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ISYNA1 (inositol-3-phosphate synthase 1)

Identity

Alias_symbol (synonym)Ino1
INOS
IPS
Other aliasINO1
IPS 1
IPS-1
HGNC (Hugo) ISYNA1
LocusID (NCBI) 51477
Atlas_Id 40998
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18434388 and ends at 18438301 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ISYNA1 (19p13.11) / CSH1 (17q23.3)ISYNA1 (19p13.11) / CSH2 (17q23.3)ISYNA1 (19p13.11) / NCDN (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ISYNA1   29821
Cards
Entrez_Gene (NCBI)ISYNA1  51477  inositol-3-phosphate synthase 1
AliasesINO1; INOS; IPS; IPS; 
IPS-1
GeneCards (Weizmann)ISYNA1
Ensembl hg19 (Hinxton)ENSG00000105655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105655 [Gene_View]  chr19:18434388-18438301 [Contig_View]  ISYNA1 [Vega]
ICGC DataPortalENSG00000105655
TCGA cBioPortalISYNA1
AceView (NCBI)ISYNA1
Genatlas (Paris)ISYNA1
WikiGenes51477
SOURCE (Princeton)ISYNA1
Genetics Home Reference (NIH)ISYNA1
Genomic and cartography
GoldenPath hg38 (UCSC)ISYNA1  -     chr19:18434388-18438301 -  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ISYNA1  -     19p13.11   [Description]    (hg19-Feb_2009)
EnsemblISYNA1 - 19p13.11 [CytoView hg19]  ISYNA1 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIISYNA1 [Mapview hg19]  ISYNA1 [Mapview hg38]
OMIM611670   
Gene and transcription
Genbank (Entrez)AF086921 AF207640 AF220530 AI983065 AK001325
RefSeq transcript (Entrez)NM_001170938 NM_001170939 NM_001253389 NM_016368
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ISYNA1
Cluster EST : UnigeneHs.405873 [ NCBI ]
CGAP (NCI)Hs.405873
Alternative Splicing GalleryENSG00000105655
Gene ExpressionISYNA1 [ NCBI-GEO ]   ISYNA1 [ EBI - ARRAY_EXPRESS ]   ISYNA1 [ SEEK ]   ISYNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)ISYNA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51477
GTEX Portal (Tissue expression)ISYNA1
Human Protein AtlasENSG00000105655-ISYNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPH2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPH2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPH2
Splice isoforms : SwissVarQ9NPH2
Catalytic activity : Enzyme5.5.1.4 [ Enzyme-Expasy ]   5.5.1.45.5.1.4 [ IntEnz-EBI ]   5.5.1.4 [ BRENDA ]   5.5.1.4 [ KEGG ]   
PhosPhoSitePlusQ9NPH2
Domains : Interpro (EBI)Myo-inos-1-P_Synthase    Myo-inos-1-P_Synthase_GAPDH    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)Inos-1-P_synth (PF01658)    NAD_binding_5 (PF07994)   
Domain families : Pfam (NCBI)pfam01658    pfam07994   
Conserved Domain (NCBI)ISYNA1
DMDM Disease mutations51477
Blocks (Seattle)ISYNA1
SuperfamilyQ9NPH2
Human Protein Atlas [tissue]ENSG00000105655-ISYNA1 [tissue]
Peptide AtlasQ9NPH2
HPRD17163
IPIIPI00549569   IPI00640098   IPI01009610   IPI00478861   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPH2
IntAct (EBI)Q9NPH2
FunCoupENSG00000105655
BioGRIDISYNA1
STRING (EMBL)ISYNA1
ZODIACISYNA1
Ontologies - Pathways
QuickGOQ9NPH2
Ontology : AmiGOinositol-3-phosphate synthase activity  inositol-3-phosphate synthase activity  protein binding  cytoplasm  cytosol  inositol biosynthetic process  inositol biosynthetic process  phospholipid biosynthetic process  inositol phosphate metabolic process  
Ontology : EGO-EBIinositol-3-phosphate synthase activity  inositol-3-phosphate synthase activity  protein binding  cytoplasm  cytosol  inositol biosynthetic process  inositol biosynthetic process  phospholipid biosynthetic process  inositol phosphate metabolic process  
Pathways : KEGGInositol phosphate metabolism   
NDEx NetworkISYNA1
Atlas of Cancer Signalling NetworkISYNA1
Wikipedia pathwaysISYNA1
Orthology - Evolution
OrthoDB51477
GeneTree (enSembl)ENSG00000105655
Phylogenetic Trees/Animal Genes : TreeFamISYNA1
HOVERGENQ9NPH2
HOGENOMQ9NPH2
Homologs : HomoloGeneISYNA1
Homology/Alignments : Family Browser (UCSC)ISYNA1
Gene fusions - Rearrangements
Tumor Fusion PortalISYNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerISYNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ISYNA1
dbVarISYNA1
ClinVarISYNA1
1000_GenomesISYNA1 
Exome Variant ServerISYNA1
ExAC (Exome Aggregation Consortium)ENSG00000105655
GNOMAD BrowserENSG00000105655
Genetic variants : HAPMAP51477
Genomic Variants (DGV)ISYNA1 [DGVbeta]
DECIPHERISYNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisISYNA1 
Mutations
ICGC Data PortalISYNA1 
TCGA Data PortalISYNA1 
Broad Tumor PortalISYNA1
OASIS PortalISYNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICISYNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDISYNA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ISYNA1
DgiDB (Drug Gene Interaction Database)ISYNA1
DoCM (Curated mutations)ISYNA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ISYNA1 (select a term)
intoGenISYNA1
Cancer3DISYNA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611670   
Orphanet
DisGeNETISYNA1
MedgenISYNA1
Genetic Testing Registry ISYNA1
NextProtQ9NPH2 [Medical]
TSGene51477
GENETestsISYNA1
Target ValidationISYNA1
Huge Navigator ISYNA1 [HugePedia]
snp3D : Map Gene to Disease51477
BioCentury BCIQISYNA1
ClinGenISYNA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51477
Chemical/Pharm GKB GenePA164721116
Clinical trialISYNA1
Miscellaneous
canSAR (ICR)ISYNA1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineISYNA1
EVEXISYNA1
GoPubMedISYNA1
iHOPISYNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:18:10 CET 2017

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