Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGA8 (integrin subunit alpha 8)

Identity

Alias_namesintegrin, alpha 8
Other alias-
HGNC (Hugo) ITGA8
LocusID (NCBI) 8516
Atlas_Id 41009
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 15513954 and ends at 15719922 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXO18 (10p15.1) / ITGA8 (10p13)ITGA8 (10p13) / ITGA8 (10p13)FBXO18 10p15.1 / ITGA8 10p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGA8   6144
Cards
Entrez_Gene (NCBI)ITGA8  8516  integrin subunit alpha 8
Aliases
GeneCards (Weizmann)ITGA8
Ensembl hg19 (Hinxton)ENSG00000077943 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077943 [Gene_View]  ENSG00000077943 [Sequence]  chr10:15513954-15719922 [Contig_View]  ITGA8 [Vega]
ICGC DataPortalENSG00000077943
TCGA cBioPortalITGA8
AceView (NCBI)ITGA8
Genatlas (Paris)ITGA8
WikiGenes8516
SOURCE (Princeton)ITGA8
Genetics Home Reference (NIH)ITGA8
Genomic and cartography
GoldenPath hg38 (UCSC)ITGA8  -     chr10:15513954-15719922 -  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGA8  -     10p13   [Description]    (hg19-Feb_2009)
GoldenPathITGA8 - 10p13 [CytoView hg19]  ITGA8 - 10p13 [CytoView hg38]
Genome Data Viewer NCBIITGA8 [Mapview hg19]  
OMIM191830   604063   
Gene and transcription
Genbank (Entrez)AK297740 AK308240 BU735798 DB237365 DC425586
RefSeq transcript (Entrez)NM_001291494 NM_003638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGA8
Alternative Splicing GalleryENSG00000077943
Gene ExpressionITGA8 [ NCBI-GEO ]   ITGA8 [ EBI - ARRAY_EXPRESS ]   ITGA8 [ SEEK ]   ITGA8 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGA8 [ Firebrowse - Broad ]
GenevisibleExpression of ITGA8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8516
GTEX Portal (Tissue expression)ITGA8
Human Protein AtlasENSG00000077943-ITGA8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53708   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53708  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53708
Splice isoforms : SwissVarP53708
PhosPhoSitePlusP53708
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_alpha_N    Integrin_dom_sf   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
Conserved Domain (NCBI)ITGA8
DMDM Disease mutations8516
SuperfamilyP53708
Human Protein Atlas [tissue]ENSG00000077943-ITGA8 [tissue]
Peptide AtlasP53708
HPRD10361
IPIIPI00023410   IPI01012103   
Protein Interaction databases
DIP (DOE-UCLA)P53708
IntAct (EBI)P53708
FunCoupENSG00000077943
BioGRIDITGA8
STRING (EMBL)ITGA8
ZODIACITGA8
Ontologies - Pathways
QuickGOP53708
Ontology : AmiGOmetanephros development  kidney development  endoplasmic reticulum  plasma membrane  focal adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  brain development  memory  integrin complex  cell surface  postsynaptic density  cell projection organization  extracellular matrix organization  positive regulation of transforming growth factor beta receptor signaling pathway  dendritic spine membrane  substrate adhesion-dependent cell spreading  integrin alpha8-beta1 complex  inner ear morphogenesis  perikaryon  apical part of cell  establishment of protein localization  metal ion binding  mesodermal cell differentiation  smooth muscle tissue development  cell-cell adhesion  positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  
Ontology : EGO-EBImetanephros development  kidney development  endoplasmic reticulum  plasma membrane  focal adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  brain development  memory  integrin complex  cell surface  postsynaptic density  cell projection organization  extracellular matrix organization  positive regulation of transforming growth factor beta receptor signaling pathway  dendritic spine membrane  substrate adhesion-dependent cell spreading  integrin alpha8-beta1 complex  inner ear morphogenesis  perikaryon  apical part of cell  establishment of protein localization  metal ion binding  mesodermal cell differentiation  smooth muscle tissue development  cell-cell adhesion  positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Cell adhesion molecules (CAMs)    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGA8
Atlas of Cancer Signalling NetworkITGA8
Wikipedia pathwaysITGA8
Orthology - Evolution
OrthoDB8516
GeneTree (enSembl)ENSG00000077943
Phylogenetic Trees/Animal Genes : TreeFamITGA8
HOGENOMP53708
Homologs : HomoloGeneITGA8
Homology/Alignments : Family Browser (UCSC)ITGA8
Gene fusions - Rearrangements
Fusion : MitelmanFBXO18/ITGA8 [10p15.1/10p13]  
Fusion PortalFBXO18 10p15.1 ITGA8 10p13 KIRC
Fusion : QuiverITGA8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGA8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA8
dbVarITGA8
ClinVarITGA8
1000_GenomesITGA8 
Exome Variant ServerITGA8
GNOMAD BrowserENSG00000077943
Varsome BrowserITGA8
Genetic variants : HAPMAP8516
Genomic Variants (DGV)ITGA8 [DGVbeta]
DECIPHERITGA8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGA8 
Mutations
ICGC Data PortalITGA8 
TCGA Data PortalITGA8 
Broad Tumor PortalITGA8
OASIS PortalITGA8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGA8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGA8
Mutations and Diseases : HGMDITGA8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect ITGA8
DgiDB (Drug Gene Interaction Database)ITGA8
DoCM (Curated mutations)ITGA8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGA8 (select a term)
intoGenITGA8
Cancer3DITGA8 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191830    604063   
Orphanet2656   
DisGeNETITGA8
MedgenITGA8
Genetic Testing Registry ITGA8
NextProtP53708 [Medical]
TSGene8516
GENETestsITGA8
Open Targets GeneticsENSG00000077943  [validation]
snp3D : Map Gene to Disease8516
BioCentury BCIQITGA8
ClinGenITGA8
Clinical trials, drugs, therapy
Protein Interactions : CTD8516
Pharm GKB GenePA29944
Clinical trialITGA8
Miscellaneous
canSAR (ICR)ITGA8 (select the gene name)
HarmonizomeITGA8
DataMed IndexITGA8
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGA8
EVEXITGA8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 19:53:53 CEST 2020
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