ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5)

2007-02-01  

Identity

HGNC
LOCATION
10p14
LOCUSID
ALIAS
ITI-HC5,PP14776
FUSION GENES

Other Information

Locus ID:

NCBI: 80760
MIM: 609783
HGNC: 21449
Ensembl: ENSG00000123243

Variants:

dbSNP: 80760
ClinVar: 80760
TCGA: ENSG00000123243
COSMIC: ITIH5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123243ENST00000397145G5E9D8
ENSG00000123243ENST00000397146C9J2H1
ENSG00000123243ENST00000461751H7C5A6
ENSG00000123243ENST00000613909A0A096LP62

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233207512013Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening.38
176530902008The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation.35
202009532010Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.27
226166912012Functional annotation of the human fat cell secretome.24
147445362004ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer.19
242652922014Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours.13
262523522015Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome.13
218528142012ITIH-5 expression in human adipose tissue is increased in obesity.12

Citation

Dessen P

ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43692/itih5