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ITGB6 (integrin subunit beta 6)

Identity

Alias (NCBI)AI1H
HGNC (Hugo) ITGB6
HGNC Previous nameintegrin, beta 6
LocusID (NCBI) 3694
Atlas_Id 41022
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 160099671 and ends at 160200272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB6 (2q24.2) / RBMS1 (2q24.2)ITGB6 (2q24.2) / TANK (2q24.2)PLA2R1 (2q24.2) / ITGB6 (2q24.2)
STK39 (2q24.3) / ITGB6 (2q24.2)ITGB6 2q24.2 / RBMS1 2q24.2PLA2R1 2q24.2 / ITGB6 2q24.2
STK39 2q24.3 / ITGB6 2q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ITGB6   6161
Cards
Entrez_Gene (NCBI)ITGB6    integrin subunit beta 6
AliasesAI1H
GeneCards (Weizmann)ITGB6
Ensembl hg19 (Hinxton)ENSG00000115221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115221 [Gene_View]  ENSG00000115221 [Sequence]  chr2:160099671-160200272 [Contig_View]  ITGB6 [Vega]
ICGC DataPortalENSG00000115221
TCGA cBioPortalITGB6
AceView (NCBI)ITGB6
Genatlas (Paris)ITGB6
SOURCE (Princeton)ITGB6
Genetics Home Reference (NIH)ITGB6
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB6  -     chr2:160099671-160200272 -  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB6  -     2q24.2   [Description]    (hg19-Feb_2009)
GoldenPathITGB6 - 2q24.2 [CytoView hg19]  ITGB6 - 2q24.2 [CytoView hg38]
ImmunoBaseENSG00000115221
Genome Data Viewer NCBIITGB6 [Mapview hg19]  
OMIM147558   616221   
Gene and transcription
Genbank (Entrez)AI264144 AK026736 AK290300 AK304203 AK313944
RefSeq transcript (Entrez)NM_000888 NM_001282353 NM_001282354 NM_001282355 NM_001282388 NM_001282389 NM_001282390
Consensus coding sequences : CCDS (NCBI)ITGB6
Gene ExpressionITGB6 [ NCBI-GEO ]   ITGB6 [ EBI - ARRAY_EXPRESS ]   ITGB6 [ SEEK ]   ITGB6 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB6 [ Firebrowse - Broad ]
GenevisibleExpression of ITGB6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3694
GTEX Portal (Tissue expression)ITGB6
Human Protein AtlasENSG00000115221-ITGB6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18564   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18564  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18564
PhosPhoSitePlusP18564
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    I-EGF_1    Integrin_beta_N    Integrin_bsu    Integrin_bsu-6    Integrin_bsu_cyt_dom    Integrin_bsu_tail    Integrin_bsu_tail_dom_sf    Integrin_bsu_VWA    Integrin_dom_sf    PSI    vWFA_dom_sf   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    I-EGF_1 (PF18372)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam07974    pfam18372    pfam08725    pfam07965    pfam00362    pfam17205   
Domain families : Smart (EMBL)INB (SM00187)  Integrin_b_cyt (SM01241)  Integrin_B_tail (SM01242)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB6
PDB (RSDB)1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
PDB Europe1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
PDB (PDBSum)1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
PDB (IMB)1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
Structural Biology KnowledgeBase1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
SCOP (Structural Classification of Proteins)1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
CATH (Classification of proteins structures)1LH9    4UM8    4UM9    5FFG    5FFO    5NEM    5NER    5NET    5NEU   
SuperfamilyP18564
AlphaFold pdb e-kbP18564   
Human Protein Atlas [tissue]ENSG00000115221-ITGB6 [tissue]
HPRD00947
Protein Interaction databases
DIP (DOE-UCLA)P18564
IntAct (EBI)P18564
BioGRIDITGB6
STRING (EMBL)ITGB6
ZODIACITGB6
Ontologies - Pathways
QuickGOP18564
Ontology : AmiGOcell morphogenesis  virus receptor activity  integrin binding  protein binding  nucleoplasm  centrosome  plasma membrane  focal adhesion  focal adhesion  inflammatory response  immune response  cell adhesion  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  integrin complex  integrin complex  response to virus  external side of plasma membrane  cell surface  cell migration  cell junction  extracellular matrix organization  cell adhesion mediated by integrin  cell adhesion mediated by integrin  integrin alphav-beta6 complex  integrin alphav-beta6 complex  signaling receptor activity  wound healing  surfactant homeostasis  receptor complex  skin development  viral entry into host cell  lung alveolus development  phospholipid homeostasis  hard palate development  bone development  SMAD protein signal transduction  bronchiole development  Langerhans cell differentiation  enamel mineralization  cellular response to ionizing radiation  transforming growth factor beta production  regulation of transforming growth factor beta activation  
Ontology : EGO-EBIcell morphogenesis  virus receptor activity  integrin binding  protein binding  nucleoplasm  centrosome  plasma membrane  focal adhesion  focal adhesion  inflammatory response  immune response  cell adhesion  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  integrin complex  integrin complex  response to virus  external side of plasma membrane  cell surface  cell migration  cell junction  extracellular matrix organization  cell adhesion mediated by integrin  cell adhesion mediated by integrin  integrin alphav-beta6 complex  integrin alphav-beta6 complex  signaling receptor activity  wound healing  surfactant homeostasis  receptor complex  skin development  viral entry into host cell  lung alveolus development  phospholipid homeostasis  hard palate development  bone development  SMAD protein signal transduction  bronchiole development  Langerhans cell differentiation  enamel mineralization  cellular response to ionizing radiation  transforming growth factor beta production  regulation of transforming growth factor beta activation  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB6
Atlas of Cancer Signalling NetworkITGB6
Wikipedia pathwaysITGB6
Orthology - Evolution
OrthoDB3694
GeneTree (enSembl)ENSG00000115221
Phylogenetic Trees/Animal Genes : TreeFamITGB6
Homologs : HomoloGeneITGB6
Homology/Alignments : Family Browser (UCSC)ITGB6
Gene fusions - Rearrangements
Fusion : MitelmanITGB6/RBMS1 [2q24.2/2q24.2]  
Fusion : MitelmanPLA2R1/ITGB6 [2q24.2/2q24.2]  
Fusion : MitelmanSTK39/ITGB6 [2q24.3/2q24.2]  
Fusion Cancer (Beijing)ITGB6 [2q24.2]  -  TANK [2q24.2]  [FUSC000290]
Fusion : QuiverITGB6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB6
dbVarITGB6
ClinVarITGB6
MonarchITGB6
1000_GenomesITGB6 
Exome Variant ServerITGB6
GNOMAD BrowserENSG00000115221
Varsome BrowserITGB6
ACMGITGB6 variants
VarityP18564
Genomic Variants (DGV)ITGB6 [DGVbeta]
DECIPHERITGB6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB6 
Mutations
ICGC Data PortalITGB6 
TCGA Data PortalITGB6 
Broad Tumor PortalITGB6
OASIS PortalITGB6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGB6
Mutations and Diseases : HGMDITGB6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaITGB6
DgiDB (Drug Gene Interaction Database)ITGB6
DoCM (Curated mutations)ITGB6
CIViC (Clinical Interpretations of Variants in Cancer)ITGB6
Cancer3DITGB6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147558    616221   
Orphanet14605    14604   
DisGeNETITGB6
MedgenITGB6
Genetic Testing Registry ITGB6
NextProtP18564 [Medical]
GENETestsITGB6
Target ValidationITGB6
Huge Navigator ITGB6 [HugePedia]
ClinGenITGB6
Clinical trials, drugs, therapy
MyCancerGenomeITGB6
Protein Interactions : CTDITGB6
Pharm GKB GenePA29960
PharosP18564
Clinical trialITGB6
Miscellaneous
canSAR (ICR)ITGB6
HarmonizomeITGB6
DataMed IndexITGB6
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXITGB6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:14:21 CEST 2021

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