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ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41))

Identity

Other namesBDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
PPP1R93
HGNC (Hugo) ITGA2B
LocusID (NCBI) 3674
Location 17q21.31
Location_base_pair Starts at 42449550 and ends at 42466873 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGA2B   6138
Cards
Entrez_Gene (NCBI)ITGA2B  3674  integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
GeneCards (Weizmann)ITGA2B
Ensembl (Hinxton)ENSG00000005961 [Gene_View]  chr17:42449550-42466873 [Contig_View]  ITGA2B [Vega]
ICGC DataPortalENSG00000005961
AceView (NCBI)ITGA2B
Genatlas (Paris)ITGA2B
WikiGenes3674
SOURCE (Princeton)NM_000419
Genomic and cartography
GoldenPath (UCSC)ITGA2B  -  17q21.31   chr17:42449550-42466873 -  17q21.31   [Description]    (hg19-Feb_2009)
EnsemblITGA2B - 17q21.31 [CytoView]
Mapping of homologs : NCBIITGA2B [Mapview]
OMIM187800   273800   607759   
Gene and transcription
Genbank (Entrez)AB209552 AF098114 AK297155 AK303081 AK315335
RefSeq transcript (Entrez)NM_000419
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_008331 NT_010783 NW_001838437 NW_004929407
Consensus coding sequences : CCDS (NCBI)ITGA2B
Cluster EST : UnigeneHs.411312 [ NCBI ]
CGAP (NCI)Hs.411312
Alternative Splicing : Fast-db (Paris)GSHG0013450
Alternative Splicing GalleryENSG00000005961
Gene ExpressionITGA2B [ NCBI-GEO ]     ITGA2B [ SEEK ]   ITGA2B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08514 (Uniprot)
NextProtP08514  [Medical]
With graphics : InterProP08514
Splice isoforms : SwissVarP08514 (Swissvar)
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS   
Related proteins : CluSTrP08514
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
DMDM Disease mutations3674
Blocks (Seattle)P08514
PDB (SRS)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK   
PDB (PDBSum)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK   
PDB (IMB)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK   
PDB (RSDB)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK   
Human Protein AtlasENSG00000005961
Peptide AtlasP08514
HPRD06377
IPIIPI00295976   IPI00218628   IPI00218629   IPI00922182   
Protein Interaction databases
DIP (DOE-UCLA)P08514
IntAct (EBI)P08514
FunCoupENSG00000005961
BioGRIDITGA2B
InParanoidP08514
Interologous Interaction database P08514
IntegromeDBITGA2B
STRING (EMBL)ITGA2B
Ontologies - Pathways
Ontology : AmiGOplatelet degranulation  positive regulation of leukocyte migration  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  axon guidance  blood coagulation  integrin complex  external side of plasma membrane  platelet activation  extracellular matrix organization  platelet alpha granule membrane  identical protein binding  metal ion binding  extracellular matrix binding  fibrinogen binding  platelet aggregation  blood microparticle  
Ontology : EGO-EBIplatelet degranulation  positive regulation of leukocyte migration  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  axon guidance  blood coagulation  integrin complex  external side of plasma membrane  platelet activation  extracellular matrix organization  platelet alpha granule membrane  identical protein binding  metal ion binding  extracellular matrix binding  fibrinogen binding  platelet aggregation  blood microparticle  
Pathways : KEGGRap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Hematopoietic cell lineage    Regulation of actin cytoskeleton    Pathways in cancer    Small cell lung cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
Protein Interaction DatabaseITGA2B
Wikipedia pathwaysITGA2B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ITGA2B
SNP (GeneSNP Utah)ITGA2B
SNP : HGBaseITGA2B
Genetic variants : HAPMAPITGA2B
1000_GenomesITGA2B 
ICGC programENSG00000005961 
CONAN: Copy Number AnalysisITGA2B 
Somatic Mutations in Cancer : COSMICITGA2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
Mutations and Diseases : HGMDITGA2B
OMIM187800    273800    607759   
MedgenITGA2B
GENETestsITGA2B
Disease Genetic AssociationITGA2B
Huge Navigator ITGA2B [HugePedia]  ITGA2B [HugeCancerGEM]
Genomic VariantsITGA2B  ITGA2B [DGVbeta]
Exome VariantITGA2B
dbVarITGA2B
ClinVarITGA2B
snp3D : Map Gene to Disease3674
General knowledge
Homologs : HomoloGeneITGA2B
Homology/Alignments : Family Browser (UCSC)ITGA2B
Phylogenetic Trees/Animal Genes : TreeFamITGA2B
Chemical/Protein Interactions : CTD3674
Chemical/Pharm GKB GenePA29938
Clinical trialITGA2B
Cancer Resource (Charite)ENSG00000005961
Other databases
Probes
Litterature
PubMed348 Pubmed reference(s) in Entrez
CoreMineITGA2B
iHOPITGA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:53:40 CEST 2014

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