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JCHAIN (joining chain of multimeric IgA and IgM)

Identity

Alias_namesIGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
Alias_symbol (synonym)IGCJ
JCH
Other alias
HGNC (Hugo) JCHAIN
LocusID (NCBI) 3512
Atlas_Id 64558
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 70655541 and ends at 70666631 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
JCHAIN (4q13.3) / JCHAIN (4q13.3)JCHAIN (4q13.3) / MCM7 (7q22.1)JCHAIN (4q13.3) / PRR18 (6q27)
JCHAIN (4q13.3) / SPPL2B (19p13.3)SHCBP1 (16q11.2) / JCHAIN (4q13.3)SLU7 (5q33.3) / JCHAIN (4q13.3)
ZEB2 (2q22.3) / JCHAIN (4q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)JCHAIN   5713
Cards
Entrez_Gene (NCBI)JCHAIN  3512  joining chain of multimeric IgA and IgM
AliasesIGCJ; IGJ; JCH
GeneCards (Weizmann)JCHAIN
Ensembl hg19 (Hinxton)ENSG00000132465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132465 [Gene_View]  chr4:70655541-70666631 [Contig_View]  JCHAIN [Vega]
ICGC DataPortalENSG00000132465
TCGA cBioPortalJCHAIN
AceView (NCBI)JCHAIN
Genatlas (Paris)JCHAIN
WikiGenes3512
SOURCE (Princeton)JCHAIN
Genetics Home Reference (NIH)JCHAIN
Genomic and cartography
GoldenPath hg38 (UCSC)JCHAIN  -     chr4:70655541-70666631 -  4q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JCHAIN  -     4q13.3   [Description]    (hg19-Feb_2009)
EnsemblJCHAIN - 4q13.3 [CytoView hg19]  JCHAIN - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBIJCHAIN [Mapview hg19]  JCHAIN [Mapview hg38]
OMIM147790   
Gene and transcription
Genbank (Entrez)AK312014 BC038982 BP221304 BP261870 BP418109
RefSeq transcript (Entrez)NM_144646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)JCHAIN
Cluster EST : UnigeneHs.643431 [ NCBI ]
CGAP (NCI)Hs.643431
Alternative Splicing GalleryENSG00000132465
Gene ExpressionJCHAIN [ NCBI-GEO ]   JCHAIN [ EBI - ARRAY_EXPRESS ]   JCHAIN [ SEEK ]   JCHAIN [ MEM ]
Gene Expression Viewer (FireBrowse)JCHAIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3512
GTEX Portal (Tissue expression)JCHAIN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01591   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01591  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01591
Splice isoforms : SwissVarP01591
PhosPhoSitePlusP01591
Domains : Interpro (EBI)Ig_J   
Domain families : Pfam (Sanger)Ig_J_chain (PF15097)   
Domain families : Pfam (NCBI)pfam15097   
Domain structure : Prodom (Prabi Lyon)PD021296 (PD021296)   
Conserved Domain (NCBI)JCHAIN
DMDM Disease mutations3512
Blocks (Seattle)JCHAIN
SuperfamilyP01591
Human Protein AtlasENSG00000132465
Peptide AtlasP01591
HPRD00991
IPIIPI00178926   IPI00964840   IPI00947235   IPI00964000   
Protein Interaction databases
DIP (DOE-UCLA)P01591
IntAct (EBI)P01591
FunCoupENSG00000132465
BioGRIDJCHAIN
STRING (EMBL)JCHAIN
ZODIACJCHAIN
Ontologies - Pathways
QuickGOP01591
Ontology : AmiGOretina homeostasis  adaptive immune response  glomerular filtration  single-stranded DNA binding  antigen binding  extracellular region  extracellular region  extracellular space  receptor-mediated endocytosis  immune response  antibacterial humoral response  IgA binding  protein binding, bridging  phosphatidylcholine binding  positive regulation of protein oligomerization  immunoglobulin receptor binding  immunoglobulin receptor binding  protein homodimerization activity  peptidoglycan binding  innate immune response  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  dimeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  pentameric IgM immunoglobulin complex  hexameric IgM immunoglobulin complex  blood microparticle  
Ontology : EGO-EBIretina homeostasis  adaptive immune response  glomerular filtration  single-stranded DNA binding  antigen binding  extracellular region  extracellular region  extracellular space  receptor-mediated endocytosis  immune response  antibacterial humoral response  IgA binding  protein binding, bridging  phosphatidylcholine binding  positive regulation of protein oligomerization  immunoglobulin receptor binding  immunoglobulin receptor binding  protein homodimerization activity  peptidoglycan binding  innate immune response  leukocyte migration  positive regulation of respiratory burst  extracellular exosome  monomeric IgA immunoglobulin complex  dimeric IgA immunoglobulin complex  secretory IgA immunoglobulin complex  secretory dimeric IgA immunoglobulin complex  pentameric IgM immunoglobulin complex  hexameric IgM immunoglobulin complex  blood microparticle  
NDEx NetworkJCHAIN
Atlas of Cancer Signalling NetworkJCHAIN
Wikipedia pathwaysJCHAIN
Orthology - Evolution
OrthoDB3512
GeneTree (enSembl)ENSG00000132465
Phylogenetic Trees/Animal Genes : TreeFamJCHAIN
HOVERGENP01591
HOGENOMP01591
Homologs : HomoloGeneJCHAIN
Homology/Alignments : Family Browser (UCSC)JCHAIN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJCHAIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JCHAIN
dbVarJCHAIN
ClinVarJCHAIN
1000_GenomesJCHAIN 
Exome Variant ServerJCHAIN
ExAC (Exome Aggregation Consortium)JCHAIN (select the gene name)
Genetic variants : HAPMAP3512
Genomic Variants (DGV)JCHAIN [DGVbeta]
DECIPHERJCHAIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJCHAIN 
Mutations
ICGC Data PortalJCHAIN 
TCGA Data PortalJCHAIN 
Broad Tumor PortalJCHAIN
OASIS PortalJCHAIN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDJCHAIN
BioMutasearch JCHAIN
DgiDB (Drug Gene Interaction Database)JCHAIN
DoCM (Curated mutations)JCHAIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)JCHAIN (select a term)
intoGenJCHAIN
Cancer3DJCHAIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147790   
Orphanet
MedgenJCHAIN
Genetic Testing Registry JCHAIN
NextProtP01591 [Medical]
TSGene3512
GENETestsJCHAIN
Target ValidationJCHAIN
Huge Navigator JCHAIN [HugePedia]
snp3D : Map Gene to Disease3512
BioCentury BCIQJCHAIN
ClinGenJCHAIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3512
Chemical/Pharm GKB GenePA29733
Clinical trialJCHAIN
Miscellaneous
canSAR (ICR)JCHAIN (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineJCHAIN
EVEXJCHAIN
GoPubMedJCHAIN
iHOPJCHAIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:11:27 CEST 2017

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