Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGA8 (integrin, alpha 8)

Identity

Other names-
HGNC (Hugo) ITGA8
LocusID (NCBI) 8516
Location 10p13
Location_base_pair Starts at 15555948 and ends at 15762334 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGA8   6144
Cards
Entrez_Gene (NCBI)ITGA8  8516  integrin, alpha 8
GeneCards (Weizmann)ITGA8
Ensembl hg19 (Hinxton) [Gene_View]  chr10:15555948-15762334 [Contig_View]  ITGA8 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr10:15555948-15762334 [Contig_View]  ITGA8 [Vega]
cBioPortalITGA8
AceView (NCBI)ITGA8
Genatlas (Paris)ITGA8
WikiGenes8516
SOURCE (Princeton)ITGA8
Genomic and cartography
GoldenPath hg19 (UCSC)ITGA8  -     chr10:15555948-15762334 -  10p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGA8  -     10p13   [Description]    (hg38-Dec_2013)
EnsemblITGA8 - 10p13 [CytoView hg19]  ITGA8 - 10p13 [CytoView hg38]
Mapping of homologs : NCBIITGA8 [Mapview hg19]  ITGA8 [Mapview hg38]
OMIM191830   604063   
Gene and transcription
Genbank (Entrez)AK297740 AK308240 BC148352 BU735798 DB237365
RefSeq transcript (Entrez)NM_001291494 NM_003638
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_034116 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)ITGA8
Cluster EST : UnigeneHs.592472 [ NCBI ]
CGAP (NCI)Hs.592472
Alternative Splicing : Fast-db (Paris)GSHG0003900
Gene ExpressionITGA8 [ NCBI-GEO ]     ITGA8 [ SEEK ]   ITGA8 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53708 (Uniprot)
NextProtP53708  [Medical]
With graphics : InterProP53708
Splice isoforms : SwissVarP53708 (Swissvar)
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS   
Related proteins : CluSTrP53708
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
DMDM Disease mutations8516
Blocks (Seattle)P53708
Peptide AtlasP53708
HPRD10361
IPIIPI00023410   IPI01012103   
Protein Interaction databases
DIP (DOE-UCLA)P53708
IntAct (EBI)P53708
BioGRIDITGA8
IntegromeDBITGA8
STRING (EMBL)ITGA8
Ontologies - Pathways
QuickGOP53708
Ontology : AmiGOmetanephros development  plasma membrane  cell-matrix adhesion  integrin-mediated signaling pathway  brain development  memory  integrin complex  postsynaptic density  single organismal cell-cell adhesion  cell projection organization  extracellular matrix organization  positive regulation of transforming growth factor beta receptor signaling pathway  dendritic spine membrane  integrin alpha8-beta1 complex  inner ear morphogenesis  perikaryon  apical part of cell  establishment of protein localization  metal ion binding  smooth muscle tissue development  positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  
Ontology : EGO-EBImetanephros development  plasma membrane  cell-matrix adhesion  integrin-mediated signaling pathway  brain development  memory  integrin complex  postsynaptic density  single organismal cell-cell adhesion  cell projection organization  extracellular matrix organization  positive regulation of transforming growth factor beta receptor signaling pathway  dendritic spine membrane  integrin alpha8-beta1 complex  inner ear morphogenesis  perikaryon  apical part of cell  establishment of protein localization  metal ion binding  smooth muscle tissue development  positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Cell adhesion molecules (CAMs)    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
Protein Interaction DatabaseITGA8
DoCM (Curated mutations)ITGA8
Wikipedia pathwaysITGA8
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerITGA8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGA8
dbVarITGA8
ClinVarITGA8
1000_GenomesITGA8 
Exome Variant ServerITGA8
SNP (GeneSNP Utah)ITGA8
SNP : HGBaseITGA8
Genetic variants : HAPMAPITGA8
Genomic VariantsITGA8  ITGA8 [DGVbeta]
Mutations
Somatic Mutations in Cancer : COSMICITGA8 
CONAN: Copy Number AnalysisITGA8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:15555948-15762334
Mutations and Diseases : HGMDITGA8
OMIM191830    604063   
MedgenITGA8
NextProtP53708 [Medical]
GENETestsITGA8
Disease Genetic AssociationITGA8
Huge Navigator ITGA8 [HugePedia]  ITGA8 [HugeCancerGEM]
snp3D : Map Gene to Disease8516
DGIdb (Drug Gene Interaction db)ITGA8
General knowledge
Homologs : HomoloGeneITGA8
Homology/Alignments : Family Browser (UCSC)ITGA8
Phylogenetic Trees/Animal Genes : TreeFamITGA8
Chemical/Protein Interactions : CTD8516
Chemical/Pharm GKB GenePA29944
Clinical trialITGA8
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMineITGA8
GoPubMedITGA8
iHOPITGA8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:12:41 CET 2014
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