Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ITGB5 (integrin subunit beta 5)

Identity

Alias_namesintegrin
Other alias-
HGNC (Hugo) ITGB5
LocusID (NCBI) 3693
Atlas_Id 41021
Location 3q21.2  [Link to chromosome band 3q21]
Location_base_pair Starts at 124761949 and ends at 124887305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ITGB5 (3q21.2) / ITGB5 (3q21.2)ITGB5 (3q21.2) / PARP14 (3q21.1)ITGB5 (3q21.2) / PPP6R3 (11q13.2)
NCOR2 (12q24.31) / ITGB5 (3q21.2)OIP5-AS1 (15q15.1) / ITGB5 (3q21.2)ITGB5 3q21.2 / PARP14 3q21.1
NCOR2 12q24.31 / ITGB5 3q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGB5   6160
Cards
Entrez_Gene (NCBI)ITGB5  3693  integrin subunit beta 5
Aliases
GeneCards (Weizmann)ITGB5
Ensembl hg19 (Hinxton)ENSG00000082781 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082781 [Gene_View]  chr3:124761949-124887305 [Contig_View]  ITGB5 [Vega]
ICGC DataPortalENSG00000082781
TCGA cBioPortalITGB5
AceView (NCBI)ITGB5
Genatlas (Paris)ITGB5
WikiGenes3693
SOURCE (Princeton)ITGB5
Genetics Home Reference (NIH)ITGB5
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB5  -     chr3:124761949-124887305 -  3q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB5  -     3q21.2   [Description]    (hg19-Feb_2009)
EnsemblITGB5 - 3q21.2 [CytoView hg19]  ITGB5 - 3q21.2 [CytoView hg38]
Mapping of homologs : NCBIITGB5 [Mapview hg19]  ITGB5 [Mapview hg38]
OMIM147561   
Gene and transcription
Genbank (Entrez)AK054968 AK130168 AK309551 AK315429 BC006541
RefSeq transcript (Entrez)NM_002213
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGB5
Cluster EST : UnigeneHs.536663 [ NCBI ]
CGAP (NCI)Hs.536663
Alternative Splicing GalleryENSG00000082781
Gene ExpressionITGB5 [ NCBI-GEO ]   ITGB5 [ EBI - ARRAY_EXPRESS ]   ITGB5 [ SEEK ]   ITGB5 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3693
GTEX Portal (Tissue expression)ITGB5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18084
Splice isoforms : SwissVarP18084
PhosPhoSitePlusP18084
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)Integin_beta_N    Integrin_beta-5    Integrin_bsu    Integrin_bsu_cyt_dom    Integrin_bsu_tail    Integrin_bsu_VWA    Integrin_dom    PSI    VWF_A   
Domain families : Pfam (Sanger)Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam08725    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)INB (SM00187)  Integrin_b_cyt (SM01241)  Integrin_B_tail (SM01242)  PSI (SM00423)  VWA (SM00327)  
Conserved Domain (NCBI)ITGB5
DMDM Disease mutations3693
Blocks (Seattle)ITGB5
SuperfamilyP18084
Human Protein AtlasENSG00000082781
Peptide AtlasP18084
HPRD00949
IPIIPI00029741   IPI00796872   IPI00979608   IPI00946402   IPI00789162   
Protein Interaction databases
DIP (DOE-UCLA)P18084
IntAct (EBI)P18084
FunCoupENSG00000082781
BioGRIDITGB5
STRING (EMBL)ITGB5
ZODIACITGB5
Ontologies - Pathways
QuickGOP18084
Ontology : AmiGOvirus receptor activity  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  plasma membrane  focal adhesion  muscle contraction  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  cell surface  extracellular matrix organization  integrin alphav-beta5 complex  endodermal cell differentiation  stress fiber assembly  receptor complex  phagocytic vesicle  viral entry into host cell  extracellular exosome  epithelial cell-cell adhesion  
Ontology : EGO-EBIvirus receptor activity  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  protein binding  plasma membrane  focal adhesion  muscle contraction  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  cell surface  extracellular matrix organization  integrin alphav-beta5 complex  endodermal cell differentiation  stress fiber assembly  receptor complex  phagocytic vesicle  viral entry into host cell  extracellular exosome  epithelial cell-cell adhesion  
Pathways : KEGG   
NDEx NetworkITGB5
Atlas of Cancer Signalling NetworkITGB5
Wikipedia pathwaysITGB5
Orthology - Evolution
OrthoDB3693
GeneTree (enSembl)ENSG00000082781
Phylogenetic Trees/Animal Genes : TreeFamITGB5
HOVERGENP18084
HOGENOMP18084
Homologs : HomoloGeneITGB5
Homology/Alignments : Family Browser (UCSC)ITGB5
Gene fusions - Rearrangements
Fusion : MitelmanITGB5/PARP14 [3q21.2/3q21.1]  
Fusion : MitelmanNCOR2/ITGB5 [12q24.31/3q21.2]  [t(3;12)(q21;q24)]  
Fusion: TCGAITGB5 3q21.2 PARP14 3q21.1 BRCA
Fusion: TCGANCOR2 12q24.31 ITGB5 3q21.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB5
dbVarITGB5
ClinVarITGB5
1000_GenomesITGB5 
Exome Variant ServerITGB5
ExAC (Exome Aggregation Consortium)ITGB5 (select the gene name)
Genetic variants : HAPMAP3693
Genomic Variants (DGV)ITGB5 [DGVbeta]
DECIPHERITGB5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB5 
Mutations
ICGC Data PortalITGB5 
TCGA Data PortalITGB5 
Broad Tumor PortalITGB5
OASIS PortalITGB5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB5
DgiDB (Drug Gene Interaction Database)ITGB5
DoCM (Curated mutations)ITGB5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB5 (select a term)
intoGenITGB5
Cancer3DITGB5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147561   
Orphanet
MedgenITGB5
Genetic Testing Registry ITGB5
NextProtP18084 [Medical]
TSGene3693
GENETestsITGB5
Huge Navigator ITGB5 [HugePedia]
snp3D : Map Gene to Disease3693
BioCentury BCIQITGB5
ClinGenITGB5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3693
Chemical/Pharm GKB GenePA29959
Clinical trialITGB5
Miscellaneous
canSAR (ICR)ITGB5 (select the gene name)
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB5
EVEXITGB5
GoPubMedITGB5
iHOPITGB5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:20:54 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.