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IST1 (IST1, ESCRT-III associated factor)

Identity

Alias_namesendosomal sorting complex required for transport-III component
KIAA0174
Other aliasOLC1
HGNC (Hugo) IST1
LocusID (NCBI) 9798
Atlas_Id 52362
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 71895493 and ends at 71930637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
INPP4B (4q31.21) / IST1 (16q22.2)IST1 (16q22.2) / ACAP2 (3q29)IST1 (16q22.2) / MYOF (10q23.33)
IST1 (16q22.2) / NXF1 (11q12.3)IST1 (16q22.2) / PRCP (11q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IST1   28977
Cards
Entrez_Gene (NCBI)IST1  9798  IST1, ESCRT-III associated factor
AliasesOLC1
GeneCards (Weizmann)IST1
Ensembl hg19 (Hinxton)ENSG00000182149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182149 [Gene_View]  chr16:71895493-71930637 [Contig_View]  IST1 [Vega]
ICGC DataPortalENSG00000182149
TCGA cBioPortalIST1
AceView (NCBI)IST1
Genatlas (Paris)IST1
WikiGenes9798
SOURCE (Princeton)IST1
Genetics Home Reference (NIH)IST1
Genomic and cartography
GoldenPath hg38 (UCSC)IST1  -     chr16:71895493-71930637 +  16q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IST1  -     16q22.2   [Description]    (hg19-Feb_2009)
EnsemblIST1 - 16q22.2 [CytoView hg19]  IST1 - 16q22.2 [CytoView hg38]
Mapping of homologs : NCBIIST1 [Mapview hg19]  IST1 [Mapview hg38]
OMIM616434   
Gene and transcription
Genbank (Entrez)AB097052 AK057902 AK291388 AK293022 AK293040
RefSeq transcript (Entrez)NM_001270975 NM_001270976 NM_001270977 NM_001270978 NM_001270979 NM_014761
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IST1
Cluster EST : UnigeneHs.232194 [ NCBI ]
CGAP (NCI)Hs.232194
Alternative Splicing GalleryENSG00000182149
Gene ExpressionIST1 [ NCBI-GEO ]   IST1 [ EBI - ARRAY_EXPRESS ]   IST1 [ SEEK ]   IST1 [ MEM ]
Gene Expression Viewer (FireBrowse)IST1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9798
GTEX Portal (Tissue expression)IST1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53990   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53990  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53990
Splice isoforms : SwissVarP53990
PhosPhoSitePlusP53990
Domains : Interpro (EBI)Ist1   
Domain families : Pfam (Sanger)Ist1 (PF03398)   
Domain families : Pfam (NCBI)pfam03398   
Conserved Domain (NCBI)IST1
DMDM Disease mutations9798
Blocks (Seattle)IST1
PDB (SRS)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
PDB (PDBSum)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
PDB (IMB)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
PDB (RSDB)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
Structural Biology KnowledgeBase3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
SCOP (Structural Classification of Proteins)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
CATH (Classification of proteins structures)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX   
SuperfamilyP53990
Human Protein AtlasENSG00000182149
Peptide AtlasP53990
HPRD13784
IPIIPI00024660   IPI00420088   IPI00643007   IPI00939709   IPI00386516   IPI00909013   IPI01010958   IPI00908693   IPI01015451   IPI01015789   IPI01010527   IPI01009134   IPI01012640   
Protein Interaction databases
DIP (DOE-UCLA)P53990
IntAct (EBI)P53990
FunCoupENSG00000182149
BioGRIDIST1
STRING (EMBL)IST1
ZODIACIST1
Ontologies - Pathways
QuickGOP53990
Ontology : AmiGOcytokinesis  protein binding  extracellular region  nuclear envelope  endoplasmic reticulum-Golgi intermediate compartment  centrosome  cytosol  protein localization  abscission  abscission  protein transport  viral release from host cell  protein domain specific binding  midbody  protein complex binding  azurophil granule lumen  multivesicular body assembly  intracellular membrane-bounded organelle  neutrophil degranulation  establishment of protein localization  cadherin binding  positive regulation of proteolysis  viral capsid secondary envelopment  positive regulation of collateral sprouting  cell division  extracellular exosome  MIT domain binding  Flemming body  ESCRT III complex disassembly  
Ontology : EGO-EBIcytokinesis  protein binding  extracellular region  nuclear envelope  endoplasmic reticulum-Golgi intermediate compartment  centrosome  cytosol  protein localization  abscission  abscission  protein transport  viral release from host cell  protein domain specific binding  midbody  protein complex binding  azurophil granule lumen  multivesicular body assembly  intracellular membrane-bounded organelle  neutrophil degranulation  establishment of protein localization  cadherin binding  positive regulation of proteolysis  viral capsid secondary envelopment  positive regulation of collateral sprouting  cell division  extracellular exosome  MIT domain binding  Flemming body  ESCRT III complex disassembly  
NDEx NetworkIST1
Atlas of Cancer Signalling NetworkIST1
Wikipedia pathwaysIST1
Orthology - Evolution
OrthoDB9798
GeneTree (enSembl)ENSG00000182149
Phylogenetic Trees/Animal Genes : TreeFamIST1
HOVERGENP53990
HOGENOMP53990
Homologs : HomoloGeneIST1
Homology/Alignments : Family Browser (UCSC)IST1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IST1
dbVarIST1
ClinVarIST1
1000_GenomesIST1 
Exome Variant ServerIST1
ExAC (Exome Aggregation Consortium)IST1 (select the gene name)
Genetic variants : HAPMAP9798
Genomic Variants (DGV)IST1 [DGVbeta]
DECIPHERIST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIST1 
Mutations
ICGC Data PortalIST1 
TCGA Data PortalIST1 
Broad Tumor PortalIST1
OASIS PortalIST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIST1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIST1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IST1
DgiDB (Drug Gene Interaction Database)IST1
DoCM (Curated mutations)IST1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IST1 (select a term)
intoGenIST1
Cancer3DIST1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616434   
Orphanet
MedgenIST1
Genetic Testing Registry IST1
NextProtP53990 [Medical]
TSGene9798
GENETestsIST1
Target ValidationIST1
Huge Navigator IST1 [HugePedia]
snp3D : Map Gene to Disease9798
BioCentury BCIQIST1
ClinGenIST1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9798
Chemical/Pharm GKB GenePA142671633
Clinical trialIST1
Miscellaneous
canSAR (ICR)IST1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIST1
EVEXIST1
GoPubMedIST1
iHOPIST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:04:14 CEST 2017

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