Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ITGB7 (integrin subunit beta 7)

Identity

Alias_namesintegrin
Other alias-
HGNC (Hugo) ITGB7
LocusID (NCBI) 3695
Atlas_Id 41023
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53585102 and ends at 53601091 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CSAD (12q13.13) / ITGB7 (12q13.13)SFPQ (16q24.1) / ITGB7 (12q13.13)CSAD 12q13.13 / ITGB7 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITGB7   6162
Cards
Entrez_Gene (NCBI)ITGB7  3695  integrin subunit beta 7
Aliases
GeneCards (Weizmann)ITGB7
Ensembl hg19 (Hinxton)ENSG00000139626 [Gene_View]  chr12:53585102-53601091 [Contig_View]  ITGB7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000139626 [Gene_View]  chr12:53585102-53601091 [Contig_View]  ITGB7 [Vega]
ICGC DataPortalENSG00000139626
TCGA cBioPortalITGB7
AceView (NCBI)ITGB7
Genatlas (Paris)ITGB7
WikiGenes3695
SOURCE (Princeton)ITGB7
Genetics Home Reference (NIH)ITGB7
Genomic and cartography
GoldenPath hg19 (UCSC)ITGB7  -     chr12:53585102-53601091 -  12q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITGB7  -     12q13.13   [Description]    (hg38-Dec_2013)
EnsemblITGB7 - 12q13.13 [CytoView hg19]  ITGB7 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIITGB7 [Mapview hg19]  ITGB7 [Mapview hg38]
OMIM147559   
Gene and transcription
Genbank (Entrez)AI804573 AK298239 AK300960 AK301523 AK311703
RefSeq transcript (Entrez)NM_000889
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)ITGB7
Cluster EST : UnigeneHs.654470 [ NCBI ]
CGAP (NCI)Hs.654470
Alternative Splicing GalleryENSG00000139626
Gene ExpressionITGB7 [ NCBI-GEO ]   ITGB7 [ EBI - ARRAY_EXPRESS ]   ITGB7 [ SEEK ]   ITGB7 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3695
GTEX Portal (Tissue expression)ITGB7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26010   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26010  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26010
Splice isoforms : SwissVarP26010
PhosPhoSitePlusP26010
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF_extracell    Integrin_bsu    Integrin_bsu-7    Integrin_bsu_cyt_dom    Integrin_bsu_N    Integrin_bsu_tail    Integrin_dom    Plexin-like_fold    VWF_A   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_b_cyt (PF08725)    Integrin_beta (PF00362)   
Domain families : Pfam (NCBI)pfam07974    pfam08725    pfam00362   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  VWA (SM00327)  
Conserved Domain (NCBI)ITGB7
DMDM Disease mutations3695
Blocks (Seattle)ITGB7
PDB (SRS)2BRQ    3V4P    3V4V   
PDB (PDBSum)2BRQ    3V4P    3V4V   
PDB (IMB)2BRQ    3V4P    3V4V   
PDB (RSDB)2BRQ    3V4P    3V4V   
Structural Biology KnowledgeBase2BRQ    3V4P    3V4V   
SCOP (Structural Classification of Proteins)2BRQ    3V4P    3V4V   
CATH (Classification of proteins structures)2BRQ    3V4P    3V4V   
SuperfamilyP26010
Human Protein AtlasENSG00000139626
Peptide AtlasP26010
HPRD00948
IPIIPI00297880   IPI00412656   IPI00922174   IPI00797992   IPI01025262   
Protein Interaction databases
DIP (DOE-UCLA)P26010
IntAct (EBI)P26010
FunCoupENSG00000139626
BioGRIDITGB7
STRING (EMBL)ITGB7
ZODIACITGB7
Ontologies - Pathways
QuickGOP26010
Ontology : AmiGOvirus receptor activity  cell-matrix adhesion involved in ameboidal cell migration  protein binding  plasma membrane  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  cell surface  membrane  extracellular matrix organization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alpha4-beta7 complex  receptor clustering  receptor complex  viral entry into host cell  metal ion binding  regulation of immune response  cell adhesion molecule binding  leukocyte tethering or rolling  extracellular exosome  T cell migration  
Ontology : EGO-EBIvirus receptor activity  cell-matrix adhesion involved in ameboidal cell migration  protein binding  plasma membrane  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  cell surface  membrane  extracellular matrix organization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  integrin alpha4-beta7 complex  receptor clustering  receptor complex  viral entry into host cell  metal ion binding  regulation of immune response  cell adhesion molecule binding  leukocyte tethering or rolling  extracellular exosome  T cell migration  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Cell adhesion molecules (CAMs)    Intestinal immune network for IgA production    Regulation of actin cytoskeleton    Transcriptional misregulation in cancer    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB7
Atlas of Cancer Signalling NetworkITGB7
Wikipedia pathwaysITGB7
Orthology - Evolution
OrthoDB3695
GeneTree (enSembl)ENSG00000139626
Phylogenetic Trees/Animal Genes : TreeFamITGB7
HOVERGENP26010
HOGENOMP26010
Homologs : HomoloGeneITGB7
Homology/Alignments : Family Browser (UCSC)ITGB7
Gene fusions - Rearrangements
Fusion : MitelmanCSAD/ITGB7 [12q13.13/12q13.13]  [t(12;12)(q13;q13)]  
Fusion: TCGACSAD 12q13.13 ITGB7 12q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB7
dbVarITGB7
ClinVarITGB7
1000_GenomesITGB7 
Exome Variant ServerITGB7
ExAC (Exome Aggregation Consortium)ITGB7 (select the gene name)
Genetic variants : HAPMAP3695
Genomic Variants (DGV)ITGB7 [DGVbeta]
DECIPHER (Syndromes)12:53585102-53601091  ENSG00000139626
CONAN: Copy Number AnalysisITGB7 
Mutations
ICGC Data PortalITGB7 
TCGA Data PortalITGB7 
Broad Tumor PortalITGB7
OASIS PortalITGB7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITGB7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB7
DgiDB (Drug Gene Interaction Database)ITGB7
DoCM (Curated mutations)ITGB7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB7 (select a term)
intoGenITGB7
Cancer3DITGB7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147559   
Orphanet
MedgenITGB7
Genetic Testing Registry ITGB7
NextProtP26010 [Medical]
TSGene3695
GENETestsITGB7
Huge Navigator ITGB7 [HugePedia]
snp3D : Map Gene to Disease3695
BioCentury BCIQITGB7
ClinGenITGB7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3695
Chemical/Pharm GKB GenePA29961
Clinical trialITGB7
Miscellaneous
canSAR (ICR)ITGB7 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB7
EVEXITGB7
GoPubMedITGB7
iHOPITGB7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:11:14 CET 2017

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