Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGB1 (integrin subunit beta 1)

Identity

Alias_namesFNRB
MSK12
MDF2
integrin
Alias_symbol (synonym)CD29
GPIIA
Other aliasVLA-BETA
VLAB
HGNC (Hugo) ITGB1
LocusID (NCBI) 3688
Atlas_Id 41017
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 32900318 and ends at 32957894 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPZB (1p36.13) / ITGB1 (10p11.22)CCDC117 (22q12.1) / ITGB1 (10p11.22)ITGB1 (10p11.22) / ITGB1 (10p11.22)
ITGB1 (10p11.22) / MYL9 (20q11.23)ITGB1 (10p11.22) / ZNF717 (3p12.3)NRP1 (10p11.22) / ITGB1 (10p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGB1   6153
Cards
Entrez_Gene (NCBI)ITGB1  3688  integrin subunit beta 1
AliasesCD29; FNRB; GPIIA; MDF2; 
MSK12; VLA-BETA; VLAB
GeneCards (Weizmann)ITGB1
Ensembl hg19 (Hinxton)ENSG00000150093 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150093 [Gene_View]  ENSG00000150093 [Sequence]  chr10:32900318-32957894 [Contig_View]  ITGB1 [Vega]
ICGC DataPortalENSG00000150093
TCGA cBioPortalITGB1
AceView (NCBI)ITGB1
Genatlas (Paris)ITGB1
WikiGenes3688
SOURCE (Princeton)ITGB1
Genetics Home Reference (NIH)ITGB1
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB1  -     chr10:32900318-32957894 -  10p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB1  -     10p11.22   [Description]    (hg19-Feb_2009)
EnsemblITGB1 - 10p11.22 [CytoView hg19]  ITGB1 - 10p11.22 [CytoView hg38]
Mapping of homologs : NCBIITGB1 [Mapview hg19]  ITGB1 [Mapview hg38]
OMIM135630   
Gene and transcription
Genbank (Entrez)AI261443 AK291697 AL710802 BC020057 BC113901
RefSeq transcript (Entrez)NM_002211 NM_033666 NM_033667 NM_033668 NM_033669 NM_133376
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGB1
Cluster EST : UnigeneHs.643813 [ NCBI ]
CGAP (NCI)Hs.643813
Alternative Splicing GalleryENSG00000150093
Gene ExpressionITGB1 [ NCBI-GEO ]   ITGB1 [ EBI - ARRAY_EXPRESS ]   ITGB1 [ SEEK ]   ITGB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3688
GTEX Portal (Tissue expression)ITGB1
Human Protein AtlasENSG00000150093-ITGB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05556   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05556  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05556
Splice isoforms : SwissVarP05556
PhosPhoSitePlusP05556
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integin_beta_N    Integrin_beta-1    Integrin_bsu    Integrin_bsu_cyt_dom    Integrin_bsu_tail    Integrin_bsu_VWA    Integrin_dom    PSI    VWF_A   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)INB (SM00187)  Integrin_b_cyt (SM01241)  Integrin_B_tail (SM01242)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB1
DMDM Disease mutations3688
Blocks (Seattle)ITGB1
PDB (SRS)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (PDBSum)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (IMB)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (RSDB)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
Structural Biology KnowledgeBase1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
SCOP (Structural Classification of Proteins)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
CATH (Classification of proteins structures)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
SuperfamilyP05556
Human Protein Atlas [tissue]ENSG00000150093-ITGB1 [tissue]
Peptide AtlasP05556
HPRD00628
IPIIPI00217563   IPI00293305   IPI00217561   IPI00217562   IPI00549336   IPI00971091   IPI00978405   IPI00979111   IPI00945878   IPI00945037   IPI00947385   IPI00945168   IPI00946209   IPI00642219   IPI01015358   IPI01013133   
Protein Interaction databases
DIP (DOE-UCLA)P05556
IntAct (EBI)P05556
FunCoupENSG00000150093
BioGRIDITGB1
STRING (EMBL)ITGB1
ZODIACITGB1
Ontologies - Pathways
QuickGOP05556
Ontology : AmiGOG1/S transition of mitotic cell cycle  virus receptor activity  in utero embryonic development  cell fate specification  ruffle  fibronectin binding  protease binding  cell migration involved in sprouting angiogenesis  actin binding  integrin binding  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  focal adhesion  focal adhesion  focal adhesion  cellular defense response  homophilic cell adhesion via plasma membrane adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  calcium-independent cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  positive regulation of cell proliferation  integrin complex  germ cell migration  visual learning  external side of plasma membrane  cell surface  cell surface  regulation of collagen catabolic process  intercalated disc  coreceptor activity  membrane  cell migration  cytokine-mediated signaling pathway  C-X3-C chemokine binding  formation of radial glial scaffolds  lamellipodium  filopodium  B cell differentiation  extracellular matrix organization  cell-substrate adhesion  neuromuscular junction  receptor internalization  cleavage furrow  protein complex binding  ruffle membrane  ruffle membrane  cell adhesion mediated by integrin  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  integrin alpha1-beta1 complex  integrin alpha2-beta1 complex  integrin alpha3-beta1 complex  integrin alpha7-beta1 complex  integrin alpha8-beta1 complex  integrin alpha10-beta1 complex  integrin alpha11-beta1 complex  negative regulation of Rho protein signal transduction  myelin sheath abaxonal region  sarcolemma  melanosome  positive regulation of apoptotic process  stress fiber assembly  dendritic spine  receptor complex  laminin binding  positive regulation of GTPase activity  membrane raft  sarcomere organization  cadherin binding  negative regulation of cell differentiation  positive regulation of angiogenesis  viral entry into host cell  metal ion binding  protein heterodimerization activity  protein heterodimerization activity  mesodermal cell differentiation  perinuclear region of cytoplasm  axon extension  dendrite morphogenesis  regulation of immune response  cell adhesion molecule binding  leukocyte migration  leukocyte tethering or rolling  regulation of cell cycle  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  recycling endosome  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  invadopodium membrane  basement membrane organization  synaptic membrane  collagen binding involved in cell-matrix adhesion  positive regulation of protein localization to plasma membrane  positive regulation of receptor activity  negative regulation of anoikis  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  virus receptor activity  in utero embryonic development  cell fate specification  ruffle  fibronectin binding  protease binding  cell migration involved in sprouting angiogenesis  actin binding  integrin binding  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  focal adhesion  focal adhesion  focal adhesion  cellular defense response  homophilic cell adhesion via plasma membrane adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  calcium-independent cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  positive regulation of cell proliferation  integrin complex  germ cell migration  visual learning  external side of plasma membrane  cell surface  cell surface  regulation of collagen catabolic process  intercalated disc  coreceptor activity  membrane  cell migration  cytokine-mediated signaling pathway  C-X3-C chemokine binding  formation of radial glial scaffolds  lamellipodium  filopodium  B cell differentiation  extracellular matrix organization  cell-substrate adhesion  neuromuscular junction  receptor internalization  cleavage furrow  protein complex binding  ruffle membrane  ruffle membrane  cell adhesion mediated by integrin  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  integrin alpha1-beta1 complex  integrin alpha2-beta1 complex  integrin alpha3-beta1 complex  integrin alpha7-beta1 complex  integrin alpha8-beta1 complex  integrin alpha10-beta1 complex  integrin alpha11-beta1 complex  negative regulation of Rho protein signal transduction  myelin sheath abaxonal region  sarcolemma  melanosome  positive regulation of apoptotic process  stress fiber assembly  dendritic spine  receptor complex  laminin binding  positive regulation of GTPase activity  membrane raft  sarcomere organization  cadherin binding  negative regulation of cell differentiation  positive regulation of angiogenesis  viral entry into host cell  metal ion binding  protein heterodimerization activity  protein heterodimerization activity  mesodermal cell differentiation  perinuclear region of cytoplasm  axon extension  dendrite morphogenesis  regulation of immune response  cell adhesion molecule binding  leukocyte migration  leukocyte tethering or rolling  regulation of cell cycle  positive regulation of protein kinase B signaling  cardiac muscle cell differentiation  recycling endosome  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  invadopodium membrane  basement membrane organization  synaptic membrane  collagen binding involved in cell-matrix adhesion  positive regulation of protein localization to plasma membrane  positive regulation of receptor activity  negative regulation of anoikis  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    mCalpain and friends in Cell motility [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Cells and Molecules involved in local acute inflammatory response [Genes]    B Cell Survival Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    uCalpain and friends in Cell spread [Genes]    Monocyte and its Surface Molecules [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Eph Kinases and ephrins support platelet aggregation [Genes]    Integrin Signaling Pathway [Genes]    Adhesion Molecules on Lymphocyte [Genes]   
Pathways : KEGGECM-receptor interaction    Regulation of actin cytoskeleton    Leukocyte transendothelial migration    Cell adhesion molecules (CAMs)    Focal adhesion    Axon guidance   
NDEx NetworkITGB1
Atlas of Cancer Signalling NetworkITGB1
Wikipedia pathwaysITGB1
Orthology - Evolution
OrthoDB3688
GeneTree (enSembl)ENSG00000150093
Phylogenetic Trees/Animal Genes : TreeFamITGB1
HOVERGENP05556
HOGENOMP05556
Homologs : HomoloGeneITGB1
Homology/Alignments : Family Browser (UCSC)ITGB1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)ITGB1 [10p11.22]  -  ZNF717 [3p12.3]  [FUSC002864]
Fusion : QuiverITGB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB1
dbVarITGB1
ClinVarITGB1
1000_GenomesITGB1 
Exome Variant ServerITGB1
ExAC (Exome Aggregation Consortium)ENSG00000150093
GNOMAD BrowserENSG00000150093
Genetic variants : HAPMAP3688
Genomic Variants (DGV)ITGB1 [DGVbeta]
DECIPHERITGB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB1 
Mutations
ICGC Data PortalITGB1 
TCGA Data PortalITGB1 
Broad Tumor PortalITGB1
OASIS PortalITGB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB1
DgiDB (Drug Gene Interaction Database)ITGB1
DoCM (Curated mutations)ITGB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB1 (select a term)
intoGenITGB1
Cancer3DITGB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135630   
Orphanet
DisGeNETITGB1
MedgenITGB1
Genetic Testing Registry ITGB1
NextProtP05556 [Medical]
TSGene3688
GENETestsITGB1
Target ValidationITGB1
Huge Navigator ITGB1 [HugePedia]
snp3D : Map Gene to Disease3688
BioCentury BCIQITGB1
ClinGenITGB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3688
Chemical/Pharm GKB GenePA29953
Clinical trialITGB1
Miscellaneous
canSAR (ICR)ITGB1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB1
EVEXITGB1
GoPubMedITGB1
iHOPITGB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:31:22 CEST 2018
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