JMY (junction mediating and regulatory protein, p53 cofactor)

2003-02-01  

Identity

HGNC
JMY
LOCATION
5q14.1
LOCUSID
133746
ALIAS
WHAMM2,WHDC1L3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 133746
MIM: 604279
HGNC: 28916
Ensembl: ENSG00000152409

Variants:

dbSNP: 133746
ClinVar: 133746
TCGA: ENSG00000152409
COSMIC: JMY

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152409ENST00000396137Q8N9B5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192873772009p53-cofactor JMY is a multifunctional actin nucleation factor.107
183988212008Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients.44
198977262009A transcription co-factor integrates cell adhesion and motility with the p53 response.33
262239512015Actin nucleation by WH2 domains at the autophagosome.29
222624582012Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY.23
219652852011The actin nucleation factor JMY is a negative regulator of neuritogenesis.19
216252182011Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.16
240693482013JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study.10
304203552019LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.7
252804612014JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.5

Citation

Dessen P

JMY (junction mediating and regulatory protein, p53 cofactor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41043/jmy