Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ITGB8 (integrin subunit beta 8)

Identity

Alias_namesintegrin, beta 8
Other alias-
HGNC (Hugo) ITGB8
LocusID (NCBI) 3696
Atlas_Id 41024
Location 7p21.1  [Link to chromosome band 7p21]
Location_base_pair Starts at 20331102 and ends at 20415759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB8 (7p21.1) / ITGB8 (7p21.1)ITGB8 (7p21.1) / LOC440600 (1p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ITGB8   6163
Cards
Entrez_Gene (NCBI)ITGB8  3696  integrin subunit beta 8
Aliases
GeneCards (Weizmann)ITGB8
Ensembl hg19 (Hinxton)ENSG00000105855 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105855 [Gene_View]  ENSG00000105855 [Sequence]  chr7:20331102-20415759 [Contig_View]  ITGB8 [Vega]
ICGC DataPortalENSG00000105855
TCGA cBioPortalITGB8
AceView (NCBI)ITGB8
Genatlas (Paris)ITGB8
WikiGenes3696
SOURCE (Princeton)ITGB8
Genetics Home Reference (NIH)ITGB8
Genomic and cartography
GoldenPath hg38 (UCSC)ITGB8  -     chr7:20331102-20415759 +  7p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITGB8  -     7p21.1   [Description]    (hg19-Feb_2009)
GoldenPathITGB8 - 7p21.1 [CytoView hg19]  ITGB8 - 7p21.1 [CytoView hg38]
ImmunoBaseENSG00000105855
Mapping of homologs : NCBIITGB8 [Mapview hg19]  ITGB8 [Mapview hg38]
OMIM604160   
Gene and transcription
Genbank (Entrez)AB209429 AK295044 AW516961 BC002630 BC038209
RefSeq transcript (Entrez)NM_002214
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITGB8
Alternative Splicing GalleryENSG00000105855
Gene ExpressionITGB8 [ NCBI-GEO ]   ITGB8 [ EBI - ARRAY_EXPRESS ]   ITGB8 [ SEEK ]   ITGB8 [ MEM ]
Gene Expression Viewer (FireBrowse)ITGB8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3696
GTEX Portal (Tissue expression)ITGB8
Human Protein AtlasENSG00000105855-ITGB8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26012   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26012  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26012
Splice isoforms : SwissVarP26012
PhosPhoSitePlusP26012
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    INTEGRIN_BETA (PS00243)   
Domains : Interpro (EBI)EGF-like_CS    EGF_extracell    Integrin_beta_N    Integrin_bsu    Integrin_bsu-8    Integrin_bsu_VWA    Integrin_dom_sf    PSI    vWFA_dom_sf   
Domain families : Pfam (Sanger)EGF_2 (PF07974)    Integrin_beta (PF00362)    PSI_integrin (PF17205)   
Domain families : Pfam (NCBI)pfam07974    pfam00362    pfam17205   
Domain families : Smart (EMBL)INB (SM00187)  PSI (SM00423)  
Conserved Domain (NCBI)ITGB8
DMDM Disease mutations3696
Blocks (Seattle)ITGB8
PDB (RSDB)6DJP   
PDB Europe6DJP   
PDB (PDBSum)6DJP   
PDB (IMB)6DJP   
Structural Biology KnowledgeBase6DJP   
SCOP (Structural Classification of Proteins)6DJP   
CATH (Classification of proteins structures)6DJP   
SuperfamilyP26012
Human Protein Atlas [tissue]ENSG00000105855-ITGB8 [tissue]
Peptide AtlasP26012
HPRD05001
IPIIPI00029533   IPI01015804   IPI00555554   
Protein Interaction databases
DIP (DOE-UCLA)P26012
IntAct (EBI)P26012
FunCoupENSG00000105855
BioGRIDITGB8
STRING (EMBL)ITGB8
ZODIACITGB8
Ontologies - Pathways
QuickGOP26012
Ontology : AmiGOvasculogenesis  ganglioside metabolic process  integrin binding  plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  cell surface  cell surface  positive regulation of gene expression  negative regulation of gene expression  cell migration  extracellular matrix organization  cell adhesion mediated by integrin  integrin alphav-beta8 complex  signaling receptor activity  positive regulation of angiogenesis  cartilage development  placenta blood vessel development  extracellular exosome  regulation of transforming growth factor beta activation  extracellular matrix protein binding  
Ontology : EGO-EBIvasculogenesis  ganglioside metabolic process  integrin binding  plasma membrane  focal adhesion  cell adhesion  cell-matrix adhesion  integrin-mediated signaling pathway  integrin complex  integrin complex  cell surface  cell surface  positive regulation of gene expression  negative regulation of gene expression  cell migration  extracellular matrix organization  cell adhesion mediated by integrin  integrin alphav-beta8 complex  signaling receptor activity  positive regulation of angiogenesis  cartilage development  placenta blood vessel development  extracellular exosome  regulation of transforming growth factor beta activation  extracellular matrix protein binding  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Cell adhesion molecules (CAMs)    Regulation of actin cytoskeleton    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy   
NDEx NetworkITGB8
Atlas of Cancer Signalling NetworkITGB8
Wikipedia pathwaysITGB8
Orthology - Evolution
OrthoDB3696
GeneTree (enSembl)ENSG00000105855
Phylogenetic Trees/Animal Genes : TreeFamITGB8
HOGENOMP26012
Homologs : HomoloGeneITGB8
Homology/Alignments : Family Browser (UCSC)ITGB8
Gene fusions - Rearrangements
Fusion : QuiverITGB8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITGB8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITGB8
dbVarITGB8
ClinVarITGB8
1000_GenomesITGB8 
Exome Variant ServerITGB8
ExAC (Exome Aggregation Consortium)ENSG00000105855
GNOMAD BrowserENSG00000105855
Varsome BrowserITGB8
Genetic variants : HAPMAP3696
Genomic Variants (DGV)ITGB8 [DGVbeta]
DECIPHERITGB8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITGB8 
Mutations
ICGC Data PortalITGB8 
TCGA Data PortalITGB8 
Broad Tumor PortalITGB8
OASIS PortalITGB8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITGB8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITGB8
Mutations and Diseases : HGMDITGB8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITGB8
DgiDB (Drug Gene Interaction Database)ITGB8
DoCM (Curated mutations)ITGB8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITGB8 (select a term)
intoGenITGB8
Cancer3DITGB8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604160   
Orphanet
DisGeNETITGB8
MedgenITGB8
Genetic Testing Registry ITGB8
NextProtP26012 [Medical]
TSGene3696
GENETestsITGB8
Target ValidationITGB8
Huge Navigator ITGB8 [HugePedia]
snp3D : Map Gene to Disease3696
BioCentury BCIQITGB8
ClinGenITGB8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3696
Chemical/Pharm GKB GenePA29962
Clinical trialITGB8
Miscellaneous
canSAR (ICR)ITGB8 (select the gene name)
HarmonizomeITGB8
DataMed IndexITGB8
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITGB8
EVEXITGB8
GoPubMedITGB8
iHOPITGB8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Mar 11 19:12:36 CET 2020
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