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ITGB1 (integrin subunit beta 1)

Identity

Alias_namesFNRB
MSK12
MDF2
integrin
Alias_symbol (synonym)CD29
GPIIA
Other aliasVLA-BETA
VLAB
HGNC (Hugo) ITGB1
LocusID (NCBI) 3688
Atlas_Id 41017
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 33189246 and ends at 33247293 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAPZB (1p36.13) / ITGB1 (10p11.22)CCDC117 (22q12.1) / ITGB1 (10p11.22)ITGB1 (10p11.22) / ITGB1 (10p11.22)
ITGB1 (10p11.22) / MYL9 (20q11.23)ITGB1 (10p11.22) / ZNF717 (3p12.3)NRP1 (10p11.22) / ITGB1 (10p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGB1   6153
Cards
Entrez_Gene (NCBI)ITGB1  3688  integrin subunit beta 1
AliasesCD29; FNRB; GPIIA; MDF2; 
MSK12; VLA-BETA; VLAB
GeneCards (Weizmann)ITGB1
Ensembl hg19 (Hinxton)ENSG00000150093 [Gene_View]  chr10:33189246-33247293 [Contig_View]  ITGB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000150093 [Gene_View]  chr10:33189246-33247293 [Contig_View]  ITGB1 [Vega]
ICGC DataPortalENSG00000150093
TCGA cBioPortalITGB1
AceView (NCBI)ITGB1
Genatlas (Paris)ITGB1
WikiGenes3688
SOURCE (Princeton)ITGB1
Genetics Home Reference (NIH)ITGB1
Genomic and cartography
GoldenPath hg19 (UCSC)ITGB1  -     chr10:33189246-33247293 -  10p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGB1  -     10p11.22   [Description]    (hg38-Dec_2013)
EnsemblITGB1 - 10p11.22 [CytoView hg19]  ITGB1 - 10p11.22 [CytoView hg38]
Mapping of homologs : NCBIITGB1 [Mapview hg19]  ITGB1 [Mapview hg38]
OMIM135630   
Gene and transcription
Genbank (Entrez)AI261443 AK291697 AL710802 AM393197 BC020057
RefSeq transcript (Entrez)NM_002211 NM_033666 NM_033667 NM_033668 NM_033669 NM_133376
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_029012 NT_008705 NW_004929370
Consensus coding sequences : CCDS (NCBI)ITGB1
Cluster EST : UnigeneHs.643813 [ NCBI ]
CGAP (NCI)Hs.643813
Alternative Splicing GalleryENSG00000150093
Gene ExpressionITGB1 [ NCBI-GEO ]   ITGB1 [ EBI - ARRAY_EXPRESS ]   ITGB1 [ SEEK ]   ITGB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3688
GTEX Portal (Tissue expression)ITGB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05556   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05556  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05556
Splice isoforms : SwissVarP05556
PhosPhoSitePlusP05556
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integrin_beta-1    Integrin_bsu    Integrin_bsu_cyt_dom    Integrin_bsu_N    Integrin_bsu_tail    Integrin_dom    Plexin-like_fold    VWF_A   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam07965    pfam00362   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
Conserved Domain (NCBI)ITGB1
DMDM Disease mutations3688
Blocks (Seattle)ITGB1
PDB (SRS)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (PDBSum)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (IMB)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
PDB (RSDB)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
Structural Biology KnowledgeBase1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
SCOP (Structural Classification of Proteins)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
CATH (Classification of proteins structures)1K11    1LHA    3G9W    3T9K    3VI3    3VI4    4DX9    4WJK    4WK0    4WK2    4WK4   
SuperfamilyP05556
Human Protein AtlasENSG00000150093
Peptide AtlasP05556
HPRD00628
IPIIPI00217563   IPI00293305   IPI00217561   IPI00217562   IPI00549336   IPI00971091   IPI00978405   IPI00979111   IPI00945878   IPI00945037   IPI00947385   IPI00945168   IPI00946209   IPI00642219   IPI01015358   IPI01013133   
Protein Interaction databases
DIP (DOE-UCLA)P05556
IntAct (EBI)P05556
FunCoupENSG00000150093
BioGRIDITGB1
STRING (EMBL)ITGB1
ZODIACITGB1
Ontologies - Pathways
QuickGOP05556
Ontology : AmiGOG1/S transition of mitotic cell cycle  virus receptor activity  acrosomal vesicle  in utero embryonic development  cell fate specification  ruffle  tissue homeostasis  glycoprotein binding  fibronectin binding  protease binding  cell migration involved in sprouting angiogenesis  actin binding  integrin binding  protein binding  basement membrane  cytoplasm  plasma membrane  plasma membrane  plasma membrane  focal adhesion  focal adhesion  cellular calcium ion homeostasis  cellular defense response  homophilic cell adhesion via plasma membrane adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  calcium-independent cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of cell proliferation  negative regulation of cell proliferation  integrin complex  germ cell migration  visual learning  external side of plasma membrane  cell surface  regulation of collagen catabolic process  positive regulation of cell-substrate adhesion  positive regulation of neuron projection development  intercalated disc  response to activity  coreceptor activity  membrane  cell migration  protein kinase binding  protein domain specific binding  C-X3-C chemokine binding  formation of radial glial scaffolds  lamellipodium  hemidesmosome  filopodium  B cell differentiation  extracellular matrix organization  positive regulation of cell migration  negative regulation of cell projection organization  cell-substrate adhesion  neuromuscular junction  receptor internalization  cleavage furrow  protein complex binding  ruffle membrane  ruffle membrane  protein transport within lipid bilayer  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  integrin alpha1-beta1 complex  integrin alpha2-beta1 complex  integrin alpha3-beta1 complex  integrin alpha7-beta1 complex  integrin alpha8-beta1 complex  integrin alpha9-beta1 complex  integrin alpha10-beta1 complex  integrin alpha11-beta1 complex  response to gonadotropin  negative regulation of Rho protein signal transduction  myelin sheath abaxonal region  peptide binding  sarcolemma  melanosome  response to drug  positive regulation of apoptotic process  stress fiber assembly  dendritic spine  receptor complex  laminin binding  positive regulation of MAPK cascade  positive regulation of GTPase activity  membrane raft  sarcomere organization  negative regulation of neuron differentiation  positive regulation of endocytosis  viral entry into host cell  metal ion binding  protein heterodimerization activity  protein heterodimerization activity  mesodermal cell differentiation  perinuclear region of cytoplasm  axon extension  dendrite morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  cell adhesion molecule binding  leukocyte migration  leukocyte tethering or rolling  alpha-actinin binding  regulation of cell cycle  cardiac muscle cell differentiation  recycling endosome  maternal process involved in female pregnancy  extracellular exosome  bicellular tight junction assembly  cellular response to mechanical stimulus  cellular response to vitamin D  cellular response to low-density lipoprotein particle stimulus  invadopodium membrane  cellular response to ionizing radiation  positive regulation of establishment of protein localization to plasma membrane  synaptic membrane  collagen binding involved in cell-matrix adhesion  negative regulation of anoikis  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  virus receptor activity  acrosomal vesicle  in utero embryonic development  cell fate specification  ruffle  tissue homeostasis  glycoprotein binding  fibronectin binding  protease binding  cell migration involved in sprouting angiogenesis  actin binding  integrin binding  protein binding  basement membrane  cytoplasm  plasma membrane  plasma membrane  plasma membrane  focal adhesion  focal adhesion  cellular calcium ion homeostasis  cellular defense response  homophilic cell adhesion via plasma membrane adhesion molecules  leukocyte cell-cell adhesion  cell-matrix adhesion  calcium-independent cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of cell proliferation  negative regulation of cell proliferation  integrin complex  germ cell migration  visual learning  external side of plasma membrane  cell surface  regulation of collagen catabolic process  positive regulation of cell-substrate adhesion  positive regulation of neuron projection development  intercalated disc  response to activity  coreceptor activity  membrane  cell migration  protein kinase binding  protein domain specific binding  C-X3-C chemokine binding  formation of radial glial scaffolds  lamellipodium  hemidesmosome  filopodium  B cell differentiation  extracellular matrix organization  positive regulation of cell migration  negative regulation of cell projection organization  cell-substrate adhesion  neuromuscular junction  receptor internalization  cleavage furrow  protein complex binding  ruffle membrane  ruffle membrane  protein transport within lipid bilayer  cell-cell adhesion mediated by integrin  heterotypic cell-cell adhesion  integrin alpha1-beta1 complex  integrin alpha2-beta1 complex  integrin alpha3-beta1 complex  integrin alpha7-beta1 complex  integrin alpha8-beta1 complex  integrin alpha9-beta1 complex  integrin alpha10-beta1 complex  integrin alpha11-beta1 complex  response to gonadotropin  negative regulation of Rho protein signal transduction  myelin sheath abaxonal region  peptide binding  sarcolemma  melanosome  response to drug  positive regulation of apoptotic process  stress fiber assembly  dendritic spine  receptor complex  laminin binding  positive regulation of MAPK cascade  positive regulation of GTPase activity  membrane raft  sarcomere organization  negative regulation of neuron differentiation  positive regulation of endocytosis  viral entry into host cell  metal ion binding  protein heterodimerization activity  protein heterodimerization activity  mesodermal cell differentiation  perinuclear region of cytoplasm  axon extension  dendrite morphogenesis  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  cell adhesion molecule binding  leukocyte migration  leukocyte tethering or rolling  alpha-actinin binding  regulation of cell cycle  cardiac muscle cell differentiation  recycling endosome  maternal process involved in female pregnancy  extracellular exosome  bicellular tight junction assembly  cellular response to mechanical stimulus  cellular response to vitamin D  cellular response to low-density lipoprotein particle stimulus  invadopodium membrane  cellular response to ionizing radiation  positive regulation of establishment of protein localization to plasma membrane  synaptic membrane  collagen binding involved in cell-matrix adhesion  negative regulation of anoikis  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]    mCalpain and friends in Cell motility [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Cells and Molecules involved in local acute inflammatory response [Genes]    B Cell Survival Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    uCalpain and friends in Cell spread [Genes]    Monocyte and its Surface Molecules [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Eph Kinases and ephrins support platelet aggregation [Genes]    Integrin Signaling Pathway [Genes]    Adhesion Molecules on Lymphocyte [Genes]   
Pathways : KEGGRap1 signaling pathway    Phagosome    PI3K-Akt signaling pathway    Axon guidance    Focal adhesion    ECM-receptor interaction    Cell adhesion molecules (CAMs)    Leukocyte transendothelial migration    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Pertussis    Leishmaniasis    Toxoplasmosis    Pathways in cancer    Proteoglycans in cancer    Small cell lung cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB1
Atlas of Cancer Signalling NetworkITGB1
Wikipedia pathwaysITGB1
Orthology - Evolution
OrthoDB3688
GeneTree (enSembl)ENSG00000150093
Phylogenetic Trees/Animal Genes : TreeFamITGB1
HOVERGENP05556
HOGENOMP05556
Homologs : HomoloGeneITGB1
Homology/Alignments : Family Browser (UCSC)ITGB1
Gene fusions - Rearrangements
Fusion Cancer (Beijing)ITGB1 [10p11.22]  -  ZNF717 [3p12.3]  [FUSC002864]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB1
dbVarITGB1
ClinVarITGB1
1000_GenomesITGB1 
Exome Variant ServerITGB1
ExAC (Exome Aggregation Consortium)ITGB1 (select the gene name)
Genetic variants : HAPMAP3688
Genomic Variants (DGV)ITGB1 [DGVbeta]
DECIPHER (Syndromes)10:33189246-33247293  ENSG00000150093
CONAN: Copy Number AnalysisITGB1 
Mutations
ICGC Data PortalITGB1 
TCGA Data PortalITGB1 
Broad Tumor PortalITGB1
OASIS PortalITGB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB1
DgiDB (Drug Gene Interaction Database)ITGB1
DoCM (Curated mutations)ITGB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB1 (select a term)
intoGenITGB1
Cancer3DITGB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135630   
Orphanet
MedgenITGB1
Genetic Testing Registry ITGB1
NextProtP05556 [Medical]
TSGene3688
GENETestsITGB1
Huge Navigator ITGB1 [HugePedia]
snp3D : Map Gene to Disease3688
BioCentury BCIQITGB1
ClinGenITGB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3688
Chemical/Pharm GKB GenePA29953
Clinical trialITGB1
Miscellaneous
canSAR (ICR)ITGB1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB1
EVEXITGB1
GoPubMedITGB1
iHOPITGB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:35 CEST 2017

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