JAK1 (Janus kinase 1 (a protein tyrosine kinase))

Identity

Other names	JAK1A
	JAK1B
	JTK3
HGNC	JAK1
Location	1p32.3-p31.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	JAK1   6190
Entrez_Gene	JAK1  3716  Janus kinase 1 (a protein tyrosine kinase)
	Cards
GeneCards	JAK1
Ensembl	JAK1 [Search_View]   ENSG00000162434 [Gene_View]
Genatlas	JAK1
GeneLynx	JAK1
eGenome	JAK1
euGene	3716
	Genomic and cartography
GoldenPath	JAK1  -     chr1:65071494-65204775 -  1p31.3   [Description]    (hg18-March_2006)
Ensembl	JAK1 - 1p31.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	JAK1
	Gene and transcription
Genbank	AB209057 [ ENTREZ ]
Genbank	AB219242 [ ENTREZ ]
Genbank	AK128375 [ ENTREZ ]
Genbank	AK314257 [ ENTREZ ]
Genbank	BC009079 [ ENTREZ ]
RefSeq	NM_002227 [ SRS ]    NM_002227 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_032977 [ SRS ]    NT_032977 [ ENTREZ ]
RefSeq	NW_001838579 [ SRS ]    NW_001838579 [ ENTREZ ]
RefSeq	NW_921351 [ SRS ]    NW_921351 [ ENTREZ ]
AceView	JAK1 AceView - NCBI
Unigene	Hs.207538 [ SRS ]    Hs.207538 [ NCBI ]     HS207538 [ spliceNest ]
Fast-db	16404 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P23458 [ SRS]    P23458 [ EXPASY ]     P23458 [ INTERPRO ]     P23458 [ UNIPROT ]
Prosite	PS00660 FERM_1 [ SRS ]    PS00660 FERM_1 [ Expasy ]
Prosite	PS00661 FERM_2 [ SRS ]    PS00661 FERM_2 [ Expasy ]
Prosite	PS50057 FERM_3 [ SRS ]    PS50057 FERM_3 [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Interpro	IPR000299 Band_4.1_N [ SRS ]    IPR000299 Band_4.1_N [ EBI ]
Interpro	IPR009127 JAK [ SRS ]    IPR009127 JAK [ EBI ]
Interpro	IPR009128 JAK1 [ SRS ]    IPR009128 JAK1 [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
Interpro	IPR016251 TyrPK_Jak [ SRS ]    IPR016251 TyrPK_Jak [ EBI ]
CluSTr	P23458
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00295 B41 [EMBL]
Smart	SM00252 SH2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P23458 JAK1_HUMAN [ Domain structure ]   P23458 JAK1_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000001[INRA-Toulouse]
Prodom	P23458 JAK1_HUMAN [ Domain structure ]   P23458 JAK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P23458
HPRD	00992
	Protein Interaction databases
DIP	P23458
IntAct	P23458
	Polymorphism : SNP, mutations, diseases
OMIM	147795    [ map ]
GENECLINICS	147795
SNP	JAK1 [dbSNP-NCBI]
SNP	NM_002227 [SNP-NCI]
SNP	JAK1 [GeneSNPs - Utah]  JAK1] [HGBASE - SRS]
HAPMAP	JAK1 [HAPMAP]
COSMIC	JAK1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	JAK1
	General knowledge
Family Browser	JAK1 [UCSC Family Browser]
SOURCE	NM_002227
SMD	Hs.207538
SAGE	Hs.207538
Enzyme	2.7.10.2 [ Enzyme-Expasy ]   2.7.10.2 [ Enzyme-SRS ]   2.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   2.7.10.2 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	non-membrane spanning protein tyrosine kinase activity [Amigo]  non-membrane spanning protein tyrosine kinase activity
GO	Janus kinase activity [Amigo]  Janus kinase activity
GO	growth hormone receptor binding [Amigo]  growth hormone receptor binding
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoskeleton [Amigo]  cytoskeleton
GO	enzyme linked receptor protein signaling pathway [Amigo]  enzyme linked receptor protein signaling pathway
GO	protein kinase cascade [Amigo]  protein kinase cascade
GO	endomembrane system [Amigo]  endomembrane system
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
GO	peptidyl-tyrosine phosphorylation [Amigo]  peptidyl-tyrosine phosphorylation
GO	cytokine and chemokine mediated signaling pathway [Amigo]  cytokine and chemokine mediated signaling pathway
BIOCARTA	EGF Signaling Pathway    [Genes]
BIOCARTA	IFN alpha signaling pathway    [Genes]
BIOCARTA	IFN gamma signaling pathway    [Genes]
BIOCARTA	IL-10 Anti-inflammatory Signaling Pathway    [Genes]
BIOCARTA	IL 2 signaling pathway    [Genes]
BIOCARTA	IL-2 Receptor Beta Chain in T cell Activation    [Genes]
BIOCARTA	IL 4 signaling pathway    [Genes]
BIOCARTA	IL-7 Signal Transduction    [Genes]
BIOCARTA	PDGF Signaling Pathway    [Genes]
KEGG	Jak-STAT signaling pathway
KEGG	Adipocytokine signaling pathway
PubGene	JAK1
TreeFam	JAK1
CTD	3716 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	JAK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	96 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:16:46 2008