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IZUMO1 (izumo sperm-egg fusion 1)

Identity

Alias (NCBI)IZUMO
OBF
HGNC (Hugo) IZUMO1
HGNC Alias symbIZUMO
MGC34799
OBF
HGNC Alias nameoocyte binding/fusion factor
LocusID (NCBI) 284359
Atlas_Id 56314
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48740852 and ends at 48746909 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IZUMO1 (19q13.33) / MYADM (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)IZUMO1   28539
Cards
Entrez_Gene (NCBI)IZUMO1    izumo sperm-egg fusion 1
AliasesIZUMO; OBF
GeneCards (Weizmann)IZUMO1
Ensembl hg19 (Hinxton)ENSG00000182264 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182264 [Gene_View]  ENSG00000182264 [Sequence]  chr19:48740852-48746909 [Contig_View]  IZUMO1 [Vega]
ICGC DataPortalENSG00000182264
TCGA cBioPortalIZUMO1
AceView (NCBI)IZUMO1
Genatlas (Paris)IZUMO1
SOURCE (Princeton)IZUMO1
Genetics Home Reference (NIH)IZUMO1
Genomic and cartography
GoldenPath hg38 (UCSC)IZUMO1  -     chr19:48740852-48746909 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IZUMO1  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathIZUMO1 - 19q13.33 [CytoView hg19]  IZUMO1 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000182264
genome Data Viewer NCBIIZUMO1 [Mapview hg19]  
OMIM609278   
Gene and transcription
Genbank (Entrez)AB195682 AK301750 AY552609 AY552610 BC034769
RefSeq transcript (Entrez)NM_001321864 NM_001321865 NM_182575
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IZUMO1
Alternative Splicing GalleryENSG00000182264
Gene ExpressionIZUMO1 [ NCBI-GEO ]   IZUMO1 [ EBI - ARRAY_EXPRESS ]   IZUMO1 [ SEEK ]   IZUMO1 [ MEM ]
Gene Expression Viewer (FireBrowse)IZUMO1 [ Firebrowse - Broad ]
GenevisibleExpression of IZUMO1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284359
GTEX Portal (Tissue expression)IZUMO1
Human Protein AtlasENSG00000182264-IZUMO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYV9
Splice isoforms : SwissVarQ8IYV9
PhosPhoSitePlusQ8IYV9
Domains : Interpro (EBI)Ig-like_dom_sf    Ig-like_fold    IZUMO    Izumo-Ig    IZUMO1   
Domain families : Pfam (Sanger)IZUMO (PF15005)    Izumo-Ig (PF16706)   
Domain families : Pfam (NCBI)pfam15005    pfam16706   
Conserved Domain (NCBI)IZUMO1
Blocks (Seattle)IZUMO1
PDB (RSDB)5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
PDB Europe5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
PDB (PDBSum)5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
PDB (IMB)5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
Structural Biology KnowledgeBase5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
SCOP (Structural Classification of Proteins)5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
CATH (Classification of proteins structures)5F4E    5F4T    5F4V    5JK9    5JKC    5JKD    5JKE   
SuperfamilyQ8IYV9
Human Protein Atlas [tissue]ENSG00000182264-IZUMO1 [tissue]
Peptide AtlasQ8IYV9
HPRD14589
IPIIPI00217891   IPI00719793   IPI00719606   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYV9
IntAct (EBI)Q8IYV9
BioGRIDIZUMO1
STRING (EMBL)IZUMO1
ZODIACIZUMO1
Ontologies - Pathways
QuickGOQ8IYV9
Ontology : AmiGOacrosomal membrane  acrosomal membrane  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  cell adhesion  single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  integral component of membrane  integral component of membrane  heterotypic cell-cell adhesion  heterotypic cell-cell adhesion  sperm-egg recognition  sperm-egg recognition  protein homodimerization activity  protein binding involved in heterotypic cell-cell adhesion  protein binding involved in heterotypic cell-cell adhesion  
Ontology : EGO-EBIacrosomal membrane  acrosomal membrane  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  cell adhesion  single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  fusion of sperm to egg plasma membrane involved in single fertilization  integral component of membrane  integral component of membrane  heterotypic cell-cell adhesion  heterotypic cell-cell adhesion  sperm-egg recognition  sperm-egg recognition  protein homodimerization activity  protein binding involved in heterotypic cell-cell adhesion  protein binding involved in heterotypic cell-cell adhesion  
NDEx NetworkIZUMO1
Atlas of Cancer Signalling NetworkIZUMO1
Wikipedia pathwaysIZUMO1
Orthology - Evolution
OrthoDB284359
GeneTree (enSembl)ENSG00000182264
Phylogenetic Trees/Animal Genes : TreeFamIZUMO1
HOGENOMQ8IYV9
Homologs : HomoloGeneIZUMO1
Homology/Alignments : Family Browser (UCSC)IZUMO1
Gene fusions - Rearrangements
Fusion : QuiverIZUMO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIZUMO1 [hg38]
dbVarIZUMO1
ClinVarIZUMO1
MonarchIZUMO1
1000_GenomesIZUMO1 
Exome Variant ServerIZUMO1
GNOMAD BrowserENSG00000182264
Varsome BrowserIZUMO1
Genomic Variants (DGV)IZUMO1 [DGVbeta]
DECIPHERIZUMO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIZUMO1 
Mutations
ICGC Data PortalIZUMO1 
TCGA Data PortalIZUMO1 
Broad Tumor PortalIZUMO1
OASIS PortalIZUMO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIZUMO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIZUMO1
Mutations and Diseases : HGMDIZUMO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IZUMO1
DgiDB (Drug Gene Interaction Database)IZUMO1
DoCM (Curated mutations)IZUMO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IZUMO1 (select a term)
intoGenIZUMO1
Cancer3DIZUMO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609278   
Orphanet
DisGeNETIZUMO1
MedgenIZUMO1
Genetic Testing Registry IZUMO1
NextProtQ8IYV9 [Medical]
GENETestsIZUMO1
Target ValidationIZUMO1
Huge Navigator IZUMO1 [HugePedia]
ClinGenIZUMO1
Clinical trials, drugs, therapy
MyCancerGenomeIZUMO1
Protein Interactions : CTD
Pharm GKB GenePA142671647
PharosQ8IYV9
Clinical trialIZUMO1
Miscellaneous
canSAR (ICR)IZUMO1 (select the gene name)
HarmonizomeIZUMO1
DataMed IndexIZUMO1
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIZUMO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:27:16 CET 2021

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