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ISG20 (interferon stimulated exonuclease gene 20)

Identity

Alias_namesinterferon stimulated exonuclease gene 20kDa
Alias_symbol (synonym)HEM45
CD25
Other alias
HGNC (Hugo) ISG20
LocusID (NCBI) 3669
Atlas_Id 40997
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 88635637 and ends at 88656344 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ISG20 (15q26.1) / TBCC (6p21.1)ZNHIT6 (1p22.3) / ISG20 (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ISG20   6130
Cards
Entrez_Gene (NCBI)ISG20  3669  interferon stimulated exonuclease gene 20
AliasesCD25; HEM45
GeneCards (Weizmann)ISG20
Ensembl hg19 (Hinxton)ENSG00000172183 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172183 [Gene_View]  chr15:88635637-88656344 [Contig_View]  ISG20 [Vega]
ICGC DataPortalENSG00000172183
TCGA cBioPortalISG20
AceView (NCBI)ISG20
Genatlas (Paris)ISG20
WikiGenes3669
SOURCE (Princeton)ISG20
Genetics Home Reference (NIH)ISG20
Genomic and cartography
GoldenPath hg38 (UCSC)ISG20  -     chr15:88635637-88656344 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ISG20  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblISG20 - 15q26.1 [CytoView hg19]  ISG20 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIISG20 [Mapview hg19]  ISG20 [Mapview hg38]
OMIM604533   
Gene and transcription
Genbank (Entrez)AB209639 AK122793 AK307769 AV737297 BC007922
RefSeq transcript (Entrez)NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237 NM_002201
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ISG20
Cluster EST : UnigeneHs.459265 [ NCBI ]
CGAP (NCI)Hs.459265
Alternative Splicing GalleryENSG00000172183
Gene ExpressionISG20 [ NCBI-GEO ]   ISG20 [ EBI - ARRAY_EXPRESS ]   ISG20 [ SEEK ]   ISG20 [ MEM ]
Gene Expression Viewer (FireBrowse)ISG20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3669
GTEX Portal (Tissue expression)ISG20
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AZ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AZ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AZ6
Splice isoforms : SwissVarQ96AZ6
Catalytic activity : Enzyme3.1.13.1 [ Enzyme-Expasy ]   3.1.13.13.1.13.1 [ IntEnz-EBI ]   3.1.13.1 [ BRENDA ]   3.1.13.1 [ KEGG ]   
PhosPhoSitePlusQ96AZ6
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    RNaseH-like_dom   
Domain families : Pfam (Sanger)RNase_T (PF00929)   
Domain families : Pfam (NCBI)pfam00929   
Domain families : Smart (EMBL)EXOIII (SM00479)  
Conserved Domain (NCBI)ISG20
DMDM Disease mutations3669
Blocks (Seattle)ISG20
PDB (SRS)1WLJ   
PDB (PDBSum)1WLJ   
PDB (IMB)1WLJ   
PDB (RSDB)1WLJ   
Structural Biology KnowledgeBase1WLJ   
SCOP (Structural Classification of Proteins)1WLJ   
CATH (Classification of proteins structures)1WLJ   
SuperfamilyQ96AZ6
Human Protein AtlasENSG00000172183
Peptide AtlasQ96AZ6
HPRD05169
IPIIPI00647246   IPI00514614   IPI00031824   
Protein Interaction databases
DIP (DOE-UCLA)Q96AZ6
IntAct (EBI)Q96AZ6
FunCoupENSG00000172183
BioGRIDISG20
STRING (EMBL)ISG20
ZODIACISG20
Ontologies - Pathways
QuickGOQ96AZ6
Ontology : AmiGO3'-5'-exoribonuclease activity  DNA catabolic process, exonucleolytic  exonuclease activity  nucleus  nucleoplasm  nucleolus  cytoplasm  rRNA processing  RNA catabolic process  cell proliferation  single-stranded DNA 3'-5' exodeoxyribonuclease activity  exoribonuclease II activity  response to virus  Cajal body  PML body  U1 snRNA binding  U2 snRNA binding  U3 snoRNA binding  negative regulation of viral genome replication  metal ion binding  defense response to virus  type I interferon signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  DNA catabolic process, exonucleolytic  exonuclease activity  nucleus  nucleoplasm  nucleolus  cytoplasm  rRNA processing  RNA catabolic process  cell proliferation  single-stranded DNA 3'-5' exodeoxyribonuclease activity  exoribonuclease II activity  response to virus  Cajal body  PML body  U1 snRNA binding  U2 snRNA binding  U3 snoRNA binding  negative regulation of viral genome replication  metal ion binding  defense response to virus  type I interferon signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  
NDEx NetworkISG20
Atlas of Cancer Signalling NetworkISG20
Wikipedia pathwaysISG20
Orthology - Evolution
OrthoDB3669
GeneTree (enSembl)ENSG00000172183
Phylogenetic Trees/Animal Genes : TreeFamISG20
HOVERGENQ96AZ6
HOGENOMQ96AZ6
Homologs : HomoloGeneISG20
Homology/Alignments : Family Browser (UCSC)ISG20
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerISG20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ISG20
dbVarISG20
ClinVarISG20
1000_GenomesISG20 
Exome Variant ServerISG20
ExAC (Exome Aggregation Consortium)ISG20 (select the gene name)
Genetic variants : HAPMAP3669
Genomic Variants (DGV)ISG20 [DGVbeta]
DECIPHERISG20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisISG20 
Mutations
ICGC Data PortalISG20 
TCGA Data PortalISG20 
Broad Tumor PortalISG20
OASIS PortalISG20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICISG20  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDISG20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ISG20
DgiDB (Drug Gene Interaction Database)ISG20
DoCM (Curated mutations)ISG20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ISG20 (select a term)
intoGenISG20
Cancer3DISG20(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604533   
Orphanet
MedgenISG20
Genetic Testing Registry ISG20
NextProtQ96AZ6 [Medical]
TSGene3669
GENETestsISG20
Target ValidationISG20
Huge Navigator ISG20 [HugePedia]
snp3D : Map Gene to Disease3669
BioCentury BCIQISG20
ClinGenISG20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3669
Chemical/Pharm GKB GenePA29930
Clinical trialISG20
Miscellaneous
canSAR (ICR)ISG20 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineISG20
EVEXISG20
GoPubMedISG20
iHOPISG20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:13:40 CEST 2017

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