JPT1 (Jupiter microtubule associated homolog 1)

2017-04-01  

Identity

HGNC
JPT1
LOCATION
17q25.1
LOCUSID
51155
ALIAS
ARM2,HN1,HN1A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51155
HGNC: 14569
Ensembl: ENSG00000189159

Variants:

dbSNP: 51155
ClinVar: 51155
TCGA: ENSG00000189159
COSMIC: JPT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189159ENST00000304834F2Z3M5
ENSG00000189159ENST00000356033Q9UK76
ENSG00000189159ENST00000409753Q9UK76
ENSG00000189159ENST00000470924Q9UK76
ENSG00000189159ENST00000476258Q9UK76
ENSG00000189159ENST00000481647Q9UK76
ENSG00000189159ENST00000482348Q9UK76
ENSG00000189159ENST00000580380J3KSH8
ENSG00000189159ENST00000581874J3KT51

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
254503652014MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.35
284903342017HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity.10
213235782011Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.8
191454782009Hematopoietic- and neurologic-expressed sequence 1 expression in the murine GL261 and high-grade human gliomas.7
221554082012Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells.7
251694222015HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells.6

Citation

Dessen P

JPT1 (Jupiter microtubule associated homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56784/jpt1