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ITGB6 (integrin subunit beta 6)

Identity

Alias_namesintegrin
Other aliasAI1H
HGNC (Hugo) ITGB6
LocusID (NCBI) 3694
Atlas_Id 41022
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 160956177 and ends at 161056824 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ITGB6 (2q24.2) / RBMS1 (2q24.2)ITGB6 (2q24.2) / TANK (2q24.2)PLA2R1 (2q24.2) / ITGB6 (2q24.2)
STK39 (2q24.3) / ITGB6 (2q24.2)ITGB6 2q24.2 / RBMS1 2q24.2PLA2R1 2q24.2 / ITGB6 2q24.2
STK39 2q24.3 / ITGB6 2q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGB6   6161
Cards
Entrez_Gene (NCBI)ITGB6  3694  integrin subunit beta 6
AliasesAI1H
GeneCards (Weizmann)ITGB6
Ensembl hg19 (Hinxton)ENSG00000115221 [Gene_View]  chr2:160956177-161056824 [Contig_View]  ITGB6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115221 [Gene_View]  chr2:160956177-161056824 [Contig_View]  ITGB6 [Vega]
ICGC DataPortalENSG00000115221
TCGA cBioPortalITGB6
AceView (NCBI)ITGB6
Genatlas (Paris)ITGB6
WikiGenes3694
SOURCE (Princeton)ITGB6
Genetics Home Reference (NIH)ITGB6
Genomic and cartography
GoldenPath hg19 (UCSC)ITGB6  -     chr2:160956177-161056824 -  2q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGB6  -     2q24.2   [Description]    (hg38-Dec_2013)
EnsemblITGB6 - 2q24.2 [CytoView hg19]  ITGB6 - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIITGB6 [Mapview hg19]  ITGB6 [Mapview hg38]
OMIM147558   616221   
Gene and transcription
Genbank (Entrez)AI264144 AK026736 AK290300 AK304203 AK313944
RefSeq transcript (Entrez)NM_000888 NM_001282353 NM_001282354 NM_001282355 NM_001282388 NM_001282389 NM_001282390
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_042041 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)ITGB6
Cluster EST : UnigeneHs.470399 [ NCBI ]
CGAP (NCI)Hs.470399
Alternative Splicing GalleryENSG00000115221
Gene ExpressionITGB6 [ NCBI-GEO ]   ITGB6 [ EBI - ARRAY_EXPRESS ]   ITGB6 [ SEEK ]   ITGB6 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3694
GTEX Portal (Tissue expression)ITGB6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18564   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18564  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18564
Splice isoforms : SwissVarP18564
PhosPhoSitePlusP18564
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integrin_bsu    Integrin_bsu-6    Integrin_bsu_cyt_dom    Integrin_bsu_N    Integrin_bsu_tail    Integrin_dom    Plexin-like_fold    VWF_A   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_B_tail (PF07965)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam07965    pfam00362   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
Conserved Domain (NCBI)ITGB6
DMDM Disease mutations3694
Blocks (Seattle)ITGB6
PDB (SRS)1LH9    4UM8    4UM9   
PDB (PDBSum)1LH9    4UM8    4UM9   
PDB (IMB)1LH9    4UM8    4UM9   
PDB (RSDB)1LH9    4UM8    4UM9   
Structural Biology KnowledgeBase1LH9    4UM8    4UM9   
SCOP (Structural Classification of Proteins)1LH9    4UM8    4UM9   
CATH (Classification of proteins structures)1LH9    4UM8    4UM9   
SuperfamilyP18564
Human Protein AtlasENSG00000115221
Peptide AtlasP18564
HPRD00947
IPIIPI00000151   IPI00917985   IPI00917837   IPI00926712   
Protein Interaction databases
DIP (DOE-UCLA)P18564
IntAct (EBI)P18564
FunCoupENSG00000115221
BioGRIDITGB6
STRING (EMBL)ITGB6
ZODIACITGB6
Ontologies - Pathways
QuickGOP18564
Ontology : AmiGOvirus receptor activity  integrin binding  plasma membrane  inflammatory response  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  external side of plasma membrane  extracellular matrix organization  receptor complex  viral entry into host cell  extracellular exosome  
Ontology : EGO-EBIvirus receptor activity  integrin binding  plasma membrane  inflammatory response  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  external side of plasma membrane  extracellular matrix organization  receptor complex  viral entry into host cell  extracellular exosome  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB6
Atlas of Cancer Signalling NetworkITGB6
Wikipedia pathwaysITGB6
Orthology - Evolution
OrthoDB3694
GeneTree (enSembl)ENSG00000115221
Phylogenetic Trees/Animal Genes : TreeFamITGB6
HOVERGENP18564
HOGENOMP18564
Homologs : HomoloGeneITGB6
Homology/Alignments : Family Browser (UCSC)ITGB6
Gene fusions - Rearrangements
Fusion : MitelmanITGB6/RBMS1 [2q24.2/2q24.2]  
Fusion : MitelmanPLA2R1/ITGB6 [2q24.2/2q24.2]  [t(2;2)(q24;q24)]  
Fusion : MitelmanSTK39/ITGB6 [2q24.3/2q24.2]  [t(2;2)(q24;q24)]  
Fusion: TCGAITGB6 2q24.2 RBMS1 2q24.2 BLCA BRCA
Fusion: TCGAPLA2R1 2q24.2 ITGB6 2q24.2 HNSC
Fusion: TCGASTK39 2q24.3 ITGB6 2q24.2 BRCA
Fusion Cancer (Beijing)ITGB6 [2q24.2]  -  TANK [2q24.2]  [FUSC000290]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB6
dbVarITGB6
ClinVarITGB6
1000_GenomesITGB6 
Exome Variant ServerITGB6
ExAC (Exome Aggregation Consortium)ITGB6 (select the gene name)
Genetic variants : HAPMAP3694
Genomic Variants (DGV)ITGB6 [DGVbeta]
DECIPHER (Syndromes)2:160956177-161056824  ENSG00000115221
CONAN: Copy Number AnalysisITGB6 
Mutations
ICGC Data PortalITGB6 
TCGA Data PortalITGB6 
Broad Tumor PortalITGB6
OASIS PortalITGB6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB6
DgiDB (Drug Gene Interaction Database)ITGB6
DoCM (Curated mutations)ITGB6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB6 (select a term)
intoGenITGB6
Cancer3DITGB6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147558    616221   
Orphanet14605    14604   
MedgenITGB6
Genetic Testing Registry ITGB6
NextProtP18564 [Medical]
TSGene3694
GENETestsITGB6
Huge Navigator ITGB6 [HugePedia]
snp3D : Map Gene to Disease3694
BioCentury BCIQITGB6
ClinGenITGB6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3694
Chemical/Pharm GKB GenePA29960
Clinical trialITGB6
Miscellaneous
canSAR (ICR)ITGB6 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB6
EVEXITGB6
GoPubMedITGB6
iHOPITGB6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:05:36 CEST 2017

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