KALRN (kalirin RhoGEF kinase)

2016-12-01  

Identity

HGNC
LOCATION
3q21.2
LOCUSID
ALIAS
ARHGEF24,CHD5,CHDS5,DUET,DUO,HAPIP,TRAD
FUSION GENES

Other Information

Locus ID:

NCBI: 8997
MIM: 604605
HGNC: 4814
Ensembl: ENSG00000160145

Variants:

dbSNP: 8997
ClinVar: 8997
TCGA: ENSG00000160145
COSMIC: KALRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160145ENST00000240874O60229
ENSG00000160145ENST00000291478O60229
ENSG00000160145ENST00000354186H7BXZ5
ENSG00000160145ENST00000360013O60229
ENSG00000160145ENST00000439170H7C1X7
ENSG00000160145ENST00000448253H7C0I9
ENSG00000160145ENST00000454902C9J1B4
ENSG00000160145ENST00000460856C9IZQ6
ENSG00000160145ENST00000483658A0A0D9SGH1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188390572008Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.139
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
173570712007Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.53
181997702008Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons.51
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
210418342012Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.40
210418342012Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.40
176403722007Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation.39
178511882007Kalirin is under-expressed in Alzheimer's disease hippocampus.39
189534342008Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer.31

Citation

Dessen P

KALRN (kalirin RhoGEF kinase)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56634/kalrn