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ITGAL (integrin subunit alpha L)

Identity

Alias_namesCD11A
integrin
Alias_symbol (synonym)LFA-1
Other aliasLFA1A
HGNC (Hugo) ITGAL
LocusID (NCBI) 3683
Atlas_Id 41013
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30472662 and ends at 30523185 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ITGAL (16p11.2) / ITGAL (16p11.2)ITGAL (16p11.2) / PSMD8 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGAL   6148
Cards
Entrez_Gene (NCBI)ITGAL  3683  integrin subunit alpha L
AliasesCD11A; LFA-1; LFA1A
GeneCards (Weizmann)ITGAL
Ensembl hg19 (Hinxton)ENSG00000005844 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005844 [Gene_View]  chr16:30472662-30523185 [Contig_View]  ITGAL [Vega]
ICGC DataPortalENSG00000005844
TCGA cBioPortalITGAL
AceView (NCBI)ITGAL
Genatlas (Paris)ITGAL
WikiGenes3683
SOURCE (Princeton)ITGAL
Genetics Home Reference (NIH)ITGAL
Genomic and cartography
GoldenPath hg38 (UCSC)ITGAL  -     chr16:30472662-30523185 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGAL  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblITGAL - 16p11.2 [CytoView hg19]  ITGAL - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIITGAL [Mapview hg19]  ITGAL [Mapview hg38]
OMIM153370   
Gene and transcription
Genbank (Entrez)AK298674 AK303190 AK314246 BC008777 CA430398
RefSeq transcript (Entrez)NM_001114380 NM_002209
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGAL
Cluster EST : UnigeneHs.174103 [ NCBI ]
CGAP (NCI)Hs.174103
Alternative Splicing GalleryENSG00000005844
Gene ExpressionITGAL [ NCBI-GEO ]   ITGAL [ EBI - ARRAY_EXPRESS ]   ITGAL [ SEEK ]   ITGAL [ MEM ]
Gene Expression Viewer (FireBrowse)ITGAL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3683
GTEX Portal (Tissue expression)ITGAL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20701   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20701  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20701
Splice isoforms : SwissVarP20701
PhosPhoSitePlusP20701
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)    VWFA (PS50234)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_dom    VWF_A   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441    pfam00092   
Domain families : Smart (EMBL)Int_alpha (SM00191)  VWA (SM00327)  
Conserved Domain (NCBI)ITGAL
DMDM Disease mutations3683
Blocks (Seattle)ITGAL
PDB (SRS)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
PDB (PDBSum)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
PDB (IMB)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
PDB (RSDB)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
Structural Biology KnowledgeBase1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
SCOP (Structural Classification of Proteins)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
CATH (Classification of proteins structures)1CQP    1DGQ    1IJ4    1LFA    1MJN    1MQ8    1MQ9    1MQA    1RD4    1T0P    1XDD    1XDG    1XUO    1ZON    1ZOO    1ZOP    2ICA    2K8O    2M3E    2O7N    3BN3    3BQM    3BQN    3E2M    3EOA    3EOB    3F74    3F78    3HI6    3M6F    3TCX    4IXD    5E6R    5E6S    5E6U   
SuperfamilyP20701
Human Protein AtlasENSG00000005844
Peptide AtlasP20701
HPRD01079
IPIIPI00025380   IPI00219896   IPI00910027   IPI00909488   IPI00644788   
Protein Interaction databases
DIP (DOE-UCLA)P20701
IntAct (EBI)P20701
FunCoupENSG00000005844
BioGRIDITGAL
STRING (EMBL)ITGAL
ZODIACITGAL
Ontologies - Pathways
QuickGOP20701
Ontology : AmiGOT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  protein binding  plasma membrane  phagocytosis  movement of cell or subcellular component  inflammatory response  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  signal transduction  integrin-mediated signaling pathway  integrin complex  cell surface  membrane  extracellular matrix organization  ICAM-3 receptor activity  protein complex binding  integrin alphaL-beta2 complex  specific granule membrane  receptor clustering  neutrophil degranulation  metal ion binding  protein heterodimerization activity  regulation of immune response  cell adhesion molecule binding  cell adhesion molecule binding  leukocyte migration  extracellular exosome  
Ontology : EGO-EBIT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  protein binding  plasma membrane  phagocytosis  movement of cell or subcellular component  inflammatory response  cell adhesion  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  signal transduction  integrin-mediated signaling pathway  integrin complex  cell surface  membrane  extracellular matrix organization  ICAM-3 receptor activity  protein complex binding  integrin alphaL-beta2 complex  specific granule membrane  receptor clustering  neutrophil degranulation  metal ion binding  protein heterodimerization activity  regulation of immune response  cell adhesion molecule binding  cell adhesion molecule binding  leukocyte migration  extracellular exosome  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkITGAL
Atlas of Cancer Signalling NetworkITGAL
Wikipedia pathwaysITGAL
Orthology - Evolution
OrthoDB3683
GeneTree (enSembl)ENSG00000005844
Phylogenetic Trees/Animal Genes : TreeFamITGAL
HOVERGENP20701
HOGENOMP20701
Homologs : HomoloGeneITGAL
Homology/Alignments : Family Browser (UCSC)ITGAL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGAL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGAL
dbVarITGAL
ClinVarITGAL
1000_GenomesITGAL 
Exome Variant ServerITGAL
ExAC (Exome Aggregation Consortium)ITGAL (select the gene name)
Genetic variants : HAPMAP3683
Genomic Variants (DGV)ITGAL [DGVbeta]
DECIPHERITGAL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGAL 
Mutations
ICGC Data PortalITGAL 
TCGA Data PortalITGAL 
Broad Tumor PortalITGAL
OASIS PortalITGAL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGAL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGAL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGAL
DgiDB (Drug Gene Interaction Database)ITGAL
DoCM (Curated mutations)ITGAL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGAL (select a term)
intoGenITGAL
Cancer3DITGAL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153370   
Orphanet
MedgenITGAL
Genetic Testing Registry ITGAL
NextProtP20701 [Medical]
TSGene3683
GENETestsITGAL
Target ValidationITGAL
Huge Navigator ITGAL [HugePedia]
snp3D : Map Gene to Disease3683
BioCentury BCIQITGAL
ClinGenITGAL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3683
Chemical/Pharm GKB GenePA29948
Clinical trialITGAL
Miscellaneous
canSAR (ICR)ITGAL (select the gene name)
Probes
Litterature
PubMed189 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGAL
EVEXITGAL
GoPubMedITGAL
iHOPITGAL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:38:54 CEST 2017

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