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ITGB3 (integrin subunit beta 3)

Identity

Other namesBDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
HGNC (Hugo) ITGB3
LocusID (NCBI) 3690
Atlas_Id 41019
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 45331208 and ends at 45390077 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GOLGA1 (9q33.3) / ITGB3 (17q21.32)ITGB3 (17q21.32) / FMN1 (15q13.3)ITGB3 (17q21.32) / PATJ (1p31.3)
ITGB3 (17q21.32) / TTC12 (11q23.2)ITGB3 (17q21.32) / YARS (1p35.1)KIF4A (Xq13.1) / ITGB3 (17q21.32)
SCG3 (15q21.2) / ITGB3 (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Skin: Melanoma

External links

Nomenclature
HGNC (Hugo)ITGB3   6156
Cards
Entrez_Gene (NCBI)ITGB3  3690  integrin subunit beta 3
AliasesBDPLT16; BDPLT2; CD61; GP3A; 
GPIIIa; GT
GeneCards (Weizmann)ITGB3
Ensembl hg19 (Hinxton)ENSG00000259207 [Gene_View]  chr17:45331208-45390077 [Contig_View]  ITGB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000259207 [Gene_View]  chr17:45331208-45390077 [Contig_View]  ITGB3 [Vega]
ICGC DataPortalENSG00000259207
TCGA cBioPortalITGB3
AceView (NCBI)ITGB3
Genatlas (Paris)ITGB3
WikiGenes3690
SOURCE (Princeton)ITGB3
Genomic and cartography
GoldenPath hg19 (UCSC)ITGB3  -     chr17:45331208-45390077 +  17q21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGB3  -     17q21.32   [Description]    (hg38-Dec_2013)
EnsemblITGB3 - 17q21.32 [CytoView hg19]  ITGB3 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBIITGB3 [Mapview hg19]  ITGB3 [Mapview hg38]
OMIM173470   187800   273800   608446   
Gene and transcription
Genbank (Entrez)AY826979 BC127666 BC127667 BE389074 BE893993
RefSeq transcript (Entrez)NM_000212
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_008332 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)ITGB3
Cluster EST : UnigeneHs.218040 [ NCBI ]
CGAP (NCI)Hs.218040
Alternative Splicing GalleryENSG00000259207
Gene ExpressionITGB3 [ NCBI-GEO ]   ITGB3 [ EBI - ARRAY_EXPRESS ]   ITGB3 [ SEEK ]   ITGB3 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3690
GTEX Portal (Tissue expression)ITGB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05106 (Uniprot)
NextProtP05106  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05106
Splice isoforms : SwissVarP05106 (Swissvar)
PhosPhoSitePlusP05106
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integrin_beta-3    Integrin_bsu    Integrin_bsu_cyt_dom    Integrin_bsu_N    Integrin_bsu_tail    Integrin_dom    Plexin-like_fold    VWF_A   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam07965    pfam00362   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
DMDM Disease mutations3690
Blocks (Seattle)ITGB3
PDB (SRS)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (PDBSum)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (IMB)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
PDB (RSDB)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
Structural Biology KnowledgeBase1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
SCOP (Structural Classification of Proteins)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
CATH (Classification of proteins structures)1JV2    1KUP    1KUZ    1L5G    1M1X    1M8O    1MIZ    1MK7    1MK9    1RN0    1S4X    1TYE    1U8C    2INI    2K9J    2KNC    2KV9    2L1C    2L91    2LJD    2LJE    2LJF    2MTP    2Q6W    2RMZ    2RN0    2VC2    2VDK    2VDL    2VDM    2VDN    2VDO    2VDP    2VDQ    2VDR    3FCS    3FCU    3IJE    3NID    3NIF    3NIG    3T3M    3T3P    3ZDX    3ZDY    3ZDZ    3ZE0    3ZE1    3ZE2    4CAK    4G1E    4G1M    4MMX    4MMY    4MMZ    4O02    4Z7N    4Z7O    4Z7Q    5HDB   
SuperfamilyP05106
Human Protein AtlasENSG00000259207
Peptide AtlasP05106
HPRD01428
IPIIPI00303283   IPI00220350   IPI00220351   IPI00786871   
Protein Interaction databases
DIP (DOE-UCLA)P05106
IntAct (EBI)P05106
FunCoupENSG00000259207
BioGRIDITGB3
STRING (EMBL)ITGB3
ZODIACITGB3
Ontologies - Pathways
QuickGOP05106
Ontology : AmiGOvirus receptor activity  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  fibronectin binding  protease binding  platelet degranulation  protein disulfide isomerase activity  platelet-derived growth factor receptor binding  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  protein folding  cell-substrate junction assembly  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin-mediated signaling pathway  blood coagulation  integrin complex  cell surface  positive regulation of endothelial cell migration  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  smooth muscle cell migration  coreceptor activity  cell growth  cell migration  enzyme binding  C-X3-C chemokine binding  platelet activation  extracellular matrix organization  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule membrane  lamellipodium membrane  filopodium membrane  microvillus membrane  cell-substrate adhesion  activation of protein kinase activity  negative regulation of lipid transport  ruffle membrane  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alphav-beta3 complex  tube development  apolipoprotein A-I-mediated signaling pathway  wound healing  melanosome  identical protein binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  receptor complex  regulation of bone resorption  negative regulation of low-density lipoprotein particle receptor biosynthetic process  viral entry into host cell  vascular endothelial growth factor receptor signaling pathway  mesodermal cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipoprotein metabolic process  cell adhesion molecule binding  extracellular matrix binding  leukocyte migration  negative chemotaxis  angiogenesis involved in wound healing  extracellular exosome  platelet aggregation  alphav-beta3 integrin-vitronectin complex  
Ontology : EGO-EBIvirus receptor activity  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  fibronectin binding  protease binding  platelet degranulation  protein disulfide isomerase activity  platelet-derived growth factor receptor binding  protein binding  nucleus  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  protein folding  cell-substrate junction assembly  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin-mediated signaling pathway  blood coagulation  integrin complex  cell surface  positive regulation of endothelial cell migration  negative regulation of macrophage derived foam cell differentiation  negative regulation of lipid storage  smooth muscle cell migration  coreceptor activity  cell growth  cell migration  enzyme binding  C-X3-C chemokine binding  platelet activation  extracellular matrix organization  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule membrane  lamellipodium membrane  filopodium membrane  microvillus membrane  cell-substrate adhesion  activation of protein kinase activity  negative regulation of lipid transport  ruffle membrane  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alphav-beta3 complex  tube development  apolipoprotein A-I-mediated signaling pathway  wound healing  melanosome  identical protein binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  receptor complex  regulation of bone resorption  negative regulation of low-density lipoprotein particle receptor biosynthetic process  viral entry into host cell  vascular endothelial growth factor receptor signaling pathway  mesodermal cell differentiation  positive regulation of peptidyl-tyrosine phosphorylation  negative regulation of lipoprotein metabolic process  cell adhesion molecule binding  extracellular matrix binding  leukocyte migration  negative chemotaxis  angiogenesis involved in wound healing  extracellular exosome  platelet aggregation  alphav-beta3 integrin-vitronectin complex  
Pathways : BIOCARTAPhospholipids as signalling intermediaries [Genes]    uCalpain and friends in Cell spread [Genes]   
Pathways : KEGGRap1 signaling pathway    Phagosome    PI3K-Akt signaling pathway    Osteoclast differentiation    Focal adhesion    ECM-receptor interaction    Hematopoietic cell lineage    Regulation of actin cytoskeleton    Thyroid hormone signaling pathway    Proteoglycans in cancer    MicroRNAs in cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB3
Atlas of Cancer Signalling NetworkITGB3
Wikipedia pathwaysITGB3
Orthology - Evolution
OrthoDB3690
GeneTree (enSembl)ENSG00000259207
Phylogenetic Trees/Animal Genes : TreeFamITGB3
Homologs : HomoloGeneITGB3
Homology/Alignments : Family Browser (UCSC)ITGB3
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerITGB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB3
dbVarITGB3
ClinVarITGB3
1000_GenomesITGB3 
Exome Variant ServerITGB3
ExAC (Exome Aggregation Consortium)ITGB3 (select the gene name)
Genetic variants : HAPMAP3690
Genomic Variants (DGV)ITGB3 [DGVbeta]
Mutations
ICGC Data PortalITGB3 
TCGA Data PortalITGB3 
Broad Tumor PortalITGB3
OASIS PortalITGB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB3
DgiDB (Drug Gene Interaction Database)ITGB3
DoCM (Curated mutations)ITGB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB3 (select a term)
intoGenITGB3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:45331208-45390077  ENSG00000259207
CONAN: Copy Number AnalysisITGB3 
Mutations and Diseases : HGMDITGB3
OMIM173470    187800    273800    608446   
MedgenITGB3
Genetic Testing Registry ITGB3
NextProtP05106 [Medical]
TSGene3690
GENETestsITGB3
Huge Navigator ITGB3 [HugePedia]
snp3D : Map Gene to Disease3690
BioCentury BCIQITGB3
ClinGenITGB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3690
Chemical/Pharm GKB GenePA205
Clinical trialITGB3
Miscellaneous
canSAR (ICR)ITGB3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB3
EVEXITGB3
GoPubMedITGB3
iHOPITGB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:55:35 CEST 2016

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