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JTB (jumping translocation breakpoint)

Identity

Alias_symbol (synonym)hJT
PAR
Other aliasHJTB
HSPC222
HGNC (Hugo) JTB
LocusID (NCBI) 10899
Atlas_Id 41044
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153974269 and ends at 153977674 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JTB (1q21.3) / BTG1 (12q21.33)JTB (1q21.3) / CYP1B1 (2p22.2)JTB (1q21.3) / JTB (1q21.3)
JTB (1q21.3) / SNAPIN (1q21.3)JTB 1q21.3 / CYP1B1 2p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p36;q21) in Non Hodgkin Lymphoma

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;2)(q21;p22) JTB/CYP1B1

External links

Nomenclature
HGNC (Hugo)JTB   6201
Cards
Entrez_Gene (NCBI)JTB  10899  jumping translocation breakpoint
AliasesHJTB; HSPC222; PAR; hJT
GeneCards (Weizmann)JTB
Ensembl hg19 (Hinxton)ENSG00000143543 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143543 [Gene_View]  ENSG00000143543 [Sequence]  chr1:153974269-153977674 [Contig_View]  JTB [Vega]
ICGC DataPortalENSG00000143543
TCGA cBioPortalJTB
AceView (NCBI)JTB
Genatlas (Paris)JTB
WikiGenes10899
SOURCE (Princeton)JTB
Genetics Home Reference (NIH)JTB
Genomic and cartography
GoldenPath hg38 (UCSC)JTB  -     chr1:153974269-153977674 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JTB  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathJTB - 1q21.3 [CytoView hg19]  JTB - 1q21.3 [CytoView hg38]
Genome Data Viewer NCBIJTB [Mapview hg19]  
OMIM604671   
Gene and transcription
Genbank (Entrez)AB016488 AF115850 AF131797 AF151056 AK312106
RefSeq transcript (Entrez)NM_006694
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)JTB
Alternative Splicing GalleryENSG00000143543
Gene ExpressionJTB [ NCBI-GEO ]   JTB [ EBI - ARRAY_EXPRESS ]   JTB [ SEEK ]   JTB [ MEM ]
Gene Expression Viewer (FireBrowse)JTB [ Firebrowse - Broad ]
GenevisibleExpression of JTB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10899
GTEX Portal (Tissue expression)JTB
Human Protein AtlasENSG00000143543-JTB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76095   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76095  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76095
Splice isoforms : SwissVarO76095
PhosPhoSitePlusO76095
Domains : Interpro (EBI)JTB   
Domain families : Pfam (Sanger)JTB (PF05439)   
Domain families : Pfam (NCBI)pfam05439   
Conserved Domain (NCBI)JTB
DMDM Disease mutations10899
PDB (RSDB)2KJX   
PDB Europe2KJX   
PDB (PDBSum)2KJX   
PDB (IMB)2KJX   
Structural Biology KnowledgeBase2KJX   
SCOP (Structural Classification of Proteins)2KJX   
CATH (Classification of proteins structures)2KJX   
SuperfamilyO76095
Human Protein Atlas [tissue]ENSG00000143543-JTB [tissue]
Peptide AtlasO76095
HPRD05240
IPIIPI00008833   IPI00000912   
Protein Interaction databases
DIP (DOE-UCLA)O76095
IntAct (EBI)O76095
FunCoupENSG00000143543
BioGRIDJTB
STRING (EMBL)JTB
ZODIACJTB
Ontologies - Pathways
QuickGOO76095
Ontology : AmiGOmitotic cell cycle  mitotic cytokinesis  mitotic cytokinesis  cytoplasm  cytoplasm  mitochondrion  centrosome  centrosome  spindle  spindle  integral component of plasma membrane  apoptotic process  membrane  protein kinase binding  midbody  midbody  positive regulation of protein kinase activity  
Ontology : EGO-EBImitotic cell cycle  mitotic cytokinesis  mitotic cytokinesis  cytoplasm  cytoplasm  mitochondrion  centrosome  centrosome  spindle  spindle  integral component of plasma membrane  apoptotic process  membrane  protein kinase binding  midbody  midbody  positive regulation of protein kinase activity  
NDEx NetworkJTB
Atlas of Cancer Signalling NetworkJTB
Wikipedia pathwaysJTB
Orthology - Evolution
OrthoDB10899
GeneTree (enSembl)ENSG00000143543
Phylogenetic Trees/Animal Genes : TreeFamJTB
HOGENOMO76095
Homologs : HomoloGeneJTB
Homology/Alignments : Family Browser (UCSC)JTB
Gene fusions - Rearrangements
Fusion : MitelmanJTB/CYP1B1 [1q21.3/2p22.2]  
Fusion PortalJTB 1q21.3 CYP1B1 2p22.2 PRAD
Fusion Cancer (Beijing)JTB [1q21.3]  -  BTG1 [12q21.33]  [FUSC000359]
Fusion : QuiverJTB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJTB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JTB
dbVarJTB
ClinVarJTB
1000_GenomesJTB 
Exome Variant ServerJTB
GNOMAD BrowserENSG00000143543
Varsome BrowserJTB
Genetic variants : HAPMAP10899
Genomic Variants (DGV)JTB [DGVbeta]
DECIPHERJTB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJTB 
Mutations
ICGC Data PortalJTB 
TCGA Data PortalJTB 
Broad Tumor PortalJTB
OASIS PortalJTB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICJTB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DJTB
Mutations and Diseases : HGMDJTB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect JTB
DgiDB (Drug Gene Interaction Database)JTB
DoCM (Curated mutations)JTB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)JTB (select a term)
intoGenJTB
Cancer3DJTB (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604671   
Orphanet
DisGeNETJTB
MedgenJTB
Genetic Testing Registry JTB
NextProtO76095 [Medical]
TSGene10899
GENETestsJTB
Open Targets GeneticsENSG00000143543  [validation]
snp3D : Map Gene to Disease10899
BioCentury BCIQJTB
ClinGenJTB
Clinical trials, drugs, therapy
Protein Interactions : CTD10899
Pharm GKB GenePA30003
Clinical trialJTB
Miscellaneous
canSAR (ICR)JTB (select the gene name)
HarmonizomeJTB
DataMed IndexJTB
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineJTB
EVEXJTB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 19:54:06 CEST 2020
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