Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGA5 (integrin subunit alpha 5)

Identity

Alias_namesalpha polypeptide
FNRA
Alias_symbol (synonym)CD49e
Other aliasVLA-5
VLA5A
HGNC (Hugo) ITGA5
LocusID (NCBI) 3678
Atlas_Id 41006
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 54395261 and ends at 54419266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKNAD1 (1p13.3) / ITGA5 (12q13.13)ITGA5 (12q13.13) / AZI2 (3p24.1)ITGA5 (12q13.13) / GTSF1 (12q13.13)
ITGA5 12q13.13 / GTSF1 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ITGA5/GTSF1 (12q13)

External links

Nomenclature
HGNC (Hugo)ITGA5   6141
Cards
Entrez_Gene (NCBI)ITGA5  3678  integrin subunit alpha 5
AliasesCD49e; FNRA; VLA-5; VLA5A
GeneCards (Weizmann)ITGA5
Ensembl hg19 (Hinxton)ENSG00000161638 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161638 [Gene_View]  ENSG00000161638 [Sequence]  chr12:54395261-54419266 [Contig_View]  ITGA5 [Vega]
ICGC DataPortalENSG00000161638
TCGA cBioPortalITGA5
AceView (NCBI)ITGA5
Genatlas (Paris)ITGA5
WikiGenes3678
SOURCE (Princeton)ITGA5
Genetics Home Reference (NIH)ITGA5
Genomic and cartography
GoldenPath hg38 (UCSC)ITGA5  -     chr12:54395261-54419266 -  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGA5  -     12q13.13   [Description]    (hg19-Feb_2009)
ITGA5 - 12q13.13 [CytoView hg19]  ITGA5 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIITGA5 [Mapview hg19]  ITGA5 [Mapview hg38]
OMIM135620   
Gene and transcription
Genbank (Entrez)AK291570 AK304696 AK311051 AK312414 AU132943
RefSeq transcript (Entrez)NM_002205
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGA5
Cluster EST : UnigeneHs.505654 [ NCBI ]
CGAP (NCI)Hs.505654
Alternative Splicing GalleryENSG00000161638
Gene ExpressionITGA5 [ NCBI-GEO ]   ITGA5 [ EBI - ARRAY_EXPRESS ]   ITGA5 [ SEEK ]   ITGA5 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3678
GTEX Portal (Tissue expression)ITGA5
Human Protein AtlasENSG00000161638-ITGA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08648   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08648  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08648
Splice isoforms : SwissVarP08648
PhosPhoSitePlusP08648
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_alpha_N    Integrin_dom_sf   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
Conserved Domain (NCBI)ITGA5
DMDM Disease mutations3678
Blocks (Seattle)ITGA5
PDB (RSDB)3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
PDB Europe3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
PDB (PDBSum)3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
PDB (IMB)3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
Structural Biology KnowledgeBase3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
SCOP (Structural Classification of Proteins)3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
CATH (Classification of proteins structures)3VI3    3VI4    4WJK    4WK0    4WK2    4WK4   
SuperfamilyP08648
Human Protein Atlas [tissue]ENSG00000161638-ITGA5 [tissue]
Peptide AtlasP08648
HPRD00627
IPIIPI00306604   IPI00910512   IPI01020682   IPI01023060   
Protein Interaction databases
DIP (DOE-UCLA)P08648
IntAct (EBI)P08648
FunCoupENSG00000161638
BioGRIDITGA5
STRING (EMBL)ITGA5
ZODIACITGA5
Ontologies - Pathways
QuickGOP08648
Ontology : AmiGOangiogenesis  virus receptor activity  ruffle  epidermal growth factor receptor binding  platelet-derived growth factor receptor binding  integrin binding  protein binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  cell-cell junction  focal adhesion  focal adhesion  focal adhesion  cell-substrate junction assembly  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  integrin-mediated signaling pathway  female pregnancy  memory  integrin complex  external side of plasma membrane  cell surface  cell surface  positive regulation of cell-substrate adhesion  extracellular matrix organization  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cytoplasmic vesicle  cell-substrate adhesion  ruffle membrane  cell adhesion mediated by integrin  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  wound healing, spreading of epidermal cells  endodermal cell differentiation  vascular endothelial growth factor receptor 2 binding  synapse  viral entry into host cell  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  alphav-beta3 integrin-vitronectin complex  positive regulation of sprouting angiogenesis  negative regulation of anoikis  
Ontology : EGO-EBIangiogenesis  virus receptor activity  ruffle  epidermal growth factor receptor binding  platelet-derived growth factor receptor binding  integrin binding  protein binding  endoplasmic reticulum  Golgi apparatus  plasma membrane  cell-cell junction  focal adhesion  focal adhesion  focal adhesion  cell-substrate junction assembly  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  integrin-mediated signaling pathway  female pregnancy  memory  integrin complex  external side of plasma membrane  cell surface  cell surface  positive regulation of cell-substrate adhesion  extracellular matrix organization  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cytoplasmic vesicle  cell-substrate adhesion  ruffle membrane  cell adhesion mediated by integrin  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  wound healing, spreading of epidermal cells  endodermal cell differentiation  vascular endothelial growth factor receptor 2 binding  synapse  viral entry into host cell  metal ion binding  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  alphav-beta3 integrin-vitronectin complex  positive regulation of sprouting angiogenesis  negative regulation of anoikis  
Pathways : KEGGPhagosome    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Hematopoietic cell lineage    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Shigellosis    Pertussis    Proteoglycans in cancer    MicroRNAs in cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGA5
Atlas of Cancer Signalling NetworkITGA5
Wikipedia pathwaysITGA5
Orthology - Evolution
OrthoDB3678
GeneTree (enSembl)ENSG00000161638
Phylogenetic Trees/Animal Genes : TreeFamITGA5
HOGENOMP08648
Homologs : HomoloGeneITGA5
Homology/Alignments : Family Browser (UCSC)ITGA5
Gene fusions - Rearrangements
Fusion : MitelmanITGA5/GTSF1 [12q13.13/12q13.13]  
Fusion PortalITGA5 12q13.13 GTSF1 12q13.13 LUSC
Fusion : QuiverITGA5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA5
dbVarITGA5
ClinVarITGA5
1000_GenomesITGA5 
Exome Variant ServerITGA5
ExAC (Exome Aggregation Consortium)ENSG00000161638
GNOMAD BrowserENSG00000161638
Varsome BrowserITGA5
Genetic variants : HAPMAP3678
Genomic Variants (DGV)ITGA5 [DGVbeta]
DECIPHERITGA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGA5 
Mutations
ICGC Data PortalITGA5 
TCGA Data PortalITGA5 
Broad Tumor PortalITGA5
OASIS PortalITGA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGA5
DgiDB (Drug Gene Interaction Database)ITGA5
DoCM (Curated mutations)ITGA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGA5 (select a term)
intoGenITGA5
Cancer3DITGA5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135620   
Orphanet
DisGeNETITGA5
MedgenITGA5
Genetic Testing Registry ITGA5
NextProtP08648 [Medical]
TSGene3678
GENETestsITGA5
Target ValidationITGA5
Huge Navigator ITGA5 [HugePedia]
snp3D : Map Gene to Disease3678
BioCentury BCIQITGA5
ClinGenITGA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3678
Chemical/Pharm GKB GenePA29941
Clinical trialITGA5
Miscellaneous
canSAR (ICR)ITGA5 (select the gene name)
DataMed IndexITGA5
Probes
Litterature
PubMed385 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGA5
EVEXITGA5
GoPubMedITGA5
iHOPITGA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu May 2 12:53:52 CEST 2019
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