Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ITGA2B (integrin subunit alpha 2b)

Identity

Other namesBDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
PPP1R93
HGNC (Hugo) ITGA2B
LocusID (NCBI) 3674
Atlas_Id 41003
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 42449549 and ends at 42466969 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARL8B (3p26.1) / ITGA2B (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGA2B   6138
Cards
Entrez_Gene (NCBI)ITGA2B  3674  integrin subunit alpha 2b
AliasesBDPLT16; BDPLT2; CD41; CD41B; 
GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
GeneCards (Weizmann)ITGA2B
Ensembl hg19 (Hinxton)ENSG00000005961 [Gene_View]  chr17:42449549-42466969 [Contig_View]  ITGA2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000005961 [Gene_View]  chr17:42449549-42466969 [Contig_View]  ITGA2B [Vega]
ICGC DataPortalENSG00000005961
TCGA cBioPortalITGA2B
AceView (NCBI)ITGA2B
Genatlas (Paris)ITGA2B
WikiGenes3674
SOURCE (Princeton)ITGA2B
Genomic and cartography
GoldenPath hg19 (UCSC)ITGA2B  -     chr17:42449549-42466969 -  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGA2B  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblITGA2B - 17q21.31 [CytoView hg19]  ITGA2B - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIITGA2B [Mapview hg19]  ITGA2B [Mapview hg38]
OMIM187800   273800   607759   
Gene and transcription
Genbank (Entrez)AB209552 AF098114 AK297155 AK303081 AK315335
RefSeq transcript (Entrez)NM_000419
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008331 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)ITGA2B
Cluster EST : UnigeneHs.411312 [ NCBI ]
CGAP (NCI)Hs.411312
Alternative Splicing GalleryENSG00000005961
Gene ExpressionITGA2B [ NCBI-GEO ]   ITGA2B [ EBI - ARRAY_EXPRESS ]   ITGA2B [ SEEK ]   ITGA2B [ MEM ]
Gene Expression Viewer (FireBrowse)ITGA2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3674
GTEX Portal (Tissue expression)ITGA2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08514 (Uniprot)
NextProtP08514  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08514
Splice isoforms : SwissVarP08514 (Swissvar)
PhosPhoSitePlusP08514
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_dom   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
DMDM Disease mutations3674
Blocks (Seattle)ITGA2B
PDB (SRS)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (PDBSum)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (IMB)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (RSDB)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
Structural Biology KnowledgeBase1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
SCOP (Structural Classification of Proteins)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
CATH (Classification of proteins structures)1DPK    1DPQ    1JX5    1KUP    1KUZ    1M8O    1RN0    1S4W    1TYE    1UV9    2K1A    2K9J    2KNC    2MTP    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4Z7N    4Z7O    4Z7Q    5HDB   
SuperfamilyP08514
Human Protein AtlasENSG00000005961
Peptide AtlasP08514
HPRD06377
IPIIPI00295976   IPI00218628   IPI00218629   IPI00922182   
Protein Interaction databases
DIP (DOE-UCLA)P08514
IntAct (EBI)P08514
FunCoupENSG00000005961
BioGRIDITGA2B
STRING (EMBL)ITGA2B
ZODIACITGA2B
Ontologies - Pathways
QuickGOP08514
Ontology : AmiGOplatelet degranulation  positive regulation of leukocyte migration  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  external side of plasma membrane  cell surface  extracellular matrix organization  platelet alpha granule membrane  identical protein binding  metal ion binding  extracellular matrix binding  fibrinogen binding  extracellular exosome  platelet aggregation  blood microparticle  
Ontology : EGO-EBIplatelet degranulation  positive regulation of leukocyte migration  protein binding  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  external side of plasma membrane  cell surface  extracellular matrix organization  platelet alpha granule membrane  identical protein binding  metal ion binding  extracellular matrix binding  fibrinogen binding  extracellular exosome  platelet aggregation  blood microparticle  
Pathways : KEGGRap1 signaling pathway    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Hematopoietic cell lineage    Regulation of actin cytoskeleton    Pathways in cancer    Small cell lung cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGA2B
Atlas of Cancer Signalling NetworkITGA2B
Wikipedia pathwaysITGA2B
Orthology - Evolution
OrthoDB3674
GeneTree (enSembl)ENSG00000005961
Phylogenetic Trees/Animal Genes : TreeFamITGA2B
Homologs : HomoloGeneITGA2B
Homology/Alignments : Family Browser (UCSC)ITGA2B
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerITGA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA2B
dbVarITGA2B
ClinVarITGA2B
1000_GenomesITGA2B 
Exome Variant ServerITGA2B
ExAC (Exome Aggregation Consortium)ITGA2B (select the gene name)
Genetic variants : HAPMAP3674
Genomic Variants (DGV)ITGA2B [DGVbeta]
Mutations
ICGC Data PortalITGA2B 
TCGA Data PortalITGA2B 
Broad Tumor PortalITGA2B
OASIS PortalITGA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGA2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch ITGA2B
DgiDB (Drug Gene Interaction Database)ITGA2B
DoCM (Curated mutations)ITGA2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGA2B (select a term)
intoGenITGA2B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:42449549-42466969  ENSG00000005961
CONAN: Copy Number AnalysisITGA2B 
Mutations and Diseases : HGMDITGA2B
OMIM187800    273800    607759   
MedgenITGA2B
Genetic Testing Registry ITGA2B
NextProtP08514 [Medical]
TSGene3674
GENETestsITGA2B
Huge Navigator ITGA2B [HugePedia]
snp3D : Map Gene to Disease3674
BioCentury BCIQITGA2B
ClinGenITGA2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3674
Chemical/Pharm GKB GenePA29938
Clinical trialITGA2B
Miscellaneous
canSAR (ICR)ITGA2B (select the gene name)
Probes
Litterature
PubMed364 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGA2B
EVEXITGA2B
GoPubMedITGA2B
iHOPITGA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:55:31 CEST 2016

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