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ISL2 (ISL LIM homeobox 2)

Identity

Alias_namesISL2 transcription factor, LIM/homeodomain, (islet-2)
Alias_symbol (synonym)FLJ10160
Other alias-
HGNC (Hugo) ISL2
LocusID (NCBI) 64843
Atlas_Id 64670
Location 15q24.3  [Link to chromosome band 15q24]
Location_base_pair Starts at 76629065 and ends at 76634816 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ISL2   18524
Cards
Entrez_Gene (NCBI)ISL2  64843  ISL LIM homeobox 2
Aliases
GeneCards (Weizmann)ISL2
Ensembl hg19 (Hinxton)ENSG00000159556 [Gene_View]  chr15:76629065-76634816 [Contig_View]  ISL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000159556 [Gene_View]  chr15:76629065-76634816 [Contig_View]  ISL2 [Vega]
ICGC DataPortalENSG00000159556
TCGA cBioPortalISL2
AceView (NCBI)ISL2
Genatlas (Paris)ISL2
WikiGenes64843
SOURCE (Princeton)ISL2
Genetics Home Reference (NIH)ISL2
Genomic and cartography
GoldenPath hg19 (UCSC)ISL2  -     chr15:76629065-76634816 +  15q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ISL2  -     15q24.3   [Description]    (hg38-Dec_2013)
EnsemblISL2 - 15q24.3 [CytoView hg19]  ISL2 - 15q24.3 [CytoView hg38]
Mapping of homologs : NCBIISL2 [Mapview hg19]  ISL2 [Mapview hg38]
OMIM609481   
Gene and transcription
Genbank (Entrez)AB593133 AK001022 BC011967 BC012136 DB055557
RefSeq transcript (Entrez)NM_145805
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)ISL2
Cluster EST : UnigeneHs.444677 [ NCBI ]
CGAP (NCI)Hs.444677
Alternative Splicing GalleryENSG00000159556
Gene ExpressionISL2 [ NCBI-GEO ]   ISL2 [ EBI - ARRAY_EXPRESS ]   ISL2 [ SEEK ]   ISL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ISL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64843
GTEX Portal (Tissue expression)ISL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96A47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96A47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96A47
Splice isoforms : SwissVarQ96A47
PhosPhoSitePlusQ96A47
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    Znf_LIM   
Domain families : Pfam (Sanger)Homeobox (PF00046)    LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00046    pfam00412   
Domain families : Smart (EMBL)HOX (SM00389)  LIM (SM00132)  
Conserved Domain (NCBI)ISL2
DMDM Disease mutations64843
Blocks (Seattle)ISL2
SuperfamilyQ96A47
Human Protein AtlasENSG00000159556
Peptide AtlasQ96A47
HPRD11053
IPIIPI00059240   
Protein Interaction databases
DIP (DOE-UCLA)Q96A47
IntAct (EBI)Q96A47
FunCoupENSG00000159556
BioGRIDISL2
STRING (EMBL)ISL2
ZODIACISL2
Ontologies - Pathways
QuickGOQ96A47
Ontology : AmiGODNA binding  nucleus  regulation of transcription, DNA-templated  zinc ion binding  spinal cord motor neuron cell fate specification  visceral motor neuron differentiation  retinal ganglion cell axon guidance  sequence-specific DNA binding  negative regulation of neuron differentiation  neuron development  peripheral nervous system neuron development  
Ontology : EGO-EBIDNA binding  nucleus  regulation of transcription, DNA-templated  zinc ion binding  spinal cord motor neuron cell fate specification  visceral motor neuron differentiation  retinal ganglion cell axon guidance  sequence-specific DNA binding  negative regulation of neuron differentiation  neuron development  peripheral nervous system neuron development  
NDEx NetworkISL2
Atlas of Cancer Signalling NetworkISL2
Wikipedia pathwaysISL2
Orthology - Evolution
OrthoDB64843
GeneTree (enSembl)ENSG00000159556
Phylogenetic Trees/Animal Genes : TreeFamISL2
HOVERGENQ96A47
HOGENOMQ96A47
Homologs : HomoloGeneISL2
Homology/Alignments : Family Browser (UCSC)ISL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerISL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ISL2
dbVarISL2
ClinVarISL2
1000_GenomesISL2 
Exome Variant ServerISL2
ExAC (Exome Aggregation Consortium)ISL2 (select the gene name)
Genetic variants : HAPMAP64843
Genomic Variants (DGV)ISL2 [DGVbeta]
DECIPHER (Syndromes)15:76629065-76634816  ENSG00000159556
CONAN: Copy Number AnalysisISL2 
Mutations
ICGC Data PortalISL2 
TCGA Data PortalISL2 
Broad Tumor PortalISL2
OASIS PortalISL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICISL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDISL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ISL2
DgiDB (Drug Gene Interaction Database)ISL2
DoCM (Curated mutations)ISL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ISL2 (select a term)
intoGenISL2
Cancer3DISL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609481   
Orphanet
MedgenISL2
Genetic Testing Registry ISL2
NextProtQ96A47 [Medical]
TSGene64843
GENETestsISL2
Huge Navigator ISL2 [HugePedia]
snp3D : Map Gene to Disease64843
BioCentury BCIQISL2
ClinGenISL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64843
Chemical/Pharm GKB GenePA38566
Clinical trialISL2
Miscellaneous
canSAR (ICR)ISL2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineISL2
EVEXISL2
GoPubMedISL2
iHOPISL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:09:02 CET 2017

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