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ITPKB (inositol-trisphosphate 3-kinase B)

Identity

Alias_namesinositol 1
Alias_symbol (synonym)IP3KB
IP3-3KB
Other aliasIP3K
IP3K-B
PIG37
HGNC (Hugo) ITPKB
LocusID (NCBI) 3707
Atlas_Id 41026
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226631690 and ends at 226739175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITPKB (1q42.12) / ITPKB (1q42.12)ITPKB (1q42.12) / ZC3HAV1 (7q34)KANSL3 (2q11.2) / ITPKB (1q42.12)
NFKB1 (4q24) / ITPKB (1q42.12)PNO1 (2p14) / ITPKB (1q42.12)UNC80 (2q34) / ITPKB (1q42.12)
ZC3HAV1 (7q34) / ITPKB (1q42.12)ITPKB 1q42.12 / ZC3HAV1 7q34ZC3HAV1 7q34 / ITPKB 1q42.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;7)(q42;q34) ITPKB/ZC3HAV1
t(1;7)(q42;q34) ZC3HAV1/ITPKB


External links

Nomenclature
HGNC (Hugo)ITPKB   6179
Cards
Entrez_Gene (NCBI)ITPKB  3707  inositol-trisphosphate 3-kinase B
AliasesIP3-3KB; IP3K; IP3K-B; IP3KB; 
PIG37
GeneCards (Weizmann)ITPKB
Ensembl hg19 (Hinxton)ENSG00000143772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143772 [Gene_View]  ENSG00000143772 [Sequence]  chr1:226631690-226739175 [Contig_View]  ITPKB [Vega]
ICGC DataPortalENSG00000143772
TCGA cBioPortalITPKB
AceView (NCBI)ITPKB
Genatlas (Paris)ITPKB
WikiGenes3707
SOURCE (Princeton)ITPKB
Genetics Home Reference (NIH)ITPKB
Genomic and cartography
GoldenPath hg38 (UCSC)ITPKB  -     chr1:226631690-226739175 -  1q42.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITPKB  -     1q42.12   [Description]    (hg19-Feb_2009)
EnsemblITPKB - 1q42.12 [CytoView hg19]  ITPKB - 1q42.12 [CytoView hg38]
Mapping of homologs : NCBIITPKB [Mapview hg19]  ITPKB [Mapview hg38]
OMIM147522   
Gene and transcription
Genbank (Entrez)AJ242780 AK025304 AK095901 AK289700 AK313801
RefSeq transcript (Entrez)NM_002221
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITPKB
Cluster EST : UnigeneHs.690477 [ NCBI ]
CGAP (NCI)Hs.690477
Alternative Splicing GalleryENSG00000143772
Gene ExpressionITPKB [ NCBI-GEO ]   ITPKB [ EBI - ARRAY_EXPRESS ]   ITPKB [ SEEK ]   ITPKB [ MEM ]
Gene Expression Viewer (FireBrowse)ITPKB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3707
GTEX Portal (Tissue expression)ITPKB
Human Protein AtlasENSG00000143772-ITPKB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27987   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27987  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27987
Splice isoforms : SwissVarP27987
Catalytic activity : Enzyme2.7.1.127 [ Enzyme-Expasy ]   2.7.1.1272.7.1.127 [ IntEnz-EBI ]   2.7.1.127 [ BRENDA ]   2.7.1.127 [ KEGG ]   
PhosPhoSitePlusP27987
Domains : Interpro (EBI)IPK   
Domain families : Pfam (Sanger)IPK (PF03770)   
Domain families : Pfam (NCBI)pfam03770   
Conserved Domain (NCBI)ITPKB
DMDM Disease mutations3707
Blocks (Seattle)ITPKB
SuperfamilyP27987
Human Protein Atlas [tissue]ENSG00000143772-ITPKB [tissue]
Peptide AtlasP27987
HPRD00942
IPIIPI00021449   IPI00645189   
Protein Interaction databases
DIP (DOE-UCLA)P27987
IntAct (EBI)P27987
FunCoupENSG00000143772
BioGRIDITPKB
STRING (EMBL)ITPKB
ZODIACITPKB
Ontologies - Pathways
QuickGOP27987
Ontology : AmiGOMAPK cascade  regulation of protein phosphorylation  myeloid cell homeostasis  protein binding  calmodulin binding  ATP binding  nucleus  cytosol  signal transduction  cell surface receptor signaling pathway  inositol-1,4,5-trisphosphate 3-kinase activity  inositol-1,4,5-trisphosphate 3-kinase activity  membrane  inositol trisphosphate metabolic process  inositol phosphate biosynthetic process  negative regulation of neutrophil apoptotic process  common myeloid progenitor cell proliferation  inositol phosphate metabolic process  positive thymic T cell selection  negative regulation of myeloid cell differentiation  positive regulation of Ras protein signal transduction  positive regulation of alpha-beta T cell differentiation  cellular response to calcium ion  
Ontology : EGO-EBIMAPK cascade  regulation of protein phosphorylation  myeloid cell homeostasis  protein binding  calmodulin binding  ATP binding  nucleus  cytosol  signal transduction  cell surface receptor signaling pathway  inositol-1,4,5-trisphosphate 3-kinase activity  inositol-1,4,5-trisphosphate 3-kinase activity  membrane  inositol trisphosphate metabolic process  inositol phosphate biosynthetic process  negative regulation of neutrophil apoptotic process  common myeloid progenitor cell proliferation  inositol phosphate metabolic process  positive thymic T cell selection  negative regulation of myeloid cell differentiation  positive regulation of Ras protein signal transduction  positive regulation of alpha-beta T cell differentiation  cellular response to calcium ion  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system    Calcium signaling pathway   
NDEx NetworkITPKB
Atlas of Cancer Signalling NetworkITPKB
Wikipedia pathwaysITPKB
Orthology - Evolution
OrthoDB3707
GeneTree (enSembl)ENSG00000143772
Phylogenetic Trees/Animal Genes : TreeFamITPKB
HOVERGENP27987
HOGENOMP27987
Homologs : HomoloGeneITPKB
Homology/Alignments : Family Browser (UCSC)ITPKB
Gene fusions - Rearrangements
Fusion : MitelmanITPKB/ZC3HAV1 [1q42.12/7q34]  
Fusion : MitelmanZC3HAV1/ITPKB [7q34/1q42.12]  [t(1;7)(q42;q34)]  
Fusion PortalITPKB 1q42.12 ZC3HAV1 7q34 BRCA
Fusion PortalZC3HAV1 7q34 ITPKB 1q42.12 BRCA
Fusion : QuiverITPKB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITPKB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITPKB
dbVarITPKB
ClinVarITPKB
1000_GenomesITPKB 
Exome Variant ServerITPKB
ExAC (Exome Aggregation Consortium)ENSG00000143772
GNOMAD BrowserENSG00000143772
Genetic variants : HAPMAP3707
Genomic Variants (DGV)ITPKB [DGVbeta]
DECIPHERITPKB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITPKB 
Mutations
ICGC Data PortalITPKB 
TCGA Data PortalITPKB 
Broad Tumor PortalITPKB
OASIS PortalITPKB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITPKB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITPKB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITPKB
DgiDB (Drug Gene Interaction Database)ITPKB
DoCM (Curated mutations)ITPKB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITPKB (select a term)
intoGenITPKB
Cancer3DITPKB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147522   
Orphanet
DisGeNETITPKB
MedgenITPKB
Genetic Testing Registry ITPKB
NextProtP27987 [Medical]
TSGene3707
GENETestsITPKB
Target ValidationITPKB
Huge Navigator ITPKB [HugePedia]
snp3D : Map Gene to Disease3707
BioCentury BCIQITPKB
ClinGenITPKB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3707
Chemical/Pharm GKB GenePA29976
Clinical trialITPKB
Miscellaneous
canSAR (ICR)ITPKB (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITPKB
EVEXITPKB
GoPubMedITPKB
iHOPITPKB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:31:27 CEST 2018

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