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ITPKB (inositol-trisphosphate 3-kinase B)

Identity

Alias (NCBI)IP3-3KB
IP3K
IP3K-B
IP3KB
PIG37
HGNC (Hugo) ITPKB
HGNC Alias symbIP3KB
IP3-3KB
HGNC Previous nameinositol 1,4,5-trisphosphate 3-kinase B
LocusID (NCBI) 3707
Atlas_Id 41026
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226631690 and ends at 226739175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITPKB (1q42.12) / ITPKB (1q42.12)ITPKB (1q42.12) / ZC3HAV1 (7q34)KANSL3 (2q11.2) / ITPKB (1q42.12)
NFKB1 (4q24) / ITPKB (1q42.12)PNO1 (2p14) / ITPKB (1q42.12)UNC80 (2q34) / ITPKB (1q42.12)
ZC3HAV1 (7q34) / ITPKB (1q42.12)ITPKB 1q42.12 / ZC3HAV1 7q34ZC3HAV1 7q34 / ITPKB 1q42.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ITPKB   6179
Cards
Entrez_Gene (NCBI)ITPKB    inositol-trisphosphate 3-kinase B
AliasesIP3-3KB; IP3K; IP3K-B; IP3KB; 
PIG37
GeneCards (Weizmann)ITPKB
Ensembl hg19 (Hinxton)ENSG00000143772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143772 [Gene_View]  ENSG00000143772 [Sequence]  chr1:226631690-226739175 [Contig_View]  ITPKB [Vega]
ICGC DataPortalENSG00000143772
TCGA cBioPortalITPKB
AceView (NCBI)ITPKB
Genatlas (Paris)ITPKB
SOURCE (Princeton)ITPKB
Genetics Home Reference (NIH)ITPKB
Genomic and cartography
GoldenPath hg38 (UCSC)ITPKB  -     chr1:226631690-226739175 -  1q42.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITPKB  -     1q42.12   [Description]    (hg19-Feb_2009)
GoldenPathITPKB - 1q42.12 [CytoView hg19]  ITPKB - 1q42.12 [CytoView hg38]
ImmunoBaseENSG00000143772
Genome Data Viewer NCBIITPKB [Mapview hg19]  
OMIM147522   
Gene and transcription
Genbank (Entrez)AJ242780 AK025304 AK095901 AK289700 AK313801
RefSeq transcript (Entrez)NM_001388404 NM_002221
Consensus coding sequences : CCDS (NCBI)ITPKB
Gene ExpressionITPKB [ NCBI-GEO ]   ITPKB [ EBI - ARRAY_EXPRESS ]   ITPKB [ SEEK ]   ITPKB [ MEM ]
Gene Expression Viewer (FireBrowse)ITPKB [ Firebrowse - Broad ]
GenevisibleExpression of ITPKB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3707
GTEX Portal (Tissue expression)ITPKB
Human Protein AtlasENSG00000143772-ITPKB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27987   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27987  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27987
Catalytic activity : Enzyme2.7.1.127 [ Enzyme-Expasy ]   2.7.1.1272.7.1.127 [ IntEnz-EBI ]   2.7.1.127 [ BRENDA ]   2.7.1.127 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP27987
Domains : Interpro (EBI)IPK    IPK_sf   
Domain families : Pfam (Sanger)IPK (PF03770)   
Domain families : Pfam (NCBI)pfam03770   
Conserved Domain (NCBI)ITPKB
SuperfamilyP27987
AlphaFold pdb e-kbP27987   
Human Protein Atlas [tissue]ENSG00000143772-ITPKB [tissue]
HPRD00942
Protein Interaction databases
DIP (DOE-UCLA)P27987
IntAct (EBI)P27987
BioGRIDITPKB
STRING (EMBL)ITPKB
ZODIACITPKB
Ontologies - Pathways
QuickGOP27987
Ontology : AmiGOMAPK cascade  inositol hexakisphosphate kinase activity  regulation of protein phosphorylation  myeloid cell homeostasis  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  signal transduction  cell surface receptor signaling pathway  inositol-1,4,5-trisphosphate 3-kinase activity  membrane  kinase activity  phosphorylation  inositol trisphosphate metabolic process  inositol phosphate biosynthetic process  negative regulation of neutrophil apoptotic process  common myeloid progenitor cell proliferation  inositol phosphate metabolic process  positive thymic T cell selection  negative regulation of myeloid cell differentiation  positive regulation of Ras protein signal transduction  positive regulation of alpha-beta T cell differentiation  phosphatidylinositol phosphate biosynthetic process  cellular response to calcium ion  
Ontology : EGO-EBIMAPK cascade  inositol hexakisphosphate kinase activity  regulation of protein phosphorylation  myeloid cell homeostasis  protein binding  calmodulin binding  ATP binding  nucleus  cytoplasm  cytosol  signal transduction  cell surface receptor signaling pathway  inositol-1,4,5-trisphosphate 3-kinase activity  membrane  kinase activity  phosphorylation  inositol trisphosphate metabolic process  inositol phosphate biosynthetic process  negative regulation of neutrophil apoptotic process  common myeloid progenitor cell proliferation  inositol phosphate metabolic process  positive thymic T cell selection  negative regulation of myeloid cell differentiation  positive regulation of Ras protein signal transduction  positive regulation of alpha-beta T cell differentiation  phosphatidylinositol phosphate biosynthetic process  cellular response to calcium ion  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system   
NDEx NetworkITPKB
Atlas of Cancer Signalling NetworkITPKB
Wikipedia pathwaysITPKB
Orthology - Evolution
OrthoDB3707
GeneTree (enSembl)ENSG00000143772
Phylogenetic Trees/Animal Genes : TreeFamITPKB
Homologs : HomoloGeneITPKB
Homology/Alignments : Family Browser (UCSC)ITPKB
Gene fusions - Rearrangements
Fusion : MitelmanITPKB/ZC3HAV1 [1q42.12/7q34]  
Fusion : MitelmanZC3HAV1/ITPKB [7q34/1q42.12]  
Fusion : QuiverITPKB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITPKB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITPKB
dbVarITPKB
ClinVarITPKB
MonarchITPKB
1000_GenomesITPKB 
Exome Variant ServerITPKB
GNOMAD BrowserENSG00000143772
Varsome BrowserITPKB
ACMGITPKB variants
VarityP27987
Genomic Variants (DGV)ITPKB [DGVbeta]
DECIPHERITPKB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITPKB 
Mutations
ICGC Data PortalITPKB 
TCGA Data PortalITPKB 
Broad Tumor PortalITPKB
OASIS PortalITPKB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITPKB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DITPKB
Mutations and Diseases : HGMDITPKB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaITPKB
DgiDB (Drug Gene Interaction Database)ITPKB
DoCM (Curated mutations)ITPKB
CIViC (Clinical Interpretations of Variants in Cancer)ITPKB
Cancer3DITPKB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147522   
Orphanet
DisGeNETITPKB
MedgenITPKB
Genetic Testing Registry ITPKB
NextProtP27987 [Medical]
GENETestsITPKB
Target ValidationITPKB
Huge Navigator ITPKB [HugePedia]
ClinGenITPKB
Clinical trials, drugs, therapy
MyCancerGenomeITPKB
Protein Interactions : CTDITPKB
Pharm GKB GenePA29976
PharosP27987
Clinical trialITPKB
Miscellaneous
canSAR (ICR)ITPKB
HarmonizomeITPKB
DataMed IndexITPKB
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXITPKB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:24 CEST 2021

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