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ITGB4 (integrin, beta 4)

Identity

Other namesCD104
HGNC (Hugo) ITGB4
LocusID (NCBI) 3691
Location 17q25.1
Location_base_pair Starts at 73717516 and ends at 73753899 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGB4   6158
Cards
Entrez_Gene (NCBI)ITGB4  3691  integrin, beta 4
GeneCards (Weizmann)ITGB4
Ensembl (Hinxton)ENSG00000132470 [Gene_View]  chr17:73717516-73753899 [Contig_View]  ITGB4 [Vega]
ICGC DataPortalENSG00000132470
cBioPortalITGB4
AceView (NCBI)ITGB4
Genatlas (Paris)ITGB4
WikiGenes3691
SOURCE (Princeton)NM_000213 NM_001005619 NM_001005731
Genomic and cartography
GoldenPath (UCSC)ITGB4  -  17q25.1   chr17:73717516-73753899 +  17q25.1   [Description]    (hg19-Feb_2009)
EnsemblITGB4 - 17q25.1 [CytoView]
Mapping of homologs : NCBIITGB4 [Mapview]
OMIM131800   147557   226650   226730   
Gene and transcription
Genbank (Entrez)AB208913 AF011375 AI318403 AK304792 AK310952
RefSeq transcript (Entrez)NM_000213 NM_001005619 NM_001005731
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_007372 NT_010783 NW_001838454 NW_004929407
Consensus coding sequences : CCDS (NCBI)ITGB4
Cluster EST : UnigeneHs.632226 [ NCBI ]
CGAP (NCI)Hs.632226
Alternative Splicing : Fast-db (Paris)GSHG0012824
Alternative Splicing GalleryENSG00000132470
Gene ExpressionITGB4 [ NCBI-GEO ]     ITGB4 [ SEEK ]   ITGB4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16144 (Uniprot)
NextProtP16144  [Medical]
With graphics : InterProP16144
Splice isoforms : SwissVarP16144 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    FN3 (PS50853)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)Calx_beta [organisation]   EGF-like_CS [organisation]   EGF_extracell [organisation]   Fibronectin_type3 [organisation]   Ig-like_fold [organisation]   Integrin_bsu [organisation]   Integrin_bsu-4 [organisation]   Integrin_bsu_N [organisation]   Integrin_bsu_tail [organisation]   Plexin-like_fold [organisation]   VWF_A [organisation]  
Related proteins : CluSTrP16144
Domain families : Pfam (Sanger)Calx-beta (PF03160)    EGF_2 (PF07974)    fn3 (PF00041)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam03160    pfam07974    pfam00041    pfam07965    pfam00362   
Domain families : Smart (EMBL)Calx_beta (SM00237)  FN3 (SM00060)  INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
DMDM Disease mutations3691
Blocks (Seattle)P16144
PDB (SRS)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (PDBSum)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (IMB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (RSDB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
Human Protein AtlasENSG00000132470 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP16144
HPRD00946
IPIIPI00027422   IPI00220845   IPI00220846   IPI00220847   IPI00220848   
Protein Interaction databases
DIP (DOE-UCLA)P16144
IntAct (EBI)P16144
FunCoupENSG00000132470
BioGRIDITGB4
InParanoidP16144
Interologous Interaction database P16144
IntegromeDBITGB4
STRING (EMBL)ITGB4
Ontologies - Pathways
Ontology : AmiGOG-protein coupled receptor binding  receptor activity  protein binding  basement membrane  plasma membrane  plasma membrane  autophagy  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  multicellular organismal development  integrin complex  response to wounding  basal plasma membrane  cell surface  hemidesmosome  extracellular matrix organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  cell junction assembly  receptor complex  filopodium assembly  cell motility  extracellular vesicular exosome  
Ontology : EGO-EBIG-protein coupled receptor binding  receptor activity  protein binding  basement membrane  plasma membrane  plasma membrane  autophagy  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  multicellular organismal development  integrin complex  response to wounding  basal plasma membrane  cell surface  hemidesmosome  extracellular matrix organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  cell junction assembly  receptor complex  filopodium assembly  cell motility  extracellular vesicular exosome  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
Protein Interaction DatabaseITGB4
Wikipedia pathwaysITGB4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ITGB4
snp3D : Map Gene to Disease3691
SNP (GeneSNP Utah)ITGB4
SNP : HGBaseITGB4
Genetic variants : HAPMAPITGB4
Exome VariantITGB4
1000_GenomesITGB4 
ICGC programENSG00000132470 
Somatic Mutations in Cancer : COSMICITGB4 
CONAN: Copy Number AnalysisITGB4 
Mutations and Diseases : HGMDITGB4
Mutations and Diseases : intOGenITGB4
Genomic VariantsITGB4  ITGB4 [DGVbeta]
dbVarITGB4
ClinVarITGB4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM131800    147557    226650    226730   
MedgenITGB4
GENETestsITGB4
Disease Genetic AssociationITGB4
Huge Navigator ITGB4 [HugePedia]  ITGB4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneITGB4
Homology/Alignments : Family Browser (UCSC)ITGB4
Phylogenetic Trees/Animal Genes : TreeFamITGB4
Chemical/Protein Interactions : CTD3691
Chemical/Pharm GKB GenePA29957
Clinical trialITGB4
Cancer Resource (Charite)ENSG00000132470
Other databases
Probes
Litterature
PubMed185 Pubmed reference(s) in Entrez
CoreMineITGB4
iHOPITGB4
OncoSearchITGB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:51:21 CEST 2014

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