ITGA8 (integrin subunit alpha 8)

2003-08-01  

Identity

HGNC
LOCATION
10p13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8516
MIM: 604063
HGNC: 6144
Ensembl: ENSG00000077943

Variants:

dbSNP: 8516
ClinVar: 8516
TCGA: ENSG00000077943
COSMIC: ITGA8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077943ENST00000378076P53708

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
195272202009Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.36
155924962005Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.33
247008792014Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.32
193423812009Molecular basis of the recognition of nephronectin by integrin alpha8beta1.30
244391092014Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.20
127874022003Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.15
206784832010Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.15
261980482016ITGA2B and ITGA8 are predictive of prognosis in clear cell renal cell carcinoma patients.13
231423842013Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.10

Citation

Dessen P

ITGA8 (integrin subunit alpha 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41009/itga8