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ITGB4 (integrin subunit beta 4)

Identity

Alias (NCBI)CD104
GP150
HGNC (Hugo) ITGB4
HGNC Alias symbCD104
HGNC Previous nameintegrin, beta 4
LocusID (NCBI) 3691
Atlas_Id 41020
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75721459 and ends at 75757818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB4 (17q25.1) / LOC100507412 (-)ITGB4 (17q25.1) / MYO15B (17q25.1)ITGB4 (17q25.1) / NARF (17q25.3)
ITGB4 (17q25.1) / OTOP2 (17q25.1)ITGB4 (17q25.1) / PLSCR1 (3q24)ITGB4 (17q25.1) / SAP30BP (17q25.1)
ITGB4 (17q25.1) / SLC16A5 (17q25.1)ITGB4 (17q25.1) / TSPAN10 (17q25.3)ITGB4 (17q25.1) / USP37 (2q35)
RPUSD1 (16p13.3) / ITGB4 (17q25.1)ITGB4 17q25.1 / MYO15B 17q25.1ITGB4 17q25.1 / NARF 17q25.3
ITGB4 17q25.1 / OTOP2 17q25.1ITGB4 17q25.1 / SAP30BP 17q25.1ITGB4 17q25.1 / SLC16A5 17q25.1
ITGB4 17q25.1 / TSPAN10 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ITGB4   6158
Cards
Entrez_Gene (NCBI)ITGB4    integrin subunit beta 4
AliasesCD104; GP150
GeneCards (Weizmann)ITGB4
Ensembl hg19 (Hinxton)ENSG00000132470 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132470 [Gene_View]  ENSG00000132470 [Sequence]  chr17:75721459-75757818 [Contig_View]  ITGB4 [Vega]
ICGC DataPortalENSG00000132470
TCGA cBioPortalITGB4
AceView (NCBI)ITGB4
Genatlas (Paris)ITGB4
SOURCE (Princeton)ITGB4
Genetics Home Reference (NIH)ITGB4
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB4  -     chr17:75721459-75757818 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB4  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathITGB4 - 17q25.1 [CytoView hg19]  ITGB4 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000132470
Genome Data Viewer NCBIITGB4 [Mapview hg19]  
OMIM131800   147557   226650   226730   
Gene and transcription
Genbank (Entrez)AB208913 AF011375 AI318403 AK304792 AK310952
RefSeq transcript (Entrez)NM_000213 NM_001005619 NM_001005731 NM_001321123
Consensus coding sequences : CCDS (NCBI)ITGB4
Gene ExpressionITGB4 [ NCBI-GEO ]   ITGB4 [ EBI - ARRAY_EXPRESS ]   ITGB4 [ SEEK ]   ITGB4 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB4 [ Firebrowse - Broad ]
GenevisibleExpression of ITGB4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3691
GTEX Portal (Tissue expression)ITGB4
Human Protein AtlasENSG00000132470-ITGB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16144
PhosPhoSitePlusP16144
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    FN3 (PS50853)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)CalX-like_sf    Calx_beta    EGF-like_dom    EGF_extracell    FN3_dom    FN3_sf    I-EGF_1    Ig-like_fold    Integrin_beta_N    Integrin_bsu    Integrin_bsu-4    Integrin_bsu_tail    Integrin_bsu_tail_dom_sf    Integrin_bsu_VWA    PSI    vWFA_dom_sf   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    EGF_2 (PF07974)    fn3 (PF00041)    I-EGF_1 (PF18372)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam03160    pfam07974    pfam00041    pfam18372    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)Calx_beta (SM00237)  FN3 (SM00060)  INB (SM00187)  Integrin_B_tail (SM01242)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB4
PDB (RSDB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB Europe1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB (PDBSum)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
PDB (IMB)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
Structural Biology KnowledgeBase1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
SCOP (Structural Classification of Proteins)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
CATH (Classification of proteins structures)1QG3    2YRZ    3F7P    3F7Q    3F7R    3FQ4    3FSO    3H6A    4Q58    4WTW    4WTX    6GVK    6GVL   
SuperfamilyP16144
AlphaFold pdb e-kbP16144   
Human Protein Atlas [tissue]ENSG00000132470-ITGB4 [tissue]
HPRD00946
Protein Interaction databases
DIP (DOE-UCLA)P16144
IntAct (EBI)P16144
BioGRIDITGB4
STRING (EMBL)ITGB4
ZODIACITGB4
Ontologies - Pathways
QuickGOP16144
Ontology : AmiGOG protein-coupled receptor binding  integrin binding  protein binding  basement membrane  nucleolus  plasma membrane  plasma membrane  focal adhesion  autophagy  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  response to wounding  basal plasma membrane  cell surface  cell surface  cell migration  cell junction  hemidesmosome  extracellular matrix organization  collagen fibril organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  hemidesmosome assembly  nuclear membrane  insulin-like growth factor I binding  peripheral nervous system myelin formation  cell adhesion mediated by integrin  nail development  neuregulin binding  receptor complex  skin morphogenesis  filopodium assembly  mesodermal cell differentiation  cell motility  trophoblast cell migration  extracellular exosome  
Ontology : EGO-EBIG protein-coupled receptor binding  integrin binding  protein binding  basement membrane  nucleolus  plasma membrane  plasma membrane  focal adhesion  autophagy  cell adhesion  cell-matrix adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  response to wounding  basal plasma membrane  cell surface  cell surface  cell migration  cell junction  hemidesmosome  extracellular matrix organization  collagen fibril organization  cell leading edge  hemidesmosome assembly  hemidesmosome assembly  hemidesmosome assembly  nuclear membrane  insulin-like growth factor I binding  peripheral nervous system myelin formation  cell adhesion mediated by integrin  nail development  neuregulin binding  receptor complex  skin morphogenesis  filopodium assembly  mesodermal cell differentiation  cell motility  trophoblast cell migration  extracellular exosome  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB4
Atlas of Cancer Signalling NetworkITGB4
Wikipedia pathwaysITGB4
Orthology - Evolution
OrthoDB3691
GeneTree (enSembl)ENSG00000132470
Phylogenetic Trees/Animal Genes : TreeFamITGB4
Homologs : HomoloGeneITGB4
Homology/Alignments : Family Browser (UCSC)ITGB4
Gene fusions - Rearrangements
Fusion : MitelmanITGB4/MYO15B [17q25.1/17q25.1]  
Fusion : MitelmanITGB4/NARF [17q25.1/17q25.3]  
Fusion : MitelmanITGB4/OTOP2 [17q25.1/17q25.1]  
Fusion : MitelmanITGB4/SAP30BP [17q25.1/17q25.1]  
Fusion : MitelmanITGB4/SLC16A5 [17q25.1/17q25.1]  
Fusion : MitelmanITGB4/TSPAN10 [17q25.1/17q25.3]  
Fusion : QuiverITGB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB4
dbVarITGB4
ClinVarITGB4
MonarchITGB4
1000_GenomesITGB4 
Exome Variant ServerITGB4
GNOMAD BrowserENSG00000132470
Varsome BrowserITGB4
ACMGITGB4 variants
VarityP16144
Genomic Variants (DGV)ITGB4 [DGVbeta]
DECIPHERITGB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB4 
Mutations
ICGC Data PortalITGB4 
TCGA Data PortalITGB4 
Broad Tumor PortalITGB4
OASIS PortalITGB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGB4
Mutations and Diseases : HGMDITGB4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaITGB4
DgiDB (Drug Gene Interaction Database)ITGB4
DoCM (Curated mutations)ITGB4
CIViC (Clinical Interpretations of Variants in Cancer)ITGB4
Cancer3DITGB4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131800    147557    226650    226730   
Orphanet17236    19640    11429    11428   
DisGeNETITGB4
MedgenITGB4
Genetic Testing Registry ITGB4
NextProtP16144 [Medical]
GENETestsITGB4
Target ValidationITGB4
Huge Navigator ITGB4 [HugePedia]
ClinGenITGB4
Clinical trials, drugs, therapy
MyCancerGenomeITGB4
Protein Interactions : CTDITGB4
Pharm GKB GenePA29957
PharosP16144
Clinical trialITGB4
Miscellaneous
canSAR (ICR)ITGB4
HarmonizomeITGB4
DataMed IndexITGB4
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXITGB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:21 CEST 2021

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