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ITGB4 (integrin subunit beta 4)

Identity

Alias_namesintegrin, beta 4
Alias_symbol (synonym)CD104
Other aliasGP150
HGNC (Hugo) ITGB4
LocusID (NCBI) 3691
Atlas_Id 41020
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75721328 and ends at 75757818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB4 (17q25.1) / LOC100507412 (-)ITGB4 (17q25.1) / MYO15B (17q25.1)ITGB4 (17q25.1) / NARF (17q25.3)
ITGB4 (17q25.1) / OTOP2 (17q25.1)ITGB4 (17q25.1) / PLSCR1 (3q24)ITGB4 (17q25.1) / SAP30BP (17q25.1)
ITGB4 (17q25.1) / SLC16A5 (17q25.1)ITGB4 (17q25.1) / TSPAN10 (17q25.3)ITGB4 (17q25.1) / USP37 (2q35)
RPUSD1 (16p13.3) / ITGB4 (17q25.1)ITGB4 17q25.1 / MYO15B 17q25.1ITGB4 17q25.1 / NARF 17q25.3
ITGB4 17q25.1 / OTOP2 17q25.1ITGB4 17q25.1 / SAP30BP 17q25.1ITGB4 17q25.1 / SLC16A5 17q25.1
ITGB4 17q25.1 / TSPAN10 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]

Solid Tumors TT_t1717q25q25ID102831 TT_t1717q25q25ID102832 TT_t1717q25q25ID102833 TT_t1717q25q25ID102834 TT_t1717q25q25ID102835
TT_t1717q25q25ID102836

External links

Nomenclature
HGNC (Hugo)ITGB4   6158
Cards
Entrez_Gene (NCBI)ITGB4  3691  integrin subunit beta 4
AliasesCD104; GP150
GeneCards (Weizmann)ITGB4
Ensembl hg19 (Hinxton)ENSG00000132470 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132470 [Gene_View]  ENSG00000132470 [Sequence]  chr17:75721328-75757818 [Contig_View]  ITGB4 [Vega]
ICGC DataPortalENSG00000132470
TCGA cBioPortalITGB4
AceView (NCBI)ITGB4
Genatlas (Paris)ITGB4
WikiGenes3691
SOURCE (Princeton)ITGB4
Genetics Home Reference (NIH)ITGB4
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB4  -     chr17:75721328-75757818 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB4  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathITGB4 - 17q25.1 [CytoView hg19]  ITGB4 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000132470
Mapping of homologs : NCBIITGB4 [Mapview hg19]  ITGB4 [Mapview hg38]
OMIM131800   147557   226650   226730   
Gene and transcription
Genbank (Entrez)AB208913 AF011375 AI318403 AK304792 AK310952
RefSeq transcript (Entrez)NM_000213 NM_001005619 NM_001005731 NM_001321123
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGB4
Alternative Splicing GalleryENSG00000132470
Gene ExpressionITGB4 [ NCBI-GEO ]   ITGB4 [ EBI - ARRAY_EXPRESS ]   ITGB4 [ SEEK ]   ITGB4 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3691
GTEX Portal (Tissue expression)ITGB4
Human Protein AtlasENSG00000132470-ITGB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16144
Splice isoforms : SwissVarP16144
PhosPhoSitePlusP16144
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    FN3 (PS50853)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)CalX-like_sf    Calx_beta    EGF-like_CS    EGF_extracell    FN3_dom    FN3_sf    I-EGF_1    Ig-like_fold    Integrin_beta_N    Integrin_bsu    Integrin_bsu-4    Integrin_bsu_tail    Integrin_bsu_tail_dom_sf    Integrin_bsu_VWA    PSI    vWFA_dom_sf   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    EGF_2 (PF07974)    fn3 (PF00041)    I-EGF_1 (PF18372)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam03160    pfam07974    pfam00041    pfam18372    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)Calx_beta (SM00237)  FN3 (SM00060)  INB (SM00187)  Integrin_B_tail (SM01242)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB4
DMDM Disease mutations3691
Blocks (Seattle)ITGB4
PDB (RSDB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB Europe1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB (PDBSum)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB (IMB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
Structural Biology KnowledgeBase1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
SCOP (Structural Classification of Proteins)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
CATH (Classification of proteins structures)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
SuperfamilyP16144
Human Protein Atlas [tissue]ENSG00000132470-ITGB4 [tissue]
Peptide AtlasP16144
HPRD00946
IPIIPI00027422   IPI00220845   IPI00220846   IPI00220847   IPI00220848   
Protein Interaction databases
DIP (DOE-UCLA)P16144
IntAct (EBI)P16144
FunCoupENSG00000132470
BioGRIDITGB4
STRING (EMBL)ITGB4
ZODIACITGB4
Ontologies - Pathways
QuickGOP16144
Ontology : AmiGOG protein-coupled receptor binding  integrin binding  protein binding  nucleolus  plasma membrane  plasma membrane  focal adhesion  autophagy  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  response to wounding  cell surface  cell surface  cell migration  cell junction  hemidesmosome  extracellular matrix organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  hemidesmosome assembly  nuclear membrane  insulin-like growth factor I binding  cell adhesion mediated by integrin  nail development  neuregulin binding  receptor complex  skin development  mesodermal cell differentiation  digestive tract development  cell motility  extracellular exosome  renal system development  amelogenesis  
Ontology : EGO-EBIG protein-coupled receptor binding  integrin binding  protein binding  nucleolus  plasma membrane  plasma membrane  focal adhesion  autophagy  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  response to wounding  cell surface  cell surface  cell migration  cell junction  hemidesmosome  extracellular matrix organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  hemidesmosome assembly  nuclear membrane  insulin-like growth factor I binding  cell adhesion mediated by integrin  nail development  neuregulin binding  receptor complex  skin development  mesodermal cell differentiation  digestive tract development  cell motility  extracellular exosome  renal system development  amelogenesis  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB4
Atlas of Cancer Signalling NetworkITGB4
Wikipedia pathwaysITGB4
Orthology - Evolution
OrthoDB3691
GeneTree (enSembl)ENSG00000132470
Phylogenetic Trees/Animal Genes : TreeFamITGB4
HOGENOMP16144
Homologs : HomoloGeneITGB4
Homology/Alignments : Family Browser (UCSC)ITGB4
Gene fusions - Rearrangements
Fusion : MitelmanITGB4/MYO15B [17q25.1/17q25.1]  
Fusion : MitelmanITGB4/NARF [17q25.1/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanITGB4/OTOP2 [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanITGB4/SAP30BP [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanITGB4/SLC16A5 [17q25.1/17q25.1]  [t(17;17)(q25;q25)]  
Fusion : MitelmanITGB4/TSPAN10 [17q25.1/17q25.3]  [t(17;17)(q25;q25)]  
Fusion PortalITGB4 17q25.1 MYO15B 17q25.1 OV
Fusion PortalITGB4 17q25.1 NARF 17q25.3 BRCA
Fusion PortalITGB4 17q25.1 OTOP2 17q25.1 LUSC
Fusion PortalITGB4 17q25.1 SAP30BP 17q25.1 LUAD
Fusion PortalITGB4 17q25.1 SLC16A5 17q25.1 BRCA
Fusion PortalITGB4 17q25.1 TSPAN10 17q25.3 LUAD
Fusion : QuiverITGB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB4
dbVarITGB4
ClinVarITGB4
1000_GenomesITGB4 
Exome Variant ServerITGB4
ExAC (Exome Aggregation Consortium)ENSG00000132470
GNOMAD BrowserENSG00000132470
Varsome BrowserITGB4
Genetic variants : HAPMAP3691
Genomic Variants (DGV)ITGB4 [DGVbeta]
DECIPHERITGB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB4 
Mutations
ICGC Data PortalITGB4 
TCGA Data PortalITGB4 
Broad Tumor PortalITGB4
OASIS PortalITGB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGB4
Mutations and Diseases : HGMDITGB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB4
DgiDB (Drug Gene Interaction Database)ITGB4
DoCM (Curated mutations)ITGB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB4 (select a term)
intoGenITGB4
Cancer3DITGB4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131800    147557    226650    226730   
Orphanet17236    19640    11429    11428   
DisGeNETITGB4
MedgenITGB4
Genetic Testing Registry ITGB4
NextProtP16144 [Medical]
TSGene3691
GENETestsITGB4
Target ValidationITGB4
Huge Navigator ITGB4 [HugePedia]
snp3D : Map Gene to Disease3691
BioCentury BCIQITGB4
ClinGenITGB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3691
Chemical/Pharm GKB GenePA29957
Clinical trialITGB4
Miscellaneous
canSAR (ICR)ITGB4 (select the gene name)
DataMed IndexITGB4
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB4
EVEXITGB4
GoPubMedITGB4
iHOPITGB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 16:49:50 CET 2020
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