JAM2 (junctional adhesion molecule 2)

2013-08-01  

Identity

HGNC
JAM2
LOCATION
21q21.3
LOCUSID
58494
ALIAS
C21orf43,CD322,IBGC8,JAM-B,JAMB,PRO245,VE-JAM,VEJAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58494
MIM: 606870
HGNC: 14686
Ensembl: ENSG00000154721

Variants:

dbSNP: 58494
ClinVar: 58494
TCGA: ENSG00000154721
COSMIC: JAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154721ENST00000312957P57087
ENSG00000154721ENST00000400532P57087
ENSG00000154721ENST00000460679H0YEX9
ENSG00000154721ENST00000480456P57087

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

References

Pubmed IDYearTitleCitations
120701352002JAM2 interacts with alpha4beta1. Facilitation by JAM3.38
120701352002JAM2 interacts with alpha4beta1. Facilitation by JAM3.38
109459762000A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions.32
118234892002Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3.32
232772822013Junctional adhesion molecules 2 and 3 may potentially be involved in progression of gastric adenocarcinoma tumors.11
124760452002Junctional adhesion molecules and interendothelial junctions.10
295750132018MicroRNA-374b inhibits cervical cancer cell proliferation and induces apoptosis through the p38/ERK signaling pathway by binding to JAM-2.8
243570682014Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.7
178227252008Expression of junctional adhesion molecules on the human lymphatic endothelium.5
256496522015Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts.5

Citation

Dessen P

JAM2 (junctional adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53483/jam2