JARID2 (jumonji and AT-rich interaction domain containing 2)

2003-05-01  

Identity

HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
JMJ
FUSION GENES

Other Information

Locus ID:

NCBI: 3720
MIM: 601594
HGNC: 6196
Ensembl: ENSG00000008083

Variants:

dbSNP: 3720
ClinVar: 3720
TCGA: ENSG00000008083
COSMIC: JARID2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008083ENST00000341776Q92833
ENSG00000008083ENST00000397311Q92833

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200758572010JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.227
243743122014Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.150
244622042014Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.88
256205642015Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.64
248569002014miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression.56
197591542009Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival.48
221900182012Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.35
234354162014JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.35
248896932014miRNA-940 reduction contributes to human Tetralogy of Fallot development.19
169674652007Positive association of schizophrenia to JARID2 gene.18

Citation

Dessen P

JARID2 (jumonji and AT-rich interaction domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41035/jarid2