ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1)

2007-02-01  

Identity

HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
H1P,IATIH,IGHEP1,ITI-HC1,ITIH,SHAP

Other Information

Locus ID:

NCBI: 3697
MIM: 147270
HGNC: 6166
Ensembl: ENSG00000055957

Variants:

dbSNP: 3697
ClinVar: 3697
TCGA: ENSG00000055957
COSMIC: ITIH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000055957ENST00000273283P19827
ENSG00000055957ENST00000405128B5MCP1
ENSG00000055957ENST00000428133H7C0N0
ENSG00000055957ENST00000480409F8WAS2
ENSG00000055957ENST00000484844H7C5I0
ENSG00000055957ENST00000537050P19827

Expression (GTEx)

0
100
200
300
400
500
600

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194169212009Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.114
182262092008Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.54
176752952007PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion.52
240056732013Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking.26
193675812010Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.13
118077862002Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains.10
276794892016Thrombin Cleavage of Inter-α-inhibitor Heavy Chain 1 Regulates Leukocyte Binding to an Inflammatory Hyaluronan Matrix.8
219397892011Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.5
243893982014ITIH family genes confer risk to schizophrenia and major depressive disorder in the Han Chinese population.3
267284542016The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.2

Citation

Dessen P

ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46281/itih1