MedgenISG15
Genetic Testing Registry ISG15
NextProtP05161 [Medical]
TSGene9636
GENETestsISG15
Target ValidationISG15
Huge Navigator ISG15 [HugePedia]
snp3D : Map Gene to Disease9636
BioCentury BCIQISG15
ClinGenISG15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9636
Chemical/Pharm GKB GenePA28465
Clinical trialISG15
Miscellaneous
canSAR (ICR)ISG15 (select the gene name)
Probes
Litterature
PubMed173 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineISG15
EVEXISG15
GoPubMedISG15
iHOPISG15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:13:55 CET 2018
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