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JARID2 (jumonji and AT-rich interaction domain containing 2)

Identity

Alias (NCBI)JMJ
HGNC (Hugo) JARID2
HGNC Previous nameJMJ
HGNC Previous namejumonji (mouse) homolog
 Jumonji, AT rich interactive domain 2
 jumonji, AT rich interactive domain 2
LocusID (NCBI) 3720
Atlas_Id 41035
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 15246069 and ends at 15522042 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JARID2 (6p22.3) / ATM (11q22.3)JARID2 (6p22.3) / HSD3B1 (1p12)JARID2 (6p22.3) / PPP1R10 (6p21.33)
JARID2 (6p22.3) / RPL23 (17q12)JARID2 (6p22.3) / ZNF423 (16q12.1)KCTD20 (6p21.31) / JARID2 (6p22.3)
RPL23 (17q12) / JARID2 (6p22.3)STX12 (1p35.3) / JARID2 (6p22.3)JARID2 6p22.3 / ATM 11q22.3
JARID2 6p22.3 / HSD3B1 1p12JARID2 6p22.3 / PPP1R10 6p21.33KCTD20 6p21.31 / JARID2 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(6p) (loss of JARID2 and DTNBP1) in myeloid malignances


External links

 

Nomenclature
HGNC (Hugo)JARID2   6196
Cards
Entrez_Gene (NCBI)JARID2    jumonji and AT-rich interaction domain containing 2
AliasesJMJ
GeneCards (Weizmann)JARID2
Ensembl hg19 (Hinxton)ENSG00000008083 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008083 [Gene_View]  ENSG00000008083 [Sequence]  chr6:15246069-15522042 [Contig_View]  JARID2 [Vega]
ICGC DataPortalENSG00000008083
TCGA cBioPortalJARID2
AceView (NCBI)JARID2
Genatlas (Paris)JARID2
SOURCE (Princeton)JARID2
Genetics Home Reference (NIH)JARID2
Genomic and cartography
GoldenPath hg38 (UCSC)JARID2  -     chr6:15246069-15522042 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JARID2  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathJARID2 - 6p22.3 [CytoView hg19]  JARID2 - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000008083
Genome Data Viewer NCBIJARID2 [Mapview hg19]  
OMIM601594   
Gene and transcription
Genbank (Entrez)AF401209 AK126552 AK292861 AK299349 AK302624
RefSeq transcript (Entrez)NM_001267040 NM_004973
Consensus coding sequences : CCDS (NCBI)JARID2
Gene ExpressionJARID2 [ NCBI-GEO ]   JARID2 [ EBI - ARRAY_EXPRESS ]   JARID2 [ SEEK ]   JARID2 [ MEM ]
Gene Expression Viewer (FireBrowse)JARID2 [ Firebrowse - Broad ]
GenevisibleExpression of JARID2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3720
GTEX Portal (Tissue expression)JARID2
Human Protein AtlasENSG00000008083-JARID2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92833   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92833  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92833
PhosPhoSitePlusQ92833
Domaine pattern : Prosite (Expaxy)ARID (PS51011)    JMJC (PS51184)    JMJN (PS51183)   
Domains : Interpro (EBI)ARID_dom    ARID_dom_sf    JmjC_dom    JmjN    Znf_C5HC2   
Domain families : Pfam (Sanger)ARID (PF01388)    JmjC (PF02373)    JmjN (PF02375)    zf-C5HC2 (PF02928)   
Domain families : Pfam (NCBI)pfam01388    pfam02373    pfam02375    pfam02928   
Domain families : Smart (EMBL)BRIGHT (SM00501)  JmjC (SM00558)  JmjN (SM00545)  
Conserved Domain (NCBI)JARID2
PDB (RSDB)5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
PDB Europe5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
PDB (PDBSum)5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
PDB (IMB)5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
Structural Biology KnowledgeBase5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
SCOP (Structural Classification of Proteins)5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
CATH (Classification of proteins structures)5HYN    5LS6    5WAI    6C23    6C24    6NQ3   
SuperfamilyQ92833
AlphaFold pdb e-kbQ92833   
Human Protein Atlas [tissue]ENSG00000008083-JARID2 [tissue]
HPRD03355
Protein Interaction databases
DIP (DOE-UCLA)Q92833
IntAct (EBI)Q92833
BioGRIDJARID2
STRING (EMBL)JARID2
ZODIACJARID2
Ontologies - Pathways
QuickGOQ92833
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  liver development  DNA binding  chromatin binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  chromatin remodeling  central nervous system development  negative regulation of cardiac muscle hypertrophy  negative regulation of histone methylation  histone demethylase activity  histone demethylase activity  histone demethylase activity (H3-trimethyl-K4 specific)  histone H3-K4 demethylation, trimethyl-H3-K4-specific  histone methyltransferase complex  ESC/E(Z) complex  negative regulation of gene expression, epigenetic  negative regulation of transcription, DNA-templated  spleen development  thymus development  stem cell differentiation  positive regulation of histone H3-K9 methylation  negative regulation of cardiac muscle cell proliferation  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  liver development  DNA binding  chromatin binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  chromatin remodeling  central nervous system development  negative regulation of cardiac muscle hypertrophy  negative regulation of histone methylation  histone demethylase activity  histone demethylase activity  histone demethylase activity (H3-trimethyl-K4 specific)  histone H3-K4 demethylation, trimethyl-H3-K4-specific  histone methyltransferase complex  ESC/E(Z) complex  negative regulation of gene expression, epigenetic  negative regulation of transcription, DNA-templated  spleen development  thymus development  stem cell differentiation  positive regulation of histone H3-K9 methylation  negative regulation of cardiac muscle cell proliferation  cellular response to leukemia inhibitory factor  
NDEx NetworkJARID2
Atlas of Cancer Signalling NetworkJARID2
Wikipedia pathwaysJARID2
Orthology - Evolution
OrthoDB3720
GeneTree (enSembl)ENSG00000008083
Phylogenetic Trees/Animal Genes : TreeFamJARID2
Homologs : HomoloGeneJARID2
Homology/Alignments : Family Browser (UCSC)JARID2
Gene fusions - Rearrangements
Fusion : MitelmanJARID2/ATM [6p22.3/11q22.3]  
Fusion : MitelmanJARID2/HSD3B1 [6p22.3/1p12]  
Fusion : MitelmanJARID2/PPP1R10 [6p22.3/6p21.33]  
Fusion : MitelmanKCTD20/JARID2 [6p21.31/6p22.3]  
Fusion : QuiverJARID2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJARID2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JARID2
dbVarJARID2
ClinVarJARID2
MonarchJARID2
1000_GenomesJARID2 
Exome Variant ServerJARID2
GNOMAD BrowserENSG00000008083
Varsome BrowserJARID2
ACMGJARID2 variants
VarityQ92833
Genomic Variants (DGV)JARID2 [DGVbeta]
DECIPHERJARID2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJARID2 
Mutations
ICGC Data PortalJARID2 
TCGA Data PortalJARID2 
Broad Tumor PortalJARID2
OASIS PortalJARID2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICJARID2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DJARID2
Mutations and Diseases : HGMDJARID2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaJARID2
DgiDB (Drug Gene Interaction Database)JARID2
DoCM (Curated mutations)JARID2
CIViC (Clinical Interpretations of Variants in Cancer)JARID2
Cancer3DJARID2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601594   
Orphanet
DisGeNETJARID2
MedgenJARID2
Genetic Testing Registry JARID2
NextProtQ92833 [Medical]
GENETestsJARID2
Target ValidationJARID2
Huge Navigator JARID2 [HugePedia]
ClinGenJARID2 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeJARID2
Protein Interactions : CTDJARID2
Pharm GKB GenePA29995
PharosQ92833
Clinical trialJARID2
Miscellaneous
canSAR (ICR)JARID2
HarmonizomeJARID2
DataMed IndexJARID2
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXJARID2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:28 CEST 2021

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