Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGAX (integrin subunit alpha X)

Identity

Alias (NCBI)CD11C
SLEB6
HGNC (Hugo) ITGAX
HGNC Alias symbCD11c
HGNC Alias namecomplement component 3 receptor 4 subunit
HGNC Previous nameCD11C
HGNC Previous nameintegrin, alpha X (antigen CD11C (p150), alpha polypeptide)
 integrin, alpha X (complement component 3 receptor 4 subunit)
LocusID (NCBI) 3687
Atlas_Id 41016
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31355176 and ends at 31382999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGAX (16p11.2) / PHKG2 (16p11.2)LRRC25 (19p13.11) / ITGAX (16p11.2)TG (8q24.22) / ITGAX (16p11.2)
ITGAX 16p11.2 / PHKG2 16p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ITGAX/PHKG2 (16p11)

External links

Nomenclature
HGNC (Hugo)ITGAX   6152
Cards
Entrez_Gene (NCBI)ITGAX  3687  integrin subunit alpha X
AliasesCD11C; SLEB6
GeneCards (Weizmann)ITGAX
Ensembl hg19 (Hinxton)ENSG00000140678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140678 [Gene_View]  ENSG00000140678 [Sequence]  chr16:31355176-31382999 [Contig_View]  ITGAX [Vega]
ICGC DataPortalENSG00000140678
TCGA cBioPortalITGAX
AceView (NCBI)ITGAX
Genatlas (Paris)ITGAX
WikiGenes3687
SOURCE (Princeton)ITGAX
Genetics Home Reference (NIH)ITGAX
Genomic and cartography
GoldenPath hg38 (UCSC)ITGAX  -     chr16:31355176-31382999 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGAX  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathITGAX - 16p11.2 [CytoView hg19]  ITGAX - 16p11.2 [CytoView hg38]
ImmunoBaseENSG00000140678
genome Data Viewer NCBIITGAX [Mapview hg19]  
OMIM151510   
Gene and transcription
Genbank (Entrez)AK074047 AK293367 AK296666 AK309642 AW014280
RefSeq transcript (Entrez)NM_000887 NM_001286375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGAX
Alternative Splicing GalleryENSG00000140678
Gene ExpressionITGAX [ NCBI-GEO ]   ITGAX [ EBI - ARRAY_EXPRESS ]   ITGAX [ SEEK ]   ITGAX [ MEM ]
Gene Expression Viewer (FireBrowse)ITGAX [ Firebrowse - Broad ]
GenevisibleExpression of ITGAX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3687
GTEX Portal (Tissue expression)ITGAX
Human Protein AtlasENSG00000140678-ITGAX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20702   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20702  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20702
Splice isoforms : SwissVarP20702
PhosPhoSitePlusP20702
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)    VWFA (PS50234)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_alpha_N    Integrin_dom_sf    VWF_A    vWFA_dom_sf   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441    pfam00092   
Domain families : Smart (EMBL)Int_alpha (SM00191)  VWA (SM00327)  
Conserved Domain (NCBI)ITGAX
DMDM Disease mutations3687
Blocks (Seattle)ITGAX
PDB (RSDB)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB Europe1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB (PDBSum)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB (IMB)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
Structural Biology KnowledgeBase1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
SCOP (Structural Classification of Proteins)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
CATH (Classification of proteins structures)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
SuperfamilyP20702
Human Protein Atlas [tissue]ENSG00000140678-ITGAX [tissue]
Peptide AtlasP20702
HPRD01051
IPIIPI00910199   IPI00641386   IPI00479724   
Protein Interaction databases
DIP (DOE-UCLA)P20702
IntAct (EBI)P20702
FunCoupENSG00000140678
BioGRIDITGAX
STRING (EMBL)ITGAX
ZODIACITGAX
Ontologies - Pathways
QuickGOP20702
Ontology : AmiGOintegrin binding  protein binding  plasma membrane  cell adhesion  integrin-mediated signaling pathway  positive regulation of cell proliferation  integrin complex  animal organ morphogenesis  cell surface  cell surface  cell surface  positive regulation of gene expression  positive regulation of gene expression  membrane  cytokine-mediated signaling pathway  extracellular matrix organization  positive regulation of cell migration  secretory granule membrane  receptor tyrosine kinase binding  positive regulation of myelination  heterotypic cell-cell adhesion  integrin alphaX-beta2 complex  signaling receptor activity  neutrophil degranulation  positive regulation of angiogenesis  metal ion binding  leukocyte migration  tertiary granule membrane  ficolin-1-rich granule membrane  positive regulation of endothelial tube morphogenesis  
Ontology : EGO-EBIintegrin binding  protein binding  plasma membrane  cell adhesion  integrin-mediated signaling pathway  positive regulation of cell proliferation  integrin complex  animal organ morphogenesis  cell surface  cell surface  cell surface  positive regulation of gene expression  positive regulation of gene expression  membrane  cytokine-mediated signaling pathway  extracellular matrix organization  positive regulation of cell migration  secretory granule membrane  receptor tyrosine kinase binding  positive regulation of myelination  heterotypic cell-cell adhesion  integrin alphaX-beta2 complex  signaling receptor activity  neutrophil degranulation  positive regulation of angiogenesis  metal ion binding  leukocyte migration  tertiary granule membrane  ficolin-1-rich granule membrane  positive regulation of endothelial tube morphogenesis  
Pathways : KEGGRegulation of actin cytoskeleton    Tuberculosis   
NDEx NetworkITGAX
Atlas of Cancer Signalling NetworkITGAX
Wikipedia pathwaysITGAX
Orthology - Evolution
OrthoDB3687
GeneTree (enSembl)ENSG00000140678
Phylogenetic Trees/Animal Genes : TreeFamITGAX
HOGENOMP20702
Homologs : HomoloGeneITGAX
Homology/Alignments : Family Browser (UCSC)ITGAX
Gene fusions - Rearrangements
Fusion : MitelmanITGAX/PHKG2 [16p11.2/16p11.2]  
Fusion PortalITGAX 16p11.2 PHKG2 16p11.2 BLCA
Fusion : QuiverITGAX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGAX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGAX
dbVarITGAX
ClinVarITGAX
1000_GenomesITGAX 
Exome Variant ServerITGAX
GNOMAD BrowserENSG00000140678
Varsome BrowserITGAX
Genetic variants : HAPMAP3687
Genomic Variants (DGV)ITGAX [DGVbeta]
DECIPHERITGAX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGAX 
Mutations
ICGC Data PortalITGAX 
TCGA Data PortalITGAX 
Broad Tumor PortalITGAX
OASIS PortalITGAX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGAX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGAX
Mutations and Diseases : HGMDITGAX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGAX
DgiDB (Drug Gene Interaction Database)ITGAX
DoCM (Curated mutations)ITGAX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGAX (select a term)
intoGenITGAX
Cancer3DITGAX(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151510   
Orphanet
DisGeNETITGAX
MedgenITGAX
Genetic Testing Registry ITGAX
NextProtP20702 [Medical]
TSGene3687
GENETestsITGAX
Target ValidationITGAX
Huge Navigator ITGAX [HugePedia]
snp3D : Map Gene to Disease3687
BioCentury BCIQITGAX
ClinGenITGAX
Clinical trials, drugs, therapy
Protein Interactions : CTD3687
Pharm GKB GenePA29952
Clinical trialITGAX
Miscellaneous
canSAR (ICR)ITGAX (select the gene name)
HarmonizomeITGAX
DataMed IndexITGAX
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGAX
EVEXITGAX
GoPubMedITGAX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:18:33 CEST 2020
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