Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ITGAM (integrin subunit alpha M)

Identity

Alias_namesCR3A
CD11B
integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)
integrin, alpha M (complement component 3 receptor 3 subunit)
Alias_symbol (synonym)MAC-1
CD11b
Other aliasMAC1A
MO1A
SLEB6
HGNC (Hugo) ITGAM
LocusID (NCBI) 3684
Atlas_Id 41014
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31259967 and ends at 31332892 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMFR (16q12.2) / ITGAM (16p11.2)ITGAM (16p11.2) / AP1G2 (14q11.2)ITGAM (16p11.2) / ITGAM (16p11.2)
AMFR 16q12.2 / ITGAM 16p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGAM   6149
Cards
Entrez_Gene (NCBI)ITGAM  3684  integrin subunit alpha M
AliasesCD11B; CR3A; MAC-1; MAC1A; 
MO1A; SLEB6
GeneCards (Weizmann)ITGAM
Ensembl hg19 (Hinxton)ENSG00000169896 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169896 [Gene_View]  chr16:31259967-31332892 [Contig_View]  ITGAM [Vega]
ICGC DataPortalENSG00000169896
TCGA cBioPortalITGAM
AceView (NCBI)ITGAM
Genatlas (Paris)ITGAM
WikiGenes3684
SOURCE (Princeton)ITGAM
Genetics Home Reference (NIH)ITGAM
Genomic and cartography
GoldenPath hg38 (UCSC)ITGAM  -     chr16:31259967-31332892 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGAM  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblITGAM - 16p11.2 [CytoView hg19]  ITGAM - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIITGAM [Mapview hg19]  ITGAM [Mapview hg38]
OMIM120980   609939   
Gene and transcription
Genbank (Entrez)AA436312 AK057856 AK127637 AY187247 AY187248
RefSeq transcript (Entrez)NM_000632 NM_001145808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGAM
Cluster EST : UnigeneHs.172631 [ NCBI ]
CGAP (NCI)Hs.172631
Alternative Splicing GalleryENSG00000169896
Gene ExpressionITGAM [ NCBI-GEO ]   ITGAM [ EBI - ARRAY_EXPRESS ]   ITGAM [ SEEK ]   ITGAM [ MEM ]
Gene Expression Viewer (FireBrowse)ITGAM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3684
GTEX Portal (Tissue expression)ITGAM
Human Protein AtlasENSG00000169896-ITGAM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11215   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11215  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11215
Splice isoforms : SwissVarP11215
PhosPhoSitePlusP11215
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)    VWFA (PS50234)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_dom    VWF_A   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441    pfam00092   
Domain families : Smart (EMBL)Int_alpha (SM00191)  VWA (SM00327)  
Conserved Domain (NCBI)ITGAM
DMDM Disease mutations3684
Blocks (Seattle)ITGAM
PDB (SRS)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
PDB (PDBSum)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
PDB (IMB)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
PDB (RSDB)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
Structural Biology KnowledgeBase1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
SCOP (Structural Classification of Proteins)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
CATH (Classification of proteins structures)1A8X    1BHO    1BHQ    1IDN    1IDO    1JLM    1M1U    1MF7    1N9Z    1NA5    2LKE    2LKJ    3Q3G    3QA3    4M76    4XW2   
SuperfamilyP11215
Human Protein Atlas [tissue]ENSG00000169896-ITGAM [tissue]
Peptide AtlasP11215
HPRD00411
IPIIPI00217987   IPI00645887   
Protein Interaction databases
DIP (DOE-UCLA)P11215
IntAct (EBI)P11215
FunCoupENSG00000169896
BioGRIDITGAM
STRING (EMBL)ITGAM
ZODIACITGAM
Ontologies - Pathways
QuickGOP11215
Ontology : AmiGOglycoprotein binding  protein binding  extracellular space  plasma membrane  cell adhesion  integrin-mediated signaling pathway  integrin complex  cell surface  ectodermal cell differentiation  extracellular matrix organization  heat shock protein binding  toll-like receptor 4 signaling pathway  specific granule membrane  neutrophil degranulation  metal ion binding  protein heterodimerization activity  leukocyte migration  extracellular exosome  tertiary granule membrane  
Ontology : EGO-EBIglycoprotein binding  protein binding  extracellular space  plasma membrane  cell adhesion  integrin-mediated signaling pathway  integrin complex  cell surface  ectodermal cell differentiation  extracellular matrix organization  heat shock protein binding  toll-like receptor 4 signaling pathway  specific granule membrane  neutrophil degranulation  metal ion binding  protein heterodimerization activity  leukocyte migration  extracellular exosome  tertiary granule membrane  
Pathways : BIOCARTAAdhesion and Diapedesis of Granulocytes [Genes]    Neutrophil and Its Surface Molecules [Genes]    Monocyte and its Surface Molecules [Genes]   
Pathways : KEGG   
NDEx NetworkITGAM
Atlas of Cancer Signalling NetworkITGAM
Wikipedia pathwaysITGAM
Orthology - Evolution
OrthoDB3684
GeneTree (enSembl)ENSG00000169896
Phylogenetic Trees/Animal Genes : TreeFamITGAM
HOVERGENP11215
HOGENOMP11215
Homologs : HomoloGeneITGAM
Homology/Alignments : Family Browser (UCSC)ITGAM
Gene fusions - Rearrangements
Fusion : MitelmanAMFR/ITGAM [16q12.2/16p11.2]  [t(16;16)(p11;q12)]  
Fusion: TCGA_MDACCAMFR 16q12.2 ITGAM 16p11.2 BRCA
Tumor Fusion PortalITGAM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGAM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGAM
dbVarITGAM
ClinVarITGAM
1000_GenomesITGAM 
Exome Variant ServerITGAM
ExAC (Exome Aggregation Consortium)ENSG00000169896
GNOMAD BrowserENSG00000169896
Genetic variants : HAPMAP3684
Genomic Variants (DGV)ITGAM [DGVbeta]
DECIPHERITGAM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGAM 
Mutations
ICGC Data PortalITGAM 
TCGA Data PortalITGAM 
Broad Tumor PortalITGAM
OASIS PortalITGAM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGAM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGAM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGAM
DgiDB (Drug Gene Interaction Database)ITGAM
DoCM (Curated mutations)ITGAM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGAM (select a term)
intoGenITGAM
Cancer3DITGAM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120980    609939   
Orphanet
DisGeNETITGAM
MedgenITGAM
Genetic Testing Registry ITGAM
NextProtP11215 [Medical]
TSGene3684
GENETestsITGAM
Target ValidationITGAM
Huge Navigator ITGAM [HugePedia]
snp3D : Map Gene to Disease3684
BioCentury BCIQITGAM
ClinGenITGAM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3684
Chemical/Pharm GKB GenePA29949
Clinical trialITGAM
Miscellaneous
canSAR (ICR)ITGAM (select the gene name)
Probes
Litterature
PubMed275 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGAM
EVEXITGAM
GoPubMedITGAM
iHOPITGAM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:13 CET 2017

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