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ITGA5 (integrin, alpha 5 (fibronectin receptor, alpha polypeptide))

Identity

Other namesCD49e
FNRA
VLA5A
HGNC (Hugo) ITGA5
LocusID (NCBI) 3678
Location 12q13.13
Location_base_pair Starts at 54789045 and ends at 54813050 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGA5   6141
Cards
Entrez_Gene (NCBI)ITGA5  3678  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
GeneCards (Weizmann)ITGA5
Ensembl hg19 (Hinxton)ENSG00000161638 [Gene_View]  chr12:54789045-54813050 [Contig_View]  ITGA5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161638 [Gene_View]  chr12:54789045-54813050 [Contig_View]  ITGA5 [Vega]
ICGC DataPortalENSG00000161638
cBioPortalITGA5
AceView (NCBI)ITGA5
Genatlas (Paris)ITGA5
WikiGenes3678
SOURCE (Princeton)ITGA5
Genomic and cartography
GoldenPath hg19 (UCSC)ITGA5  -     chr12:54789045-54813050 -  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGA5  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblITGA5 - 12q13.13 [CytoView hg19]  ITGA5 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIITGA5 [Mapview hg19]  ITGA5 [Mapview hg38]
OMIM135620   
Gene and transcription
Genbank (Entrez)AK291570 AK304696 AK311051 AK312414 AU133210
RefSeq transcript (Entrez)NM_002205
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_029419 NW_001838059 NW_004929384
Consensus coding sequences : CCDS (NCBI)ITGA5
Cluster EST : UnigeneHs.505654 [ NCBI ]
CGAP (NCI)Hs.505654
Alternative Splicing : Fast-db (Paris)GSHG0007526
Alternative Splicing GalleryENSG00000161638
Gene ExpressionITGA5 [ NCBI-GEO ]     ITGA5 [ SEEK ]   ITGA5 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08648 (Uniprot)
NextProtP08648  [Medical]
With graphics : InterProP08648
Splice isoforms : SwissVarP08648 (Swissvar)
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS   
Related proteins : CluSTrP08648
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
DMDM Disease mutations3678
Blocks (Seattle)P08648
PDB (SRS)3VI3    3VI4   
PDB (PDBSum)3VI3    3VI4   
PDB (IMB)3VI3    3VI4   
PDB (RSDB)3VI3    3VI4   
Human Protein AtlasENSG00000161638
Peptide AtlasP08648
HPRD00627
IPIIPI00306604   IPI00910512   IPI01020682   IPI01023060   
Protein Interaction databases
DIP (DOE-UCLA)P08648
IntAct (EBI)P08648
FunCoupENSG00000161638
BioGRIDITGA5
IntegromeDBITGA5
STRING (EMBL)ITGA5
Ontologies - Pathways
QuickGOP08648
Ontology : AmiGOangiogenesis  ruffle  epidermal growth factor receptor binding  platelet-derived growth factor receptor binding  integrin binding  protein binding  cytoplasm  plasma membrane  cell-cell junction  focal adhesion  cell-substrate junction assembly  cell adhesion  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  integrin-mediated signaling pathway  axon guidance  blood coagulation  memory  integrin complex  external side of plasma membrane  positive regulation of cell-substrate adhesion  viral process  extracellular matrix organization  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cell-substrate adhesion  ruffle membrane  cell-cell adhesion mediated by integrin  wound healing, spreading of epidermal cells  vascular endothelial growth factor receptor 2 binding  synapse  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  alphav-beta3 integrin-vitronectin complex  negative regulation of anoikis  
Ontology : EGO-EBIangiogenesis  ruffle  epidermal growth factor receptor binding  platelet-derived growth factor receptor binding  integrin binding  protein binding  cytoplasm  plasma membrane  cell-cell junction  focal adhesion  cell-substrate junction assembly  cell adhesion  heterophilic cell-cell adhesion  leukocyte cell-cell adhesion  integrin-mediated signaling pathway  axon guidance  blood coagulation  memory  integrin complex  external side of plasma membrane  positive regulation of cell-substrate adhesion  viral process  extracellular matrix organization  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cell-substrate adhesion  ruffle membrane  cell-cell adhesion mediated by integrin  wound healing, spreading of epidermal cells  vascular endothelial growth factor receptor 2 binding  synapse  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  alphav-beta3 integrin-vitronectin complex  negative regulation of anoikis  
Pathways : KEGGPhagosome    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Hematopoietic cell lineage    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Shigellosis    Pertussis    Proteoglycans in cancer    MicroRNAs in cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
Protein Interaction DatabaseITGA5
DoCM (Curated mutations)ITGA5
Wikipedia pathwaysITGA5
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerITGA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA5
dbVarITGA5
ClinVarITGA5
1000_GenomesITGA5 
Exome Variant ServerITGA5
SNP (GeneSNP Utah)ITGA5
SNP : HGBaseITGA5
Genetic variants : HAPMAPITGA5
Genomic VariantsITGA5  ITGA5 [DGVbeta]
Mutations
ICGC Data PortalENSG00000161638 
Somatic Mutations in Cancer : COSMICITGA5 
CONAN: Copy Number AnalysisITGA5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:54789045-54813050
Mutations and Diseases : HGMDITGA5
OMIM135620   
MedgenITGA5
NextProtP08648 [Medical]
GENETestsITGA5
Disease Genetic AssociationITGA5
Huge Navigator ITGA5 [HugePedia]  ITGA5 [HugeCancerGEM]
snp3D : Map Gene to Disease3678
DGIdb (Drug Gene Interaction db)ITGA5
General knowledge
Homologs : HomoloGeneITGA5
Homology/Alignments : Family Browser (UCSC)ITGA5
Phylogenetic Trees/Animal Genes : TreeFamITGA5
Chemical/Protein Interactions : CTD3678
Chemical/Pharm GKB GenePA29941
Clinical trialITGA5
Cancer Resource (Charite)ENSG00000161638
Other databases
Probes
Litterature
PubMed276 Pubmed reference(s) in Entrez
CoreMineITGA5
GoPubMedITGA5
iHOPITGA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:12:40 CET 2014
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