ISX (intestine specific homeobox)

2014-08-01 Affiliation

Identity

HGNC

ISX

LOCATION

22q12.3

LOCUSID

91464

ALIAS

Pix-1,RAXLX

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 91464
MIM: 612019
HGNC: 28084
Ensembl: ENSG00000175329

Variants:

dbSNP: 91464
ClinVar: 91464
TCGA: ENSG00000175329
COSMIC: ISX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175329	ENST00000308700	Q2M1V0
ENSG00000175329	ENST00000404699	Q2M1V0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
23393141	2013	Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.	37
23221382	2013	Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma.	9
27175585	2016	Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC.	7
28625979	2017	Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression.	7
26872890	2016	Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.	5
28398627	2017	Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression.	2

Citation

Dessen P

ISX (intestine specific homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54387/isx