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ITPKC (inositol-trisphosphate 3-kinase C)

Identity

Other namesIP3-3KC
IP3KC
HGNC (Hugo) ITPKC
LocusID (NCBI) 80271
Location 19q13.2
Location_base_pair Starts at 41223008 and ends at 41246765 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ITPKC   14897
Cards
Entrez_Gene (NCBI)ITPKC  80271  inositol-trisphosphate 3-kinase C
GeneCards (Weizmann)ITPKC
Ensembl hg19 (Hinxton)ENSG00000086544 [Gene_View]  chr19:41223008-41246765 [Contig_View]  ITPKC [Vega]
Ensembl hg38 (Hinxton)ENSG00000086544 [Gene_View]  chr19:41223008-41246765 [Contig_View]  ITPKC [Vega]
ICGC DataPortalENSG00000086544
cBioPortalITPKC
AceView (NCBI)ITPKC
Genatlas (Paris)ITPKC
WikiGenes80271
SOURCE (Princeton)ITPKC
Genomic and cartography
GoldenPath hg19 (UCSC)ITPKC  -     chr19:41223008-41246765 +  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ITPKC  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblITPKC - 19q13.2 [CytoView hg19]  ITPKC - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIITPKC [Mapview hg19]  ITPKC [Mapview hg38]
OMIM606476   611775   
Gene and transcription
Genbank (Entrez)AJ290975 AK024596 BC026903 BC060788 D38169
RefSeq transcript (Entrez)NM_025194
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_012970 NT_011109 NW_001838496 NW_004929415
Consensus coding sequences : CCDS (NCBI)ITPKC
Cluster EST : UnigeneHs.515415 [ NCBI ]
CGAP (NCI)Hs.515415
Alternative Splicing : Fast-db (Paris)GSHG0014933
Alternative Splicing GalleryENSG00000086544
Gene ExpressionITPKC [ NCBI-GEO ]     ITPKC [ SEEK ]   ITPKC [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DU7 (Uniprot)
NextProtQ96DU7  [Medical]
With graphics : InterProQ96DU7
Splice isoforms : SwissVarQ96DU7 (Swissvar)
Catalytic activity : Enzyme2.7.1.127 [ Enzyme-Expasy ]   2.7.1.1272.7.1.127 [ IntEnz-EBI ]   2.7.1.127 [ BRENDA ]   2.7.1.127 [ KEGG ]   
Domains : Interpro (EBI)IPK   
Related proteins : CluSTrQ96DU7
Domain families : Pfam (Sanger)IPK (PF03770)   
Domain families : Pfam (NCBI)pfam03770   
DMDM Disease mutations80271
Blocks (Seattle)Q96DU7
PDB (SRS)2A98   
PDB (PDBSum)2A98   
PDB (IMB)2A98   
PDB (RSDB)2A98   
Human Protein AtlasENSG00000086544
Peptide AtlasQ96DU7
HPRD09400
IPIIPI00061203   
Protein Interaction databases
DIP (DOE-UCLA)Q96DU7
IntAct (EBI)Q96DU7
FunCoupENSG00000086544
BioGRIDITPKC
IntegromeDBITPKC
STRING (EMBL)ITPKC
Ontologies - Pathways
QuickGOQ96DU7
Ontology : AmiGOcalmodulin binding  ATP binding  nucleus  cytosol  inositol-1,4,5-trisphosphate 3-kinase activity  phosphorylation  inositol phosphate metabolic process  small molecule metabolic process  
Ontology : EGO-EBIcalmodulin binding  ATP binding  nucleus  cytosol  inositol-1,4,5-trisphosphate 3-kinase activity  phosphorylation  inositol phosphate metabolic process  small molecule metabolic process  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system   
Protein Interaction DatabaseITPKC
DoCM (Curated mutations)ITPKC
Wikipedia pathwaysITPKC
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerITPKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITPKC
dbVarITPKC
ClinVarITPKC
1000_GenomesITPKC 
Exome Variant ServerITPKC
SNP (GeneSNP Utah)ITPKC
SNP : HGBaseITPKC
Genetic variants : HAPMAPITPKC
Genomic VariantsITPKC  ITPKC [DGVbeta]
Mutations
ICGC Data PortalENSG00000086544 
Somatic Mutations in Cancer : COSMICITPKC 
CONAN: Copy Number AnalysisITPKC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:41223008-41246765
Mutations and Diseases : HGMDITPKC
OMIM606476    611775   
MedgenITPKC
NextProtQ96DU7 [Medical]
GENETestsITPKC
Disease Genetic AssociationITPKC
Huge Navigator ITPKC [HugePedia]  ITPKC [HugeCancerGEM]
snp3D : Map Gene to Disease80271
DGIdb (Drug Gene Interaction db)ITPKC
General knowledge
Homologs : HomoloGeneITPKC
Homology/Alignments : Family Browser (UCSC)ITPKC
Phylogenetic Trees/Animal Genes : TreeFamITPKC
Chemical/Protein Interactions : CTD80271
Chemical/Pharm GKB GenePA29977
Clinical trialITPKC
Cancer Resource (Charite)ENSG00000086544
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
CoreMineITPKC
GoPubMedITPKC
iHOPITPKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:13:14 CET 2014

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