Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ITGA2 (integrin subunit alpha 2)

Identity

Alias_namesCD49B
integrin
Alias_symbol (synonym)CD49b
Other aliasBR
GPIa
HPA-5
VLA-2
VLAA2
HGNC (Hugo) ITGA2
LocusID (NCBI) 3673
Atlas_Id 41002
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 52989326 and ends at 53094779 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ITGA2 (5q11.2) / ITGA2 (5q11.2)ITGA2 (5q11.2) / MIR31HG (9p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGA2   6137
LRG (Locus Reference Genomic)LRG_1001
Cards
Entrez_Gene (NCBI)ITGA2  3673  integrin subunit alpha 2
AliasesBR; CD49B; GPIa; HPA-5; 
VLA-2; VLAA2
GeneCards (Weizmann)ITGA2
Ensembl hg19 (Hinxton)ENSG00000164171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164171 [Gene_View]  chr5:52989326-53094779 [Contig_View]  ITGA2 [Vega]
ICGC DataPortalENSG00000164171
TCGA cBioPortalITGA2
AceView (NCBI)ITGA2
Genatlas (Paris)ITGA2
WikiGenes3673
SOURCE (Princeton)ITGA2
Genetics Home Reference (NIH)ITGA2
Genomic and cartography
GoldenPath hg38 (UCSC)ITGA2  -     chr5:52989326-53094779 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGA2  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblITGA2 - 5q11.2 [CytoView hg19]  ITGA2 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIITGA2 [Mapview hg19]  ITGA2 [Mapview hg38]
OMIM192974   614200   
Gene and transcription
Genbank (Entrez)AK307952 AU126174 BC143505 BC143508 BC143509
RefSeq transcript (Entrez)NM_002203
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGA2
Cluster EST : UnigeneHs.482077 [ NCBI ]
CGAP (NCI)Hs.482077
Alternative Splicing GalleryENSG00000164171
Gene ExpressionITGA2 [ NCBI-GEO ]   ITGA2 [ EBI - ARRAY_EXPRESS ]   ITGA2 [ SEEK ]   ITGA2 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3673
GTEX Portal (Tissue expression)ITGA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17301   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17301  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17301
Splice isoforms : SwissVarP17301
PhosPhoSitePlusP17301
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)    VWFA (PS50234)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_dom    VWF_A   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha2 (PF08441)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam01839    pfam08441    pfam00092   
Domain families : Smart (EMBL)Int_alpha (SM00191)  VWA (SM00327)  
Conserved Domain (NCBI)ITGA2
DMDM Disease mutations3673
Blocks (Seattle)ITGA2
PDB (SRS)1AOX    1DZI    1PQB    1V7P    4BJ3   
PDB (PDBSum)1AOX    1DZI    1PQB    1V7P    4BJ3   
PDB (IMB)1AOX    1DZI    1PQB    1V7P    4BJ3   
PDB (RSDB)1AOX    1DZI    1PQB    1V7P    4BJ3   
Structural Biology KnowledgeBase1AOX    1DZI    1PQB    1V7P    4BJ3   
SCOP (Structural Classification of Proteins)1AOX    1DZI    1PQB    1V7P    4BJ3   
CATH (Classification of proteins structures)1AOX    1DZI    1PQB    1V7P    4BJ3   
SuperfamilyP17301
Human Protein AtlasENSG00000164171
Peptide AtlasP17301
HPRD01893
IPIIPI00013744   IPI00968223   IPI00966789   IPI00964626   IPI00964154   IPI00967476   
Protein Interaction databases
DIP (DOE-UCLA)P17301
IntAct (EBI)P17301
FunCoupENSG00000164171
BioGRIDITGA2
STRING (EMBL)ITGA2
ZODIACITGA2
Ontologies - Pathways
QuickGOP17301
Ontology : AmiGOvirus receptor activity  response to hypoxia  positive regulation of leukocyte migration  integrin binding  protein binding  collagen binding  nucleus  plasma membrane  plasma membrane  focal adhesion  substrate-dependent cell migration  hypotonic response  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  female pregnancy  blood coagulation  cell proliferation  integrin complex  animal organ morphogenesis  external side of plasma membrane  cell surface  positive regulation of epithelial cell migration  positive regulation of alkaline phosphatase activity  response to amine  response to muscle activity  positive regulation of smooth muscle cell migration  extracellular matrix organization  axon  mammary gland development  positive regulation of cell projection organization  cell-substrate adhesion  protein complex binding  positive regulation of collagen biosynthetic process  positive regulation of collagen binding  response to L-ascorbic acid  cell adhesion mediated by integrin  integrin alpha2-beta1 complex  collagen receptor activity  collagen-activated signaling pathway  response to drug  laminin binding  positive regulation of DNA binding  skin morphogenesis  axon terminus  basal part of cell  establishment of protein localization  positive regulation of translation  positive regulation of cell adhesion  positive regulation of smooth muscle contraction  viral entry into host cell  metal ion binding  protein heterodimerization activity  focal adhesion assembly  mesodermal cell differentiation  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of positive chemotaxis  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of transmission of nerve impulse  positive regulation of phagocytosis, engulfment  hepatocyte differentiation  response to parathyroid hormone  cellular response to mechanical stimulus  cellular response to estradiol stimulus  collagen binding involved in cell-matrix adhesion  
Ontology : EGO-EBIvirus receptor activity  response to hypoxia  positive regulation of leukocyte migration  integrin binding  protein binding  collagen binding  nucleus  plasma membrane  plasma membrane  focal adhesion  substrate-dependent cell migration  hypotonic response  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  female pregnancy  blood coagulation  cell proliferation  integrin complex  animal organ morphogenesis  external side of plasma membrane  cell surface  positive regulation of epithelial cell migration  positive regulation of alkaline phosphatase activity  response to amine  response to muscle activity  positive regulation of smooth muscle cell migration  extracellular matrix organization  axon  mammary gland development  positive regulation of cell projection organization  cell-substrate adhesion  protein complex binding  positive regulation of collagen biosynthetic process  positive regulation of collagen binding  response to L-ascorbic acid  cell adhesion mediated by integrin  integrin alpha2-beta1 complex  collagen receptor activity  collagen-activated signaling pathway  response to drug  laminin binding  positive regulation of DNA binding  skin morphogenesis  axon terminus  basal part of cell  establishment of protein localization  positive regulation of translation  positive regulation of cell adhesion  positive regulation of smooth muscle contraction  viral entry into host cell  metal ion binding  protein heterodimerization activity  focal adhesion assembly  mesodermal cell differentiation  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  positive regulation of inflammatory response  positive regulation of positive chemotaxis  detection of mechanical stimulus involved in sensory perception of pain  positive regulation of transmission of nerve impulse  positive regulation of phagocytosis, engulfment  hepatocyte differentiation  response to parathyroid hormone  cellular response to mechanical stimulus  cellular response to estradiol stimulus  collagen binding involved in cell-matrix adhesion  
Pathways : KEGG   
NDEx NetworkITGA2
Atlas of Cancer Signalling NetworkITGA2
Wikipedia pathwaysITGA2
Orthology - Evolution
OrthoDB3673
GeneTree (enSembl)ENSG00000164171
Phylogenetic Trees/Animal Genes : TreeFamITGA2
HOVERGENP17301
HOGENOMP17301
Homologs : HomoloGeneITGA2
Homology/Alignments : Family Browser (UCSC)ITGA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA2
dbVarITGA2
ClinVarITGA2
1000_GenomesITGA2 
Exome Variant ServerITGA2
ExAC (Exome Aggregation Consortium)ITGA2 (select the gene name)
Genetic variants : HAPMAP3673
Genomic Variants (DGV)ITGA2 [DGVbeta]
DECIPHERITGA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGA2 
Mutations
ICGC Data PortalITGA2 
TCGA Data PortalITGA2 
Broad Tumor PortalITGA2
OASIS PortalITGA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGA2
DgiDB (Drug Gene Interaction Database)ITGA2
DoCM (Curated mutations)ITGA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGA2 (select a term)
intoGenITGA2
Cancer3DITGA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM192974    614200   
Orphanet8692   
MedgenITGA2
Genetic Testing Registry ITGA2
NextProtP17301 [Medical]
TSGene3673
GENETestsITGA2
Target ValidationITGA2
Huge Navigator ITGA2 [HugePedia]
snp3D : Map Gene to Disease3673
BioCentury BCIQITGA2
ClinGenITGA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3673
Chemical/Pharm GKB GenePA204
Clinical trialITGA2
Miscellaneous
canSAR (ICR)ITGA2 (select the gene name)
Probes
Litterature
PubMed391 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGA2
EVEXITGA2
GoPubMedITGA2
iHOPITGA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:52 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.