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IZUMO1 (izumo sperm-egg fusion 1)

Identity

Alias_symbol (synonym)IZUMO
MGC34799
OBF
Other alias
HGNC (Hugo) IZUMO1
LocusID (NCBI) 284359
Atlas_Id 56314
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49244145 and ends at 49250166 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IZUMO1 (19q13.33) / MYADM (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IZUMO1   28539
Cards
Entrez_Gene (NCBI)IZUMO1  284359  izumo sperm-egg fusion 1
AliasesIZUMO; OBF
GeneCards (Weizmann)IZUMO1
Ensembl hg19 (Hinxton)ENSG00000182264 [Gene_View]  chr19:49244145-49250166 [Contig_View]  IZUMO1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182264 [Gene_View]  chr19:49244145-49250166 [Contig_View]  IZUMO1 [Vega]
ICGC DataPortalENSG00000182264
TCGA cBioPortalIZUMO1
AceView (NCBI)IZUMO1
Genatlas (Paris)IZUMO1
WikiGenes284359
SOURCE (Princeton)IZUMO1
Genetics Home Reference (NIH)IZUMO1
Genomic and cartography
GoldenPath hg19 (UCSC)IZUMO1  -     chr19:49244145-49250166 -  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IZUMO1  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblIZUMO1 - 19q13.33 [CytoView hg19]  IZUMO1 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIIZUMO1 [Mapview hg19]  IZUMO1 [Mapview hg38]
OMIM609278   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001321864 NM_001321865 NM_182575
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IZUMO1
Cluster EST : UnigeneHs.400688 [ NCBI ]
CGAP (NCI)Hs.400688
Alternative Splicing GalleryENSG00000182264
Gene ExpressionIZUMO1 [ NCBI-GEO ]   IZUMO1 [ EBI - ARRAY_EXPRESS ]   IZUMO1 [ SEEK ]   IZUMO1 [ MEM ]
Gene Expression Viewer (FireBrowse)IZUMO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284359
GTEX Portal (Tissue expression)IZUMO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYV9
Splice isoforms : SwissVarQ8IYV9
PhosPhoSitePlusQ8IYV9
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    IZUMO    Izumo-Ig    IZUMO1   
Domain families : Pfam (Sanger)IZUMO (PF15005)    Izumo-Ig (PF16706)   
Domain families : Pfam (NCBI)pfam15005    pfam16706   
Conserved Domain (NCBI)IZUMO1
DMDM Disease mutations284359
Blocks (Seattle)IZUMO1
SuperfamilyQ8IYV9
Human Protein AtlasENSG00000182264
Peptide AtlasQ8IYV9
HPRD14589
IPIIPI00217891   IPI00719793   IPI00719606   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYV9
IntAct (EBI)Q8IYV9
FunCoupENSG00000182264
BioGRIDIZUMO1
STRING (EMBL)IZUMO1
ZODIACIZUMO1
Ontologies - Pathways
QuickGOQ8IYV9
Ontology : AmiGOacrosomal membrane  receptor binding  protein binding  plasma membrane  plasma membrane  cell adhesion  single fertilization  fusion of sperm to egg plasma membrane  fusion of sperm to egg plasma membrane  integral component of membrane  heterotypic cell-cell adhesion  sperm-egg recognition  protein homodimerization activity  protein binding involved in heterotypic cell-cell adhesion  
Ontology : EGO-EBIacrosomal membrane  receptor binding  protein binding  plasma membrane  plasma membrane  cell adhesion  single fertilization  fusion of sperm to egg plasma membrane  fusion of sperm to egg plasma membrane  integral component of membrane  heterotypic cell-cell adhesion  sperm-egg recognition  protein homodimerization activity  protein binding involved in heterotypic cell-cell adhesion  
NDEx NetworkIZUMO1
Atlas of Cancer Signalling NetworkIZUMO1
Wikipedia pathwaysIZUMO1
Orthology - Evolution
OrthoDB284359
GeneTree (enSembl)ENSG00000182264
Phylogenetic Trees/Animal Genes : TreeFamIZUMO1
HOVERGENQ8IYV9
HOGENOMQ8IYV9
Homologs : HomoloGeneIZUMO1
Homology/Alignments : Family Browser (UCSC)IZUMO1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIZUMO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IZUMO1
dbVarIZUMO1
ClinVarIZUMO1
1000_GenomesIZUMO1 
Exome Variant ServerIZUMO1
ExAC (Exome Aggregation Consortium)IZUMO1 (select the gene name)
Genetic variants : HAPMAP284359
Genomic Variants (DGV)IZUMO1 [DGVbeta]
DECIPHER (Syndromes)19:49244145-49250166  ENSG00000182264
CONAN: Copy Number AnalysisIZUMO1 
Mutations
ICGC Data PortalIZUMO1 
TCGA Data PortalIZUMO1 
Broad Tumor PortalIZUMO1
OASIS PortalIZUMO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIZUMO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIZUMO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IZUMO1
DgiDB (Drug Gene Interaction Database)IZUMO1
DoCM (Curated mutations)IZUMO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IZUMO1 (select a term)
intoGenIZUMO1
Cancer3DIZUMO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609278   
Orphanet
MedgenIZUMO1
Genetic Testing Registry IZUMO1
NextProtQ8IYV9 [Medical]
TSGene284359
GENETestsIZUMO1
Huge Navigator IZUMO1 [HugePedia]
snp3D : Map Gene to Disease284359
BioCentury BCIQIZUMO1
ClinGenIZUMO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284359
Chemical/Pharm GKB GenePA142671647
Clinical trialIZUMO1
Miscellaneous
canSAR (ICR)IZUMO1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIZUMO1
EVEXIZUMO1
GoPubMedIZUMO1
iHOPIZUMO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:41 CEST 2017

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