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IVD (isovaleryl-CoA dehydrogenase)

Identity

Alias_namesisovaleryl Coenzyme A dehydrogenase
isovaleryl CoA dehydrogenase
Alias_symbol (synonym)ACAD2
Other alias
HGNC (Hugo) IVD
LocusID (NCBI) 3712
Atlas_Id 64701
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40405485 and ends at 40421313 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IVD (15q15.1) / IVD (15q15.1)IVD (15q15.1) / KNSTRN (15q15.1)IVD (15q15.1) / MALAT1 (11q13.1)
IVD (15q15.1) / PTGES (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IVD   6186
Cards
Entrez_Gene (NCBI)IVD  3712  isovaleryl-CoA dehydrogenase
AliasesACAD2
GeneCards (Weizmann)IVD
Ensembl hg19 (Hinxton)ENSG00000128928 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128928 [Gene_View]  chr15:40405485-40421313 [Contig_View]  IVD [Vega]
ICGC DataPortalENSG00000128928
TCGA cBioPortalIVD
AceView (NCBI)IVD
Genatlas (Paris)IVD
WikiGenes3712
SOURCE (Princeton)IVD
Genetics Home Reference (NIH)IVD
Genomic and cartography
GoldenPath hg38 (UCSC)IVD  -     chr15:40405485-40421313 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IVD  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblIVD - 15q15.1 [CytoView hg19]  IVD - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIIVD [Mapview hg19]  IVD [Mapview hg38]
OMIM243500   607036   
Gene and transcription
Genbank (Entrez)AF070531 AI086669 AK022777 AK092168 AK122922
RefSeq transcript (Entrez)NM_001159508 NM_002225
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IVD
Cluster EST : UnigeneHs.513646 [ NCBI ]
CGAP (NCI)Hs.513646
Alternative Splicing GalleryENSG00000128928
Gene ExpressionIVD [ NCBI-GEO ]   IVD [ EBI - ARRAY_EXPRESS ]   IVD [ SEEK ]   IVD [ MEM ]
Gene Expression Viewer (FireBrowse)IVD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3712
GTEX Portal (Tissue expression)IVD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26440   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26440  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26440
Splice isoforms : SwissVarP26440
Catalytic activity : Enzyme1.3.8.4 [ Enzyme-Expasy ]   1.3.8.41.3.8.4 [ IntEnz-EBI ]   1.3.8.4 [ BRENDA ]   1.3.8.4 [ KEGG ]   
PhosPhoSitePlusP26440
Domaine pattern : Prosite (Expaxy)ACYL_COA_DH_1 (PS00072)    ACYL_COA_DH_2 (PS00073)   
Domains : Interpro (EBI)Acyl-CoA_DH_CS    Acyl-CoA_Oxase/DH_cen-dom    AcylCo_DH/oxidase_C    AcylCoA_DH/ox_N    AcylCoA_DH/oxidase_NM_dom    IVD   
Domain families : Pfam (Sanger)Acyl-CoA_dh_1 (PF00441)    Acyl-CoA_dh_M (PF02770)    Acyl-CoA_dh_N (PF02771)   
Domain families : Pfam (NCBI)pfam00441    pfam02770    pfam02771   
Conserved Domain (NCBI)IVD
DMDM Disease mutations3712
Blocks (Seattle)IVD
PDB (SRS)1IVH   
PDB (PDBSum)1IVH   
PDB (IMB)1IVH   
PDB (RSDB)1IVH   
Structural Biology KnowledgeBase1IVH   
SCOP (Structural Classification of Proteins)1IVH   
CATH (Classification of proteins structures)1IVH   
SuperfamilyP26440
Human Protein AtlasENSG00000128928
Peptide AtlasP26440
HPRD09516
IPIIPI00645805   IPI00890775   IPI00789848   IPI00929108   IPI00946851   IPI01014702   
Protein Interaction databases
DIP (DOE-UCLA)P26440
IntAct (EBI)P26440
FunCoupENSG00000128928
BioGRIDIVD
STRING (EMBL)IVD
ZODIACIVD
Ontologies - Pathways
QuickGOP26440
Ontology : AmiGOmitochondrial matrix  mitochondrial matrix  leucine catabolic process  leucine catabolic process  isovaleryl-CoA dehydrogenase activity  isovaleryl-CoA dehydrogenase activity  branched-chain amino acid catabolic process  flavin adenine dinucleotide binding  oxidation-reduction process  
Ontology : EGO-EBImitochondrial matrix  mitochondrial matrix  leucine catabolic process  leucine catabolic process  isovaleryl-CoA dehydrogenase activity  isovaleryl-CoA dehydrogenase activity  branched-chain amino acid catabolic process  flavin adenine dinucleotide binding  oxidation-reduction process  
Pathways : KEGGValine, leucine and isoleucine degradation   
NDEx NetworkIVD
Atlas of Cancer Signalling NetworkIVD
Wikipedia pathwaysIVD
Orthology - Evolution
OrthoDB3712
GeneTree (enSembl)ENSG00000128928
Phylogenetic Trees/Animal Genes : TreeFamIVD
HOVERGENP26440
HOGENOMP26440
Homologs : HomoloGeneIVD
Homology/Alignments : Family Browser (UCSC)IVD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIVD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IVD
dbVarIVD
ClinVarIVD
1000_GenomesIVD 
Exome Variant ServerIVD
ExAC (Exome Aggregation Consortium)IVD (select the gene name)
Genetic variants : HAPMAP3712
Genomic Variants (DGV)IVD [DGVbeta]
DECIPHERIVD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIVD 
Mutations
ICGC Data PortalIVD 
TCGA Data PortalIVD 
Broad Tumor PortalIVD
OASIS PortalIVD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIVD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIVD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IVD
DgiDB (Drug Gene Interaction Database)IVD
DoCM (Curated mutations)IVD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IVD (select a term)
intoGenIVD
Cancer3DIVD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM243500    607036   
Orphanet399   
MedgenIVD
Genetic Testing Registry IVD
NextProtP26440 [Medical]
TSGene3712
GENETestsIVD
Target ValidationIVD
Huge Navigator IVD [HugePedia]
snp3D : Map Gene to Disease3712
BioCentury BCIQIVD
ClinGenIVD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3712
Chemical/Pharm GKB GenePA29984
Clinical trialIVD
Miscellaneous
canSAR (ICR)IVD (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIVD
EVEXIVD
GoPubMedIVD
iHOPIVD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:53:48 CEST 2017

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