Identity
HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
BR,CD49B,GPIa,HPA-5,VLA-2,VLAA2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3673
MIM: 192974
HGNC: 6137
Ensembl: ENSG00000164171
Variants:
dbSNP: 3673
ClinVar: 3673
TCGA: ENSG00000164171
COSMIC: ITGA2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA26716 | COL3A1 | Gene | Pathway | associated | 20938371 | ||
| PA26717 | COL4A1 | Gene | Pathway | associated | 20938371 | ||
| PA26718 | COL4A2 | Gene | Pathway | associated | 20938371 | ||
| PA33384 | PLCB1 | Gene | Pathway | associated | 20938371 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20938371 | ||
| PA35041 | COL1A1 | Gene | Pathway | associated | 20938371 | ||
| PA35042 | COL1A2 | Gene | Pathway | associated | 20938371 | ||
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 15205592, 16214444, 16493486, 17157856, 22940005 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 15205592, 16214444, 16493486, 17157856, 22940005 | |
| PA445019 | Myocardial Infarction | Disease | ClinicalAnnotation | associated | PD | 15205592, 16214444, 16493486, 17157856, 22940005 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | 15205592, 16214444, 16493486, 17157856, 22940005 | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation | associated | PD | 15205592, 16214444, 16493486, 17157856, 22940005 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37804164 | 2024 | Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity. | 0 |
| 38142122 | 2024 | ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation. | 0 |
| 37804164 | 2024 | Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity. | 0 |
| 38142122 | 2024 | ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation. | 0 |
| 36151049 | 2023 | Integrin alpha 2 is associated with tumor progression and postoperative recurrence in non-small cell lung cancer. | 2 |
| 36420922 | 2023 | Hypomethylation-mediated overexpression of ITGA2 stimulates cell invasion and migration of thyroid carcinoma. | 0 |
| 36766725 | 2023 | Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells. | 0 |
| 37311571 | 2023 | BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2. | 0 |
| 37881431 | 2023 | High expression ITGA2 affects the expression of MET, PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients. | 0 |
| 37907515 | 2023 | SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN. | 2 |
| 36151049 | 2023 | Integrin alpha 2 is associated with tumor progression and postoperative recurrence in non-small cell lung cancer. | 2 |
| 36420922 | 2023 | Hypomethylation-mediated overexpression of ITGA2 stimulates cell invasion and migration of thyroid carcinoma. | 0 |
| 36766725 | 2023 | Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells. | 0 |
| 37311571 | 2023 | BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2. | 0 |
| 37881431 | 2023 | High expression ITGA2 affects the expression of MET, PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients. | 0 |
Citation
Dessen P
ITGA2 (integrin subunit alpha 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41002/itga2
