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ITGB4 (integrin, beta 4)

Identity

Other namesCD104
HGNC (Hugo) ITGB4
LocusID (NCBI) 3691
Location 17q25.1
Location_base_pair Starts at 73717516 and ends at 73753899 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGB4   6158
Entrez_Gene (NCBI)ITGB4  3691  integrin, beta 4
Cards
GeneCards (Weizmann)ITGB4
Ensembl (Hinxton)ENSG00000132470 [Gene_View]  chr17:73717516-73753899 [Contig_View]  ITGB4 [Vega]
AceView (NCBI)ITGB4
Genatlas (Paris)ITGB4
SOURCE (Stanford)NM_000213 NM_001005619 NM_001005731
Genomic and cartography
GoldenPath (UCSC)ITGB4  -  17q25.1   chr17:73717516-73753899 +  17q25.1   [Description]    (hg19-Feb_2009)
EnsemblITGB4 - 17q25.1 [CytoView]
Mapping of homologs : NCBIITGB4 [Mapview]
OMIM131800   147557   226650   226730   
Gene and transcription
Genbank (Entrez)AB208913 AF011375 AI318403 AK304792 AK310952
RefSeq transcript (SRS)NM_000213 NM_001005619 NM_001005731
RefSeq transcript (Entrez)NM_000213 NM_001005619 NM_001005731
RefSeq genomic (SRS)AC_000149 NC_000017 NC_018928 NG_007372 NT_010783 NW_001838454 NW_004078092
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_007372 NT_010783 NW_001838454 NW_004078092
Consensus coding sequences : CCDS (NCBI)ITGB4
Cluster EST : UnigeneHs.632226 [ SRS ] Hs.632226 [ NCBI ]
CGAP (NCI)Hs.632226
Alternative Splicing : Fast-db (Paris)GSHG0012824
Alternative Splicing GalleryENSG00000132470
Gene ExpressionITGB4 [ NCBI-GEO ]   ITGB4 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16144 (SRS) P16144 (Uniprot)
NextProtP16144
With graphics : InterProP16144
Splice isoforms : SwissVarP16144(Swissvar)
Domaine pattern : Prosite (SRS)EGF_1 (PS00022)    EGF_2 (PS01186)    FN3 (PS50853)    INTEGRIN_BETA (PS00243)    VWFA (PS50234)   
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    FN3 (PS50853)    INTEGRIN_BETA (PS00243)    VWFA (PS50234)   
Domains : Interpro (SRS)Calx_beta    EGF-like_CS    EGF_extracell    Fibronectin_type3    Ig-like_fold    Integrin_bsu    Integrin_bsu-4    Integrin_bsu_N    Integrin_bsu_tail    Plexin-like    Plexin-like_fold    VWF_A   
Domains : Interpro (EBI)Calx_beta    EGF-like_CS    EGF_extracell    Fibronectin_type3    Ig-like_fold    Integrin_bsu    Integrin_bsu-4    Integrin_bsu_N    Integrin_bsu_tail    Plexin-like    Plexin-like_fold    VWF_A   
Related proteins : CluSTrP16144
Domain families : Pfam (SRS)Calx-beta (PF03160)    EGF_2 (PF07974)    fn3 (PF00041)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    EGF_2 (PF07974)    fn3 (PF00041)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam03160    pfam07974    pfam00041    pfam07965    pfam00362   
Domain families : Smart (EMBL)Calx_beta (SM00237)  FN3 (SM00060)  INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
DMDM3691
Blocks (Seattle)P16144
PDB (SRS)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (PDBSum)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (IMB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
PDB (RSDB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A   
Human Protein AtlasENSG00000132470
HPRD00946
IPIIPI00027422   IPI00220845   IPI00220846   IPI00220847   IPI00220848   
Protein Interaction databases
DIP (DOE-UCLA)P16144
IntAct (EBI)P16144
FunCoupENSG00000132470
REACTOMEITGB4
Protein Interaction Database3691
BioGRIDITGB4
InParanoidP16144
Interologous Interaction database P16144
IntegromeDBITGB4
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ITGB4
SNP (GeneSNP Utah)ITGB4
SNP : HGBaseITGB4
Genetic variants : HAPMAPITGB4
Somatic Mutations in Cancer : COSMICITGB4 
CONAN: Copy Number AnalysisITGB4 
Mutations and Diseases : HGMDITGB4
OMIM131800    147557    226650    226730   
GENETests131800    147557    226650    226730   
Disease Genetic AssociationITGB4
Huge Navigator ITGB4 [HugePedia]  ITGB4 [HugeCancerGEM]
Genomic VariantsITGB4  ITGB4 [DGVbeta]
snp3D : Map Gene to Disease3691
General knowledge
Homologs : HomoloGeneITGB4
Homology/Alignments : Family Browser (UCSC)ITGB4
Phylogenetic Trees/Animal Genes : TreeFamITGB4
Chemical/Protein Interactions : CTD3691
Chemical/Pharm GKB GenePA29957
Clinical trialITGB4
Cancer Resource (Charite)ENSG00000132470
Ontology : AmiGOreceptor activity  receptor binding  protein binding  basement membrane  plasma membrane  plasma membrane  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  multicellular organismal development  integrin complex  response to wounding  basal plasma membrane  cell surface  hemidesmosome  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  cell junction assembly  filopodium assembly  cell motility  
Ontology : EGO-EBIreceptor activity  receptor binding  protein binding  basement membrane  plasma membrane  plasma membrane  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  multicellular organismal development  integrin complex  response to wounding  basal plasma membrane  cell surface  hemidesmosome  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  cell junction assembly  filopodium assembly  cell motility  
Pathways : KEGGECM-receptor interactionFocal adhesionRegulation of actin cytoskeletonCell Communication
Other databases
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
PubGeneITGB4
iHOPITGB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:36:24 CEST 2013
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