ITCH (itchy E3 ubiquitin protein ligase homolog (mouse))

Identity

Other names	AIF4
	AIP4
	NAPP1
	dJ468O1.1
HGNC	ITCH
Location	20q11.22
Location_base_pair	Starts at 32414723 and ends at 32562858 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ITCH   13890
Entrez_Gene	ITCH  83737  itchy E3 ubiquitin protein ligase homolog (mouse)
	Cards
GeneCards	ITCH
Ensembl	ITCH [Search_View]   ENSG00000078747 [Gene_View]
Genatlas	ITCH
GeneLynx	ITCH
eGenome	ITCH
euGene	83737
	Genomic and cartography
GoldenPath	ITCH  -  20q11.22   chr20:32414723-32562858 +  20q11.22   [Description]    (hg18-March_2006)
Ensembl	ITCH - 20q11.22 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ITCH
	Gene and transcription
Genbank	AB056663 [ ENTREZ ]
Genbank	AB209747 [ ENTREZ ]
Genbank	AF038564 [ ENTREZ ]
Genbank	AF095745 [ ENTREZ ]
Genbank	AK315212 [ ENTREZ ]
RefSeq	NM_031483 [ SRS ]    NM_031483 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_028392 [ SRS ]    NT_028392 [ ENTREZ ]
RefSeq	NW_001838664 [ SRS ]    NW_001838664 [ ENTREZ ]
RefSeq	NW_927339 [ SRS ]    NW_927339 [ ENTREZ ]
AceView	ITCH AceView - NCBI
Unigene	Hs.632272 [ SRS ]    Hs.632272 [ NCBI ]     HS632272 [ spliceNest ]
Fast-db	8769 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q59ER4 [ SRS]    Q59ER4 [ EXPASY ]     Q59ER4 [ INTERPRO ]     Q59ER4 [ UNIPROT ]
Prosite	PS50237 HECT [ SRS ]    PS50237 HECT [ Expasy ]
Prosite	PS01159 WW_DOMAIN_1 [ SRS ]    PS01159 WW_DOMAIN_1 [ Expasy ]
Prosite	PS50020 WW_DOMAIN_2 [ SRS ]    PS50020 WW_DOMAIN_2 [ Expasy ]
Interpro	IPR000569 HECT [ SRS ]    IPR000569 HECT [ EBI ]
Interpro	IPR002349 WW [ SRS ]    IPR002349 WW [ EBI ]
Interpro	IPR001202 WW_Rsp5_WWP [ SRS ]    IPR001202 WW_Rsp5_WWP [ EBI ]
CluSTr	Q59ER4
Pfam	PF00632 HECT [ SRS ]    PF00632 HECT [ Sanger ]    pfam00632 [ NCBI-CDD ]
Pfam	PF00397 WW [ SRS ]    PF00397 WW [ Sanger ]    pfam00397 [ NCBI-CDD ]
Smart	SM00119 HECTc [EMBL]
Smart	SM00456 WW [EMBL]
Blocks	Q59ER4
	Protein Interaction databases
DIP	Q59ER4
IntAct	Q59ER4
	Polymorphism : SNP, mutations, diseases
OMIM	606409    [ map ]
GENECLINICS	606409
SNP	ITCH [dbSNP-NCBI]
SNP	NM_031483 [SNP-NCI]
SNP	ITCH [GeneSNPs - Utah]  ITCH] [HGBASE - SRS]
HAPMAP	ITCH [HAPMAP]
COSMIC	ITCH [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ITCH
	General knowledge
Family Browser	ITCH [UCSC Family Browser]
SOURCE	NM_031483
SMD	Hs.632272
SAGE	Hs.632272
GO	regulation of cell growth [Amigo]  regulation of cell growth
GO	ubiquitin-protein ligase activity [Amigo]  ubiquitin-protein ligase activity
GO	protein binding [Amigo]  protein binding
GO	cellular_component [Amigo]  cellular_component
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	protein modification process [Amigo]  protein modification process
GO	ubiquitin-dependent protein catabolic process [Amigo]  ubiquitin-dependent protein catabolic process
GO	inflammatory response [Amigo]  inflammatory response
GO	ligase activity [Amigo]  ligase activity
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	entry of virus into host cell [Amigo]  entry of virus into host cell
KEGG	Ubiquitin mediated proteolysis
KEGG	Dentatorubropallidoluysian atrophy (DRPLA)
PubGene	ITCH
TreeFam	ITCH
CTD	83737 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ITCH Related clones (RZPD - Berlin)
	PubMed
PubMed	30 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:46:59 2008