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IST1 (IST1 factor associated with ESCRT-III)

Identity

Alias (NCBI)CHMP8
OLC1
HGNC (Hugo) IST1
HGNC Alias symbCHMP8
HGNC Alias nameIST1, endosomal sorting complex required for transport-III component
HGNC Previous nameKIAA0174
HGNC Previous nameKIAA0174
 increased sodium tolerance 1 homolog (yeast)
 IST1, ESCRT-III associated factor
LocusID (NCBI) 9798
Atlas_Id 52362
Location 16q22.2  [Link to chromosome band 16q22]
Location_base_pair Starts at 71895531 and ends at 71931196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
INPP4B (4q31.21) / IST1 (16q22.2)IST1 (16q22.2) / ACAP2 (3q29)IST1 (16q22.2) / MYOF (10q23.33)
IST1 (16q22.2) / NXF1 (11q12.3)IST1 (16q22.2) / PRCP (11q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IST1   28977
Cards
Entrez_Gene (NCBI)IST1    IST1 factor associated with ESCRT-III
AliasesCHMP8; OLC1
GeneCards (Weizmann)IST1
Ensembl hg19 (Hinxton)ENSG00000182149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182149 [Gene_View]  ENSG00000182149 [Sequence]  chr16:71895531-71931196 [Contig_View]  IST1 [Vega]
ICGC DataPortalENSG00000182149
TCGA cBioPortalIST1
AceView (NCBI)IST1
Genatlas (Paris)IST1
SOURCE (Princeton)IST1
Genetics Home Reference (NIH)IST1
Genomic and cartography
GoldenPath hg38 (UCSC)IST1  -     chr16:71895531-71931196 +  16q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IST1  -     16q22.2   [Description]    (hg19-Feb_2009)
GoldenPathIST1 - 16q22.2 [CytoView hg19]  IST1 - 16q22.2 [CytoView hg38]
ImmunoBaseENSG00000182149
Genome Data Viewer NCBIIST1 [Mapview hg19]  
OMIM616434   
Gene and transcription
Genbank (Entrez)AB097052 AK057902 AK291388 AK293022 AK293040
RefSeq transcript (Entrez)NM_001270975 NM_001270976 NM_001270977 NM_001270978 NM_001270979 NM_014761
Consensus coding sequences : CCDS (NCBI)IST1
Gene ExpressionIST1 [ NCBI-GEO ]   IST1 [ EBI - ARRAY_EXPRESS ]   IST1 [ SEEK ]   IST1 [ MEM ]
Gene Expression Viewer (FireBrowse)IST1 [ Firebrowse - Broad ]
GenevisibleExpression of IST1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9798
GTEX Portal (Tissue expression)IST1
Human Protein AtlasENSG00000182149-IST1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53990   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53990  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53990
PhosPhoSitePlusP53990
Domains : Interpro (EBI)Ist1    IST1-like   
Domain families : Pfam (Sanger)Ist1 (PF03398)   
Domain families : Pfam (NCBI)pfam03398   
Conserved Domain (NCBI)IST1
PDB (RSDB)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
PDB Europe3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
PDB (PDBSum)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
PDB (IMB)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
Structural Biology KnowledgeBase3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
SCOP (Structural Classification of Proteins)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
CATH (Classification of proteins structures)3FRR    3FRS    3JC1    4U7E    4U7I    4U7Y    4WZX    6E8G    6TZ4    6TZ5    6TZA   
SuperfamilyP53990
AlphaFold pdb e-kbP53990   
Human Protein Atlas [tissue]ENSG00000182149-IST1 [tissue]
HPRD13784
Protein Interaction databases
DIP (DOE-UCLA)P53990
IntAct (EBI)P53990
BioGRIDIST1
STRING (EMBL)IST1
ZODIACIST1
Ontologies - Pathways
QuickGOP53990
Ontology : AmiGOchromatin  protein binding  extracellular region  nuclear envelope  endoplasmic reticulum-Golgi intermediate compartment  centrosome  cytosol  cytosol  mitotic nuclear membrane reassembly  protein localization  protein localization  abscission  abscission  protein transport  viral release from host cell  protein domain specific binding  midbody  azurophil granule lumen  multivesicular body assembly  intracellular membrane-bounded organelle  neutrophil degranulation  protein-containing complex binding  establishment of protein localization  cadherin binding  positive regulation of proteolysis  viral capsid secondary envelopment  positive regulation of collateral sprouting  cell division  cytoskeleton-dependent cytokinesis  extracellular exosome  MIT domain binding  Flemming body  ESCRT III complex disassembly  
Ontology : EGO-EBIchromatin  protein binding  extracellular region  nuclear envelope  endoplasmic reticulum-Golgi intermediate compartment  centrosome  cytosol  cytosol  mitotic nuclear membrane reassembly  protein localization  protein localization  abscission  abscission  protein transport  viral release from host cell  protein domain specific binding  midbody  azurophil granule lumen  multivesicular body assembly  intracellular membrane-bounded organelle  neutrophil degranulation  protein-containing complex binding  establishment of protein localization  cadherin binding  positive regulation of proteolysis  viral capsid secondary envelopment  positive regulation of collateral sprouting  cell division  cytoskeleton-dependent cytokinesis  extracellular exosome  MIT domain binding  Flemming body  ESCRT III complex disassembly  
NDEx NetworkIST1
Atlas of Cancer Signalling NetworkIST1
Wikipedia pathwaysIST1
Orthology - Evolution
OrthoDB9798
GeneTree (enSembl)ENSG00000182149
Phylogenetic Trees/Animal Genes : TreeFamIST1
Homologs : HomoloGeneIST1
Homology/Alignments : Family Browser (UCSC)IST1
Gene fusions - Rearrangements
Fusion : QuiverIST1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IST1
dbVarIST1
ClinVarIST1
MonarchIST1
1000_GenomesIST1 
Exome Variant ServerIST1
GNOMAD BrowserENSG00000182149
Varsome BrowserIST1
ACMGIST1 variants
VarityP53990
Genomic Variants (DGV)IST1 [DGVbeta]
DECIPHERIST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIST1 
Mutations
ICGC Data PortalIST1 
TCGA Data PortalIST1 
Broad Tumor PortalIST1
OASIS PortalIST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIST1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIST1
Mutations and Diseases : HGMDIST1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIST1
DgiDB (Drug Gene Interaction Database)IST1
DoCM (Curated mutations)IST1
CIViC (Clinical Interpretations of Variants in Cancer)IST1
Cancer3DIST1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616434   
Orphanet
DisGeNETIST1
MedgenIST1
Genetic Testing Registry IST1
NextProtP53990 [Medical]
GENETestsIST1
Target ValidationIST1
Huge Navigator IST1 [HugePedia]
ClinGenIST1
Clinical trials, drugs, therapy
MyCancerGenomeIST1
Protein Interactions : CTDIST1
Pharm GKB GenePA142671633
PharosP53990
Clinical trialIST1
Miscellaneous
canSAR (ICR)IST1
HarmonizomeIST1
DataMed IndexIST1
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:16 CEST 2021

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