ITGB6 (integrin subunit beta 6)

2003-08-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
AI1H
FUSION GENES

Other Information

Locus ID:

NCBI: 3694
MIM: 147558
HGNC: 6161
Ensembl: ENSG00000115221

Variants:

dbSNP: 3694
ClinVar: 3694
TCGA: ENSG00000115221
COSMIC: ITGB6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115221ENST00000283249P18564
ENSG00000115221ENST00000409583F8WBJ8
ENSG00000115221ENST00000409872P18564
ENSG00000115221ENST00000409967P18564
ENSG00000115221ENST00000428609E9PEE8
ENSG00000115221ENST00000620391A0A087WXP3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126347872003Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.154
204184892010Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.105
199201742009Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.65
174381342007Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6.60
269011522016Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.59
182218192008Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies.56
281174472017Force interacts with macromolecular structure in activation of TGF-β.43
243672602013αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.42

Citation

Dessen P

ITGB6 (integrin subunit beta 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41022/itgb6