ISG15 (ISG15 ubiquitin like modifier)

2003-05-01 Affiliation

Identity

HGNC

ISG15

LOCATION

1p36.33

LOCUSID

9636

ALIAS

G1P2,IFI15,IMD38,IP17,UCRP,hUCRP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9636
MIM: 147571
HGNC: 4053
Ensembl: ENSG00000187608

Variants:

dbSNP: 9636
ClinVar: 9636
TCGA: ENSG00000187608
COSMIC: ISG15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187608	ENST00000624652	A0A096LNZ9
ENSG00000187608	ENST00000624697	A0A096LPJ4
ENSG00000187608	ENST00000649529	P05161

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Host Interactions with Influenza Factors	REACTOME	R-HSA-168253
NS1 Mediated Effects on Host Pathways	REACTOME	R-HSA-168276
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
DNA Repair	REACTOME	R-HSA-73894
DNA Damage Bypass	REACTOME	R-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Termination of translesion DNA synthesis	REACTOME	R-HSA-5656169

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16009940	2005	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	177
22859821	2012	Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.	161
16434471	2006	Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.	155
25307056	2015	Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.	131
18305167	2008	ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.	120
20542004	2010	The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.	120
20308324	2010	Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.	96
20946978	2010	Emerging role of ISG15 in antiviral immunity.	95
20133869	2010	ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.	93
16139798	2005	Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.	86

Citation

Dessen P

ISG15 (ISG15 ubiquitin like modifier)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40661/isg15