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KALRN (kalirin RhoGEF kinase)

Identity

Alias (NCBI)ARHGEF24
CHD5
CHDS5
DUET
DUO
HAPIP
TRAD
HGNC (Hugo) KALRN
HGNC Alias symbduo
Hs.8004
TRAD
DUET
Kalirin
ARHGEF24
HGNC Alias nameserine/threonine kinase with Dbl and pleckstrin homology domains
HGNC Previous nameHAPIP
HGNC Previous namehuntingtin-associated protein interacting protein (duo)
LocusID (NCBI) 8997
Atlas_Id 56634
Location 3q21.2  [Link to chromosome band 3q21]
Location_base_pair Starts at 124584658 and ends at 124726325 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ECT2 (3q26.31) / KALRN (3q21.2)KALRN (3q21.2) / ELF3 (1q32.1)KALRN (3q21.2) / PRB4 (12p13.2)
KPNB1 (17q21.32) / KALRN (3q21.2)NLK (17q11.2) / KALRN (3q21.2)RYK (3q22.2) / KALRN (3q21.2)
UMPS (3q21.2) / KALRN (3q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KALRN   4814
Cards
Entrez_Gene (NCBI)KALRN    kalirin RhoGEF kinase
AliasesARHGEF24; CHD5; CHDS5; DUET; 
DUO; HAPIP; TRAD
GeneCards (Weizmann)KALRN
Ensembl hg19 (Hinxton)ENSG00000160145 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160145 [Gene_View]  ENSG00000160145 [Sequence]  chr3:124584658-124726325 [Contig_View]  KALRN [Vega]
ICGC DataPortalENSG00000160145
TCGA cBioPortalKALRN
AceView (NCBI)KALRN
Genatlas (Paris)KALRN
SOURCE (Princeton)KALRN
Genetics Home Reference (NIH)KALRN
Genomic and cartography
GoldenPath hg38 (UCSC)KALRN  -     chr3:124584658-124726325 +  3q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KALRN  -     3q21.2   [Description]    (hg19-Feb_2009)
GoldenPathKALRN - 3q21.2 [CytoView hg19]  KALRN - 3q21.2 [CytoView hg38]
ImmunoBaseENSG00000160145
Genome Data Viewer NCBIKALRN [Mapview hg19]  
OMIM604605   
Gene and transcription
Genbank (Entrez)AB011422 AI024603 AK022394 AK096580 AK123068
RefSeq transcript (Entrez)NM_001024660 NM_001322988 NM_001322989 NM_001322990 NM_001322991 NM_001322992 NM_001322993 NM_001322994 NM_001322995 NM_001322996 NM_001322997 NM_001322998 NM_001322999 NM_001323000 NM_001323001 NM_001388412 NM_001388413 NM_001388414 NM_001388415 NM_001388416 NM_001388417 NM_001388418 NM_001388419 NM_003947 NM_007064
Consensus coding sequences : CCDS (NCBI)KALRN
Gene ExpressionKALRN [ NCBI-GEO ]   KALRN [ EBI - ARRAY_EXPRESS ]   KALRN [ SEEK ]   KALRN [ MEM ]
Gene Expression Viewer (FireBrowse)KALRN [ Firebrowse - Broad ]
GenevisibleExpression of KALRN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8997
GTEX Portal (Tissue expression)KALRN
Human Protein AtlasENSG00000160145-KALRN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60229   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60229  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60229
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO60229
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    DH_2 (PS50010)    FN3 (PS50853)    IG_LIKE (PS50835)    PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)CRAL-TRIO_dom    CRAL-TRIO_dom_sf    DBL_dom_sf    DH-domain    FN3_dom    FN3_sf    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kalirin/TRIO    Kinase-like_dom_sf    PH-like_dom_sf    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    SH3-like_dom_sf    SH3_domain    Spectrin/alpha-actinin    Spectrin_repeat   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    fn3 (PF00041)    I-set (PF07679)    PH (PF00169)    Pkinase (PF00069)    RhoGEF (PF00621)    Spectrin (PF00435)   
Domain families : Pfam (NCBI)pfam13716    pfam00041    pfam07679    pfam00169    pfam00069    pfam00621    pfam00435   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  PH (SM00233)  RhoGEF (SM00325)  S_TKc (SM00220)  SEC14 (SM00516)  SH3 (SM00326)  SPEC (SM00150)  
Conserved Domain (NCBI)KALRN
PDB (RSDB)5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
PDB Europe5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
PDB (PDBSum)5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
PDB (IMB)5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
Structural Biology KnowledgeBase5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
SCOP (Structural Classification of Proteins)5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
CATH (Classification of proteins structures)5QQD    5QQE    5QQF    5QQG    5QQH    5QQI    5QQJ    5QQK    5QQL    5QQM    5QQN    5QU9   
SuperfamilyO60229
AlphaFold pdb e-kbO60229   
Human Protein Atlas [tissue]ENSG00000160145-KALRN [tissue]
Protein Interaction databases
DIP (DOE-UCLA)O60229
IntAct (EBI)O60229
BioGRIDKALRN
STRING (EMBL)KALRN
ZODIACKALRN
Ontologies - Pathways
QuickGOO60229
Ontology : AmiGOprotein serine/threonine kinase activity  guanyl-nucleotide exchange factor activity  ATP binding  nucleoplasm  cytosol  cytosol  protein phosphorylation  signal transduction  G protein-coupled receptor signaling pathway  nervous system development  axon guidance  central nervous system development  actin cytoskeleton  vesicle-mediated transport  intracellular signal transduction  positive regulation of apoptotic process  metal ion binding  ephrin receptor signaling pathway  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  extracellular exosome  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  guanyl-nucleotide exchange factor activity  ATP binding  nucleoplasm  cytosol  cytosol  protein phosphorylation  signal transduction  G protein-coupled receptor signaling pathway  nervous system development  axon guidance  central nervous system development  actin cytoskeleton  vesicle-mediated transport  intracellular signal transduction  positive regulation of apoptotic process  metal ion binding  ephrin receptor signaling pathway  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  extracellular exosome  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkKALRN
Atlas of Cancer Signalling NetworkKALRN
Wikipedia pathwaysKALRN
Orthology - Evolution
OrthoDB8997
GeneTree (enSembl)ENSG00000160145
Phylogenetic Trees/Animal Genes : TreeFamKALRN
Homologs : HomoloGeneKALRN
Homology/Alignments : Family Browser (UCSC)KALRN
Gene fusions - Rearrangements
Fusion : QuiverKALRN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKALRN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KALRN
dbVarKALRN
ClinVarKALRN
MonarchKALRN
1000_GenomesKALRN 
Exome Variant ServerKALRN
GNOMAD BrowserENSG00000160145
Varsome BrowserKALRN
ACMGKALRN variants
VarityO60229
Genomic Variants (DGV)KALRN [DGVbeta]
DECIPHERKALRN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKALRN 
Mutations
ICGC Data PortalKALRN 
TCGA Data PortalKALRN 
Broad Tumor PortalKALRN
OASIS PortalKALRN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKALRN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKALRN
Mutations and Diseases : HGMDKALRN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKALRN
DgiDB (Drug Gene Interaction Database)KALRN
DoCM (Curated mutations)KALRN
CIViC (Clinical Interpretations of Variants in Cancer)KALRN
Cancer3DKALRN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604605   
Orphanet
DisGeNETKALRN
MedgenKALRN
Genetic Testing Registry KALRN
NextProtO60229 [Medical]
GENETestsKALRN
Target ValidationKALRN
Huge Navigator KALRN [HugePedia]
ClinGenKALRN
Clinical trials, drugs, therapy
MyCancerGenomeKALRN
Protein Interactions : CTDKALRN
Pharm GKB GenePA29189
PharosO60229
Clinical trialKALRN
Miscellaneous
canSAR (ICR)KALRN
HarmonizomeKALRN
DataMed IndexKALRN
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKALRN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:32 CEST 2021

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