Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGAX (integrin subunit alpha X)

Identity

Alias_namesCD11C
integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
integrin, alpha X (complement component 3 receptor 4 subunit)
Alias_symbol (synonym)CD11c
Other aliasSLEB6
HGNC (Hugo) ITGAX
LocusID (NCBI) 3687
Atlas_Id 41016
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31355134 and ends at 31382997 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGAX (16p11.2) / PHKG2 (16p11.2)LRRC25 (19p13.11) / ITGAX (16p11.2)TG (8q24.22) / ITGAX (16p11.2)
ITGAX 16p11.2 / PHKG2 16p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(p11;p11) ITGAX/PHKG2

External links

Nomenclature
HGNC (Hugo)ITGAX   6152
Cards
Entrez_Gene (NCBI)ITGAX  3687  integrin subunit alpha X
AliasesCD11C; SLEB6
GeneCards (Weizmann)ITGAX
Ensembl hg19 (Hinxton)ENSG00000140678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140678 [Gene_View]  ENSG00000140678 [Sequence]  chr16:31355134-31382997 [Contig_View]  ITGAX [Vega]
ICGC DataPortalENSG00000140678
TCGA cBioPortalITGAX
AceView (NCBI)ITGAX
Genatlas (Paris)ITGAX
WikiGenes3687
SOURCE (Princeton)ITGAX
Genetics Home Reference (NIH)ITGAX
Genomic and cartography
GoldenPath hg38 (UCSC)ITGAX  -     chr16:31355134-31382997 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGAX  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblITGAX - 16p11.2 [CytoView hg19]  ITGAX - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIITGAX [Mapview hg19]  ITGAX [Mapview hg38]
OMIM151510   
Gene and transcription
Genbank (Entrez)AK074047 AK293367 AK296666 AK309642 AW014280
RefSeq transcript (Entrez)NM_000887 NM_001286375
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGAX
Cluster EST : UnigeneHs.248472 [ NCBI ]
CGAP (NCI)Hs.248472
Alternative Splicing GalleryENSG00000140678
Gene ExpressionITGAX [ NCBI-GEO ]   ITGAX [ EBI - ARRAY_EXPRESS ]   ITGAX [ SEEK ]   ITGAX [ MEM ]
Gene Expression Viewer (FireBrowse)ITGAX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3687
GTEX Portal (Tissue expression)ITGAX
Human Protein AtlasENSG00000140678-ITGAX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20702   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20702  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20702
Splice isoforms : SwissVarP20702
PhosPhoSitePlusP20702
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)    INTEGRIN_ALPHA (PS00242)    VWFA (PS50234)   
Domains : Interpro (EBI)FG-GAP    Int_alpha_beta-p    Integrin_alpha    Integrin_alpha-2    Integrin_alpha_C_CS    Integrin_dom    VWF_A   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Integrin_alpha (PF00357)    Integrin_alpha2 (PF08441)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam01839    pfam00357    pfam08441    pfam00092   
Domain families : Smart (EMBL)Int_alpha (SM00191)  VWA (SM00327)  
Conserved Domain (NCBI)ITGAX
DMDM Disease mutations3687
Blocks (Seattle)ITGAX
PDB (SRS)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB (PDBSum)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB (IMB)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
PDB (RSDB)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
Structural Biology KnowledgeBase1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
SCOP (Structural Classification of Proteins)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
CATH (Classification of proteins structures)1N3Y    2LUV    3K6S    3K71    3K72    4NEH    4NEN    5ES4   
SuperfamilyP20702
Human Protein Atlas [tissue]ENSG00000140678-ITGAX [tissue]
Peptide AtlasP20702
HPRD01051
IPIIPI00910199   IPI00641386   IPI00479724   
Protein Interaction databases
DIP (DOE-UCLA)P20702
IntAct (EBI)P20702
FunCoupENSG00000140678
BioGRIDITGAX
STRING (EMBL)ITGAX
ZODIACITGAX
Ontologies - Pathways
QuickGOP20702
Ontology : AmiGOreceptor activity  protein binding  plasma membrane  cell adhesion  integrin-mediated signaling pathway  integrin complex  animal organ morphogenesis  cell surface  cell surface  cell surface  membrane  cytokine-mediated signaling pathway  extracellular matrix organization  secretory granule membrane  heterotypic cell-cell adhesion  neutrophil degranulation  metal ion binding  leukocyte migration  tertiary granule membrane  ficolin-1-rich granule membrane  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIreceptor activity  protein binding  plasma membrane  cell adhesion  integrin-mediated signaling pathway  integrin complex  animal organ morphogenesis  cell surface  cell surface  cell surface  membrane  cytokine-mediated signaling pathway  extracellular matrix organization  secretory granule membrane  heterotypic cell-cell adhesion  neutrophil degranulation  metal ion binding  leukocyte migration  tertiary granule membrane  ficolin-1-rich granule membrane  positive regulation of protein targeting to mitochondrion  
Pathways : BIOCARTADendritic cells in regulating TH1 and TH2 Development [Genes]   
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkITGAX
Atlas of Cancer Signalling NetworkITGAX
Wikipedia pathwaysITGAX
Orthology - Evolution
OrthoDB3687
GeneTree (enSembl)ENSG00000140678
Phylogenetic Trees/Animal Genes : TreeFamITGAX
HOVERGENP20702
HOGENOMP20702
Homologs : HomoloGeneITGAX
Homology/Alignments : Family Browser (UCSC)ITGAX
Gene fusions - Rearrangements
Fusion : MitelmanITGAX/PHKG2 [16p11.2/16p11.2]  
Fusion PortalITGAX 16p11.2 PHKG2 16p11.2 BLCA
Fusion : QuiverITGAX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGAX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGAX
dbVarITGAX
ClinVarITGAX
1000_GenomesITGAX 
Exome Variant ServerITGAX
ExAC (Exome Aggregation Consortium)ENSG00000140678
GNOMAD BrowserENSG00000140678
Genetic variants : HAPMAP3687
Genomic Variants (DGV)ITGAX [DGVbeta]
DECIPHERITGAX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGAX 
Mutations
ICGC Data PortalITGAX 
TCGA Data PortalITGAX 
Broad Tumor PortalITGAX
OASIS PortalITGAX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGAX  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGAX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGAX
DgiDB (Drug Gene Interaction Database)ITGAX
DoCM (Curated mutations)ITGAX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGAX (select a term)
intoGenITGAX
Cancer3DITGAX(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151510   
Orphanet
DisGeNETITGAX
MedgenITGAX
Genetic Testing Registry ITGAX
NextProtP20702 [Medical]
TSGene3687
GENETestsITGAX
Target ValidationITGAX
Huge Navigator ITGAX [HugePedia]
snp3D : Map Gene to Disease3687
BioCentury BCIQITGAX
ClinGenITGAX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3687
Chemical/Pharm GKB GenePA29952
Clinical trialITGAX
Miscellaneous
canSAR (ICR)ITGAX (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGAX
EVEXITGAX
GoPubMedITGAX
iHOPITGAX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:31:22 CEST 2018
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