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ITGB2 (integrin subunit beta 2)

Identity

Alias_namesCD18
MFI7
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Alias_symbol (synonym)LFA-1
MAC-1
Other aliasLAD
LCAMB
MF17
HGNC (Hugo) ITGB2
LocusID (NCBI) 3689
Atlas_Id 41018
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46305869 and ends at 46340965 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LRRC75A-AS1 (17p11.2) / ITGB2 (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGB2   6155
LRG (Locus Reference Genomic)LRG_76
Cards
Entrez_Gene (NCBI)ITGB2  3689  integrin subunit beta 2
AliasesCD18; LAD; LCAMB; LFA-1; 
MAC-1; MF17; MFI7
GeneCards (Weizmann)ITGB2
Ensembl hg19 (Hinxton)ENSG00000160255 [Gene_View]  chr21:46305869-46340965 [Contig_View]  ITGB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160255 [Gene_View]  chr21:46305869-46340965 [Contig_View]  ITGB2 [Vega]
ICGC DataPortalENSG00000160255
TCGA cBioPortalITGB2
AceView (NCBI)ITGB2
Genatlas (Paris)ITGB2
WikiGenes3689
SOURCE (Princeton)ITGB2
Genetics Home Reference (NIH)ITGB2
Genomic and cartography
GoldenPath hg19 (UCSC)ITGB2  -     chr21:46305869-46340965 -  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGB2  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblITGB2 - 21q22.3 [CytoView hg19]  ITGB2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIITGB2 [Mapview hg19]  ITGB2 [Mapview hg38]
OMIM116920   600065   
Gene and transcription
Genbank (Entrez)AB208909 AK095992 AK097216 AK097864 AK128344
RefSeq transcript (Entrez)NM_000211 NM_001127491 NM_001303238
RefSeq genomic (Entrez)NC_000021 NC_018932 NG_007270 NT_011512 NW_004929427
Consensus coding sequences : CCDS (NCBI)ITGB2
Cluster EST : UnigeneHs.375957 [ NCBI ]
CGAP (NCI)Hs.375957
Alternative Splicing GalleryENSG00000160255
Gene ExpressionITGB2 [ NCBI-GEO ]   ITGB2 [ EBI - ARRAY_EXPRESS ]   ITGB2 [ SEEK ]   ITGB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3689
GTEX Portal (Tissue expression)ITGB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05107   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05107  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05107
Splice isoforms : SwissVarP05107
PhosPhoSitePlusP05107
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)Integrin_bsu    Integrin_bsu-2    Integrin_bsu_cyt_dom    Integrin_bsu_N    Integrin_bsu_tail    Integrin_dom    Plexin-like_fold    VWF_A   
Domain families : Pfam (Sanger)Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam08725    pfam07965    pfam00362   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
Conserved Domain (NCBI)ITGB2
DMDM Disease mutations3689
Blocks (Seattle)ITGB2
PDB (SRS)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
PDB (PDBSum)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
PDB (IMB)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
PDB (RSDB)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
Structural Biology KnowledgeBase1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
SCOP (Structural Classification of Proteins)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
CATH (Classification of proteins structures)1JX3    1L3Y    1YUK    2JF1    2P26    2P28    2V7D    3K6S    3K71    3K72    4NEH    4NEN   
SuperfamilyP05107
Human Protein AtlasENSG00000160255
Peptide AtlasP05107
HPRD02506
IPIIPI00291792   IPI00978363   IPI00103356   IPI00795567   IPI00974504   IPI01009151   IPI00975496   IPI00978148   IPI00746851   IPI00974291   IPI00977909   IPI00979940   IPI00976155   
Protein Interaction databases
DIP (DOE-UCLA)P05107
IntAct (EBI)P05107
FunCoupENSG00000160255
BioGRIDITGB2
STRING (EMBL)ITGB2
ZODIACITGB2
Ontologies - Pathways
QuickGOP05107
Ontology : AmiGOglycoprotein binding  leukocyte migration involved in inflammatory response  protein binding  plasma membrane  apoptotic process  inflammatory response  cell adhesion  leukocyte cell-cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  cell-cell signaling  aging  integrin complex  regulation of cell shape  cell surface  membrane  protein kinase binding  natural killer cell activation  secretory granule  extracellular matrix organization  ICAM-3 receptor activity  neutrophil chemotaxis  receptor internalization  protein complex binding  heterotypic cell-cell adhesion  toll-like receptor 4 signaling pathway  integrin alphaL-beta2 complex  endodermal cell differentiation  receptor clustering  receptor complex  endothelial cell migration  cellular extravasation  positive regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  metal ion binding  protein heterodimerization activity  regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  cell adhesion molecule binding  leukocyte migration  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  extracellular vesicle  
Ontology : EGO-EBIglycoprotein binding  leukocyte migration involved in inflammatory response  protein binding  plasma membrane  apoptotic process  inflammatory response  cell adhesion  leukocyte cell-cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  cell-cell signaling  aging  integrin complex  regulation of cell shape  cell surface  membrane  protein kinase binding  natural killer cell activation  secretory granule  extracellular matrix organization  ICAM-3 receptor activity  neutrophil chemotaxis  receptor internalization  protein complex binding  heterotypic cell-cell adhesion  toll-like receptor 4 signaling pathway  integrin alphaL-beta2 complex  endodermal cell differentiation  receptor clustering  receptor complex  endothelial cell migration  cellular extravasation  positive regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  metal ion binding  protein heterodimerization activity  regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  cell adhesion molecule binding  leukocyte migration  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  cellular response to low-density lipoprotein particle stimulus  extracellular vesicle  
Pathways : BIOCARTACells and Molecules involved in local acute inflammatory response [Genes]    T Cytotoxic Cell Surface Molecules [Genes]    CTL mediated immune response against target cells [Genes]    Adhesion and Diapedesis of Granulocytes [Genes]    T Helper Cell Surface Molecules [Genes]    Adhesion and Diapedesis of Lymphocytes [Genes]    Monocyte and its Surface Molecules [Genes]    Adhesion Molecules on Lymphocyte [Genes]    B Lymphocyte Cell Surface Molecules [Genes]    Neutrophil and Its Surface Molecules [Genes]   
Pathways : KEGGRap1 signaling pathway    Phagosome    Hippo signaling pathway    Cell adhesion molecules (CAMs)    Natural killer cell mediated cytotoxicity    Leukocyte transendothelial migration    Regulation of actin cytoskeleton    Pertussis    Legionellosis    Leishmaniasis    Malaria    Amoebiasis    Staphylococcus aureus infection    Tuberculosis    HTLV-I infection    Rheumatoid arthritis    Viral myocarditis   
NDEx NetworkITGB2
Atlas of Cancer Signalling NetworkITGB2
Wikipedia pathwaysITGB2
Orthology - Evolution
OrthoDB3689
GeneTree (enSembl)ENSG00000160255
Phylogenetic Trees/Animal Genes : TreeFamITGB2
HOVERGENP05107
HOGENOMP05107
Homologs : HomoloGeneITGB2
Homology/Alignments : Family Browser (UCSC)ITGB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB2
dbVarITGB2
ClinVarITGB2
1000_GenomesITGB2 
Exome Variant ServerITGB2
ExAC (Exome Aggregation Consortium)ITGB2 (select the gene name)
Genetic variants : HAPMAP3689
Genomic Variants (DGV)ITGB2 [DGVbeta]
DECIPHER (Syndromes)21:46305869-46340965  ENSG00000160255
CONAN: Copy Number AnalysisITGB2 
Mutations
ICGC Data PortalITGB2 
TCGA Data PortalITGB2 
Broad Tumor PortalITGB2
OASIS PortalITGB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch ITGB2
DgiDB (Drug Gene Interaction Database)ITGB2
DoCM (Curated mutations)ITGB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB2 (select a term)
intoGenITGB2
Cancer3DITGB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116920    600065   
Orphanet14415   
MedgenITGB2
Genetic Testing Registry ITGB2
NextProtP05107 [Medical]
TSGene3689
GENETestsITGB2
Huge Navigator ITGB2 [HugePedia]
snp3D : Map Gene to Disease3689
BioCentury BCIQITGB2
ClinGenITGB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3689
Chemical/Pharm GKB GenePA29955
Clinical trialITGB2
Miscellaneous
canSAR (ICR)ITGB2 (select the gene name)
Probes
Litterature
PubMed435 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB2
EVEXITGB2
GoPubMedITGB2
iHOPITGB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:05:35 CEST 2017

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