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ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2)

Identity

Alias (NCBI)H2P
SHAP
HGNC (Hugo) ITIH2
HGNC Alias symbH2P
HGNC Previous nameinter-alpha (globulin) inhibitor, H2 polypeptide
LocusID (NCBI) 3698
Atlas_Id 50300
Location 10p14  [Link to chromosome band 10p14]
Location_base_pair Starts at 7703316 and ends at 7749520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ITIH2   6167
Cards
Entrez_Gene (NCBI)ITIH2    inter-alpha-trypsin inhibitor heavy chain 2
AliasesH2P; SHAP
GeneCards (Weizmann)ITIH2
Ensembl hg19 (Hinxton)ENSG00000151655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151655 [Gene_View]  ENSG00000151655 [Sequence]  chr10:7703316-7749520 [Contig_View]  ITIH2 [Vega]
ICGC DataPortalENSG00000151655
TCGA cBioPortalITIH2
AceView (NCBI)ITIH2
Genatlas (Paris)ITIH2
SOURCE (Princeton)ITIH2
Genetics Home Reference (NIH)ITIH2
Genomic and cartography
GoldenPath hg38 (UCSC)ITIH2  -     chr10:7703316-7749520 +  10p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITIH2  -     10p14   [Description]    (hg19-Feb_2009)
GoldenPathITIH2 - 10p14 [CytoView hg19]  ITIH2 - 10p14 [CytoView hg38]
ImmunoBaseENSG00000151655
Genome Data Viewer NCBIITIH2 [Mapview hg19]  
OMIM146640   
Gene and transcription
Genbank (Entrez)AA406494 AK225277 AK225329 AK291379 AK297334
RefSeq transcript (Entrez)NM_002216
Consensus coding sequences : CCDS (NCBI)ITIH2
Gene ExpressionITIH2 [ NCBI-GEO ]   ITIH2 [ EBI - ARRAY_EXPRESS ]   ITIH2 [ SEEK ]   ITIH2 [ MEM ]
Gene Expression Viewer (FireBrowse)ITIH2 [ Firebrowse - Broad ]
GenevisibleExpression of ITIH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3698
GTEX Portal (Tissue expression)ITIH2
Human Protein AtlasENSG00000151655-ITIH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19823   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19823  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19823
PhosPhoSitePlusP19823
Domaine pattern : Prosite (Expaxy)VIT (PS51468)    VWFA (PS50234)   
Domains : Interpro (EBI)ITI_HC_C    VIT    VWF_A    vWFA_dom_sf   
Domain families : Pfam (Sanger)ITI_HC_C (PF06668)    VIT (PF08487)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam06668    pfam08487    pfam00092   
Domain families : Smart (EMBL)VIT (SM00609)  VWA (SM00327)  
Conserved Domain (NCBI)ITIH2
SuperfamilyP19823
AlphaFold pdb e-kbP19823   
Human Protein Atlas [tissue]ENSG00000151655-ITIH2 [tissue]
HPRD00890
Protein Interaction databases
DIP (DOE-UCLA)P19823
IntAct (EBI)P19823
BioGRIDITIH2
STRING (EMBL)ITIH2
ZODIACITIH2
Ontologies - Pathways
QuickGOP19823
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  endoplasmic reticulum lumen  negative regulation of endopeptidase activity  hyaluronan metabolic process  post-translational protein modification  cellular protein metabolic process  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  extracellular region  endoplasmic reticulum lumen  negative regulation of endopeptidase activity  hyaluronan metabolic process  post-translational protein modification  cellular protein metabolic process  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  blood microparticle  
NDEx NetworkITIH2
Atlas of Cancer Signalling NetworkITIH2
Wikipedia pathwaysITIH2
Orthology - Evolution
OrthoDB3698
GeneTree (enSembl)ENSG00000151655
Phylogenetic Trees/Animal Genes : TreeFamITIH2
Homologs : HomoloGeneITIH2
Homology/Alignments : Family Browser (UCSC)ITIH2
Gene fusions - Rearrangements
Fusion : QuiverITIH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITIH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITIH2
dbVarITIH2
ClinVarITIH2
MonarchITIH2
1000_GenomesITIH2 
Exome Variant ServerITIH2
GNOMAD BrowserENSG00000151655
Varsome BrowserITIH2
ACMGITIH2 variants
VarityP19823
Genomic Variants (DGV)ITIH2 [DGVbeta]
DECIPHERITIH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITIH2 
Mutations
ICGC Data PortalITIH2 
TCGA Data PortalITIH2 
Broad Tumor PortalITIH2
OASIS PortalITIH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITIH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITIH2
Mutations and Diseases : HGMDITIH2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaITIH2
DgiDB (Drug Gene Interaction Database)ITIH2
DoCM (Curated mutations)ITIH2
CIViC (Clinical Interpretations of Variants in Cancer)ITIH2
Cancer3DITIH2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146640   
Orphanet
DisGeNETITIH2
MedgenITIH2
Genetic Testing Registry ITIH2
NextProtP19823 [Medical]
GENETestsITIH2
Target ValidationITIH2
Huge Navigator ITIH2 [HugePedia]
ClinGenITIH2
Clinical trials, drugs, therapy
MyCancerGenomeITIH2
Protein Interactions : CTDITIH2
Pharm GKB GenePA29965
PharosP19823
Clinical trialITIH2
Miscellaneous
canSAR (ICR)ITIH2
HarmonizomeITIH2
DataMed IndexITIH2
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXITIH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:22 CEST 2021

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