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ITCH (itchy E3 ubiquitin protein ligase)

Identity

Alias (NCBI)ADMFD
AIF4
AIP4
NAPP1
HGNC (Hugo) ITCH
HGNC Alias symbAIP4
HGNC Previous nameitchy (mouse homolog) E3 ubiquitin protein ligase
 itchy E3 ubiquitin protein ligase homolog (mouse)
LocusID (NCBI) 83737
Atlas_Id 43875
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34363273 and ends at 34511773 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AXIN1 (16p13.3) / ITCH (20q11.22)DHX35 (20q11.23) / ITCH (20q11.22)ITCH (20q11.22) / AHCY (20q11.22)
ITCH (20q11.22) / ASIP (20q11.22)ITCH (20q11.22) / DEFB118 (20q11.21)ITCH (20q11.22) / DYNLRB1 (20q11.22)
ITCH (20q11.22) / MYL9 (20q11.23)ITCH (20q11.22) / PIGU (20q11.22)ITCH (20q11.22) / RALY (20q11.22)
ITCH (20q11.22) / TAB1 (22q13.1)ITCH (20q11.22) / TSHZ2 (20q13.2)OAT (10q26.13) / ITCH (20q11.22)
PPM1H (12q14.1) / ITCH (20q11.22)PSPH (7p11.2) / ITCH (20q11.22)TSC22D1 (13q14.11) / ITCH (20q11.22)
AXIN1 16p13.3 / ITCH 20q11.22ITCH 20q11.22 / AHCY 20q11.22ITCH 20q11.22 / ASIP 20q11.22
ITCH 20q11.22 / DEFB118 20q11.21ITCH 20q11.22 / MYL9 20q11.23ITCH 20q11.22 / PIGU 20q11.22
ITCH 20q11.22 / RALY 20q11.22ITCH 20q11.22 / TAB1 22q13.1ITCH 20q11.22 / TSHZ2 20q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(20;20)(q11;q11) ITCH/RPRD1B


External links

Nomenclature
HGNC (Hugo)ITCH   13890
LRG (Locus Reference Genomic)LRG_354
Cards
Entrez_Gene (NCBI)ITCH    itchy E3 ubiquitin protein ligase
AliasesADMFD; AIF4; AIP4; NAPP1
GeneCards (Weizmann)ITCH
Ensembl hg19 (Hinxton)ENSG00000078747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078747 [Gene_View]  ENSG00000078747 [Sequence]  chr20:34363273-34511773 [Contig_View]  ITCH [Vega]
ICGC DataPortalENSG00000078747
TCGA cBioPortalITCH
AceView (NCBI)ITCH
Genatlas (Paris)ITCH
SOURCE (Princeton)ITCH
Genetics Home Reference (NIH)ITCH
Genomic and cartography
GoldenPath hg38 (UCSC)ITCH  -     chr20:34363273-34511773 +  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITCH  -     20q11.22   [Description]    (hg19-Feb_2009)
GoldenPathITCH - 20q11.22 [CytoView hg19]  ITCH - 20q11.22 [CytoView hg38]
ImmunoBaseENSG00000078747
genome Data Viewer NCBIITCH [Mapview hg19]  
OMIM606409   613385   
Gene and transcription
Genbank (Entrez)AA730741 AB056663 AB209747 AF038564 AF095745
RefSeq transcript (Entrez)NM_001257137 NM_001257138 NM_001324197 NM_001324198 NM_031483
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITCH
Alternative Splicing GalleryENSG00000078747
Gene ExpressionITCH [ NCBI-GEO ]   ITCH [ EBI - ARRAY_EXPRESS ]   ITCH [ SEEK ]   ITCH [ MEM ]
Gene Expression Viewer (FireBrowse)ITCH [ Firebrowse - Broad ]
GenevisibleExpression of ITCH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83737
GTEX Portal (Tissue expression)ITCH
Human Protein AtlasENSG00000078747-ITCH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)ITCH
Blocks (Seattle)ITCH
Human Protein Atlas [tissue]ENSG00000078747-ITCH [tissue]
IPIIPI00061780   IPI00176010   IPI01010870   
Protein Interaction databases
BioGRIDITCH
STRING (EMBL)ITCH
ZODIACITCH
Ontologies - Pathways
Litterature
PubMed255 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXITCH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:27:05 CET 2021

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