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ITGB3 (integrin subunit beta 3)

Identity

Alias_namesGP3A
integrin
Alias_symbol (synonym)CD61
GPIIIa
Other aliasBDPLT16
BDPLT2
GT
HGNC (Hugo) ITGB3
LocusID (NCBI) 3690
Atlas_Id 41019
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47253842 and ends at 47312711 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GOLGA1 (9q33.3) / ITGB3 (17q21.32)ITGB3 (17q21.32) / FMN1 (15q13.3)ITGB3 (17q21.32) / PATJ (1p31.3)
ITGB3 (17q21.32) / TTC12 (11q23.2)ITGB3 (17q21.32) / YARS (1p35.1)KIF4A (Xq13.1) / ITGB3 (17q21.32)
SCG3 (15q21.2) / ITGB3 (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Skin: Melanoma


External links

Nomenclature
HGNC (Hugo)ITGB3   6156
LRG (Locus Reference Genomic)LRG_481
Cards
Entrez_Gene (NCBI)ITGB3  3690  integrin subunit beta 3
AliasesBDPLT16; BDPLT2; CD61; GP3A; 
GPIIIa; GT
GeneCards (Weizmann)ITGB3
Ensembl hg19 (Hinxton)ENSG00000259207 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000259207 [Gene_View]  ENSG00000259207 [Sequence]  chr17:47253842-47312711 [Contig_View]  ITGB3 [Vega]
ICGC DataPortalENSG00000259207
TCGA cBioPortalITGB3
AceView (NCBI)ITGB3
Genatlas (Paris)ITGB3
WikiGenes3690
SOURCE (Princeton)ITGB3
Genetics Home Reference (NIH)ITGB3
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB3  -     chr17:47253842-47312711 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB3  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblITGB3 - 17q21.32 [CytoView hg19]  ITGB3 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIITGB3 [Mapview hg19]  ITGB3 [Mapview hg38]
OMIM173470   187800   273800   608446   
Gene and transcription
Genbank (Entrez)AY826979 BC127666 BC127667 BE389074 BE893993
RefSeq transcript (Entrez)NM_000212
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGB3
Cluster EST : UnigeneHs.218040 [ NCBI ]
CGAP (NCI)Hs.218040
Alternative Splicing GalleryENSG00000259207
Gene ExpressionITGB3 [ NCBI-GEO ]   ITGB3 [ EBI - ARRAY_EXPRESS ]   ITGB3 [ SEEK ]   ITGB3 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3690
GTEX Portal (Tissue expression)ITGB3
Human Protein AtlasENSG00000259207-ITGB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05106   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05106  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05106
Splice isoforms : SwissVarP05106
PhosPhoSitePlusP05106
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integrin_beta-3    Integrin_beta_N    Integrin_bsu    Integrin_bsu_cyt_dom    Integrin_bsu_tail    Integrin_bsu_tail_dom_sf    Integrin_bsu_VWA    Integrin_dom_sf    PSI    vWFA_dom_sf   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)INB (SM00187)  Integrin_b_cyt (SM01241)  Integrin_B_tail (SM01242)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB3
DMDM Disease mutations3690
Blocks (Seattle)ITGB3
PDB (SRS)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
PDB (PDBSum)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
PDB (IMB)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
PDB (RSDB)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
Structural Biology KnowledgeBase1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
SCOP (Structural Classification of Proteins)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
CATH (Classification of proteins structures)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2N9Y    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB    6AVQ    6AVR    6AVU   
SuperfamilyP05106
Human Protein Atlas [tissue]ENSG00000259207-ITGB3 [tissue]
Peptide AtlasP05106
HPRD01428
IPIIPI00303283   IPI00220350   IPI00220351   IPI00786871   
Protein Interaction databases
DIP (DOE-UCLA)P05106
IntAct (EBI)P05106
FunCoupENSG00000259207
BioGRIDITGB3
STRING (EMBL)ITGB3
ZODIACITGB3
Ontologies - Pathways
QuickGOP05106
Ontology : AmiGOvirus receptor activity  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  fibronectin binding  fibronectin binding  protease binding  platelet degranulation  protein disulfide isomerase activity  platelet-derived growth factor receptor binding  integrin binding  integrin binding  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  focal adhesion  focal adhesion  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  blood coagulation  integrin complex  integrin complex  cell surface  cell surface  cell surface  positive regulation of endothelial cell migration  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  smooth muscle cell migration  coreceptor activity  cell migration  fibroblast growth factor binding  enzyme binding  C-X3-C chemokine binding  platelet activation  extracellular matrix organization  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule membrane  lamellipodium membrane  filopodium membrane  microvillus membrane  cell-substrate adhesion  insulin-like growth factor I binding  activation of protein kinase activity  negative regulation of lipid transport  ruffle membrane  cell adhesion mediated by integrin  cell adhesion mediated by integrin  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alphav-beta3 complex  tube development  alphav-beta3 integrin-PKCalpha complex  alphav-beta3 integrin-IGF-1-IGF1R complex  alphav-beta3 integrin-HMGB1 complex  apolipoprotein A-I-mediated signaling pathway  neuregulin binding  wound healing  melanosome  identical protein binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  receptor complex  apoptotic cell clearance  regulation of bone resorption  negative regulation of low-density lipoprotein particle receptor biosynthetic process  viral entry into host cell  vascular endothelial growth factor receptor signaling pathway  mesodermal cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipoprotein metabolic process  cell adhesion molecule binding  extracellular matrix binding  leukocyte migration  negative chemotaxis  angiogenesis involved in wound healing  fibrinogen binding  extracellular exosome  platelet aggregation  alphav-beta3 integrin-vitronectin complex  
Ontology : EGO-EBIvirus receptor activity  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  fibronectin binding  fibronectin binding  protease binding  platelet degranulation  protein disulfide isomerase activity  platelet-derived growth factor receptor binding  integrin binding  integrin binding  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  focal adhesion  focal adhesion  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  blood coagulation  integrin complex  integrin complex  cell surface  cell surface  cell surface  positive regulation of endothelial cell migration  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  smooth muscle cell migration  coreceptor activity  cell migration  fibroblast growth factor binding  enzyme binding  C-X3-C chemokine binding  platelet activation  extracellular matrix organization  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule membrane  lamellipodium membrane  filopodium membrane  microvillus membrane  cell-substrate adhesion  insulin-like growth factor I binding  activation of protein kinase activity  negative regulation of lipid transport  ruffle membrane  cell adhesion mediated by integrin  cell adhesion mediated by integrin  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alphav-beta3 complex  tube development  alphav-beta3 integrin-PKCalpha complex  alphav-beta3 integrin-IGF-1-IGF1R complex  alphav-beta3 integrin-HMGB1 complex  apolipoprotein A-I-mediated signaling pathway  neuregulin binding  wound healing  melanosome  identical protein binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  receptor complex  apoptotic cell clearance  regulation of bone resorption  negative regulation of low-density lipoprotein particle receptor biosynthetic process  viral entry into host cell  vascular endothelial growth factor receptor signaling pathway  mesodermal cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipoprotein metabolic process  cell adhesion molecule binding  extracellular matrix binding  leukocyte migration  negative chemotaxis  angiogenesis involved in wound healing  fibrinogen binding  extracellular exosome  platelet aggregation  alphav-beta3 integrin-vitronectin complex  
Pathways : KEGG   
NDEx NetworkITGB3
Atlas of Cancer Signalling NetworkITGB3
Wikipedia pathwaysITGB3
Orthology - Evolution
OrthoDB3690
GeneTree (enSembl)ENSG00000259207
Phylogenetic Trees/Animal Genes : TreeFamITGB3
HOVERGENP05106
HOGENOMP05106
Homologs : HomoloGeneITGB3
Homology/Alignments : Family Browser (UCSC)ITGB3
Gene fusions - Rearrangements
Fusion : QuiverITGB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB3
dbVarITGB3
ClinVarITGB3
1000_GenomesITGB3 
Exome Variant ServerITGB3
ExAC (Exome Aggregation Consortium)ENSG00000259207
GNOMAD BrowserENSG00000259207
Varsome BrowserITGB3
Genetic variants : HAPMAP3690
Genomic Variants (DGV)ITGB3 [DGVbeta]
DECIPHERITGB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB3 
Mutations
ICGC Data PortalITGB3 
TCGA Data PortalITGB3 
Broad Tumor PortalITGB3
OASIS PortalITGB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB3
DgiDB (Drug Gene Interaction Database)ITGB3
DoCM (Curated mutations)ITGB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB3 (select a term)
intoGenITGB3
Cancer3DITGB3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173470    187800    273800    608446   
Orphanet17007    3382    8692   
DisGeNETITGB3
MedgenITGB3
Genetic Testing Registry ITGB3
NextProtP05106 [Medical]
TSGene3690
GENETestsITGB3
Target ValidationITGB3
Huge Navigator ITGB3 [HugePedia]
snp3D : Map Gene to Disease3690
BioCentury BCIQITGB3
ClinGenITGB3 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3690
Chemical/Pharm GKB GenePA205
Clinical trialITGB3
Miscellaneous
canSAR (ICR)ITGB3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB3
EVEXITGB3
GoPubMedITGB3
iHOPITGB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:29:47 CEST 2018

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