ITGB4 (integrin subunit beta 4)

2003-02-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
CD104,GP150
FUSION GENES

Other Information

Locus ID:

NCBI: 3691
MIM: 147557
HGNC: 6158
Ensembl: ENSG00000132470

Variants:

dbSNP: 3691
ClinVar: 3691
TCGA: ENSG00000132470
COSMIC: ITGB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132470ENST00000200181P16144
ENSG00000132470ENST00000200181A0A024R8T0
ENSG00000132470ENST00000449880P16144
ENSG00000132470ENST00000450894P16144
ENSG00000132470ENST00000450894A0A024R8K7
ENSG00000132470ENST00000578318J3KSH9
ENSG00000132470ENST00000579662P16144
ENSG00000132470ENST00000579662A0A024R8K7
ENSG00000132470ENST00000582629J3QQL2
ENSG00000132470ENST00000584939J3QRK0

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Type I hemidesmosome assemblyREACTOMER-HSA-446107
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156113412004Palmitoylation supports assembly and function of integrin-tetraspanin complexes.92
146020712003Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155424312004Integrin beta4 signaling promotes tumor angiogenesis.83
129196772003The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.73
162587292005Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.64
121051882002Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.62
128654362003Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.60
169145182006beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.54
185505702008Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.54

Citation

Dessen P

ITGB4 (integrin subunit beta 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41020/itgb4