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KANK1 (KN motif and ankyrin repeat domains 1)

Identity

Alias (NCBI)ANKRD15
CPSQ2
KANK
HGNC (Hugo) KANK1
HGNC Alias symbKIAA0172
KANK
HGNC Previous nameANKRD15
HGNC Previous nameankyrin repeat domain 15
LocusID (NCBI) 23189
Atlas_Id 645
Location 9p24.3  [Link to chromosome band 9p24]
Location_base_pair Starts at 706677 and ends at 746106 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ESCO1 (18q11.2) / KANK1 (9p24.3)IGFN1 (1q32.1) / KANK1 (9p24.3)KANK1 (9p24.3) / DOCK8 (9p24.3)
KANK1 (9p24.3) / MCM3AP-AS1 (21q22.3)KANK1 (9p24.3) / PDGFRB (5q32)KANK1 (9p24.3) / TPD52L3 (9p24.1)
KANK1 (9p24.3) / UHRF2 (9p24.1)PAX5 (9p13.2) / KANK1 (9p24.3)PIK3R1 (5q13.1) / KANK1 (9p24.3)
ESCO1 18q11.2 / KANK1 9p24.3IGFN1 1q32.1 / KANK1 9p24.3KANK1 9p24.3 / DOCK8 9p24.3
KANK1 9p24.3 / TPD52L3 9p24.1KANK1 9p24.3 / UHRF2 9p24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(5;9)(q32;p24) KANK1/PDGFRB
t(9;9)(p13;p24) PAX5/KANK1
t(9;11)(p24;q23) CBL/KANK1


External links

 

Nomenclature
HGNC (Hugo)KANK1   19309
Cards
Entrez_Gene (NCBI)KANK1    KN motif and ankyrin repeat domains 1
AliasesANKRD15; CPSQ2; KANK
GeneCards (Weizmann)KANK1
Ensembl hg19 (Hinxton)ENSG00000107104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107104 [Gene_View]  ENSG00000107104 [Sequence]  chr9:706677-746106 [Contig_View]  KANK1 [Vega]
ICGC DataPortalENSG00000107104
TCGA cBioPortalKANK1
AceView (NCBI)KANK1
Genatlas (Paris)KANK1
SOURCE (Princeton)KANK1
Genetics Home Reference (NIH)KANK1
Genomic and cartography
GoldenPath hg38 (UCSC)KANK1  -     chr9:706677-746106 +  9p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KANK1  -     9p24.3   [Description]    (hg19-Feb_2009)
GoldenPathKANK1 - 9p24.3 [CytoView hg19]  KANK1 - 9p24.3 [CytoView hg38]
ImmunoBaseENSG00000107104
Genome Data Viewer NCBIKANK1 [Mapview hg19]  
OMIM607704   612900   
Gene and transcription
Genbank (Entrez)AB205106 AB205107 AB205108 AB205109 AB205110
RefSeq transcript (Entrez)NM_001256876 NM_001256877 NM_001354331 NM_001354332 NM_001354333 NM_001354334 NM_001354335 NM_001354336 NM_001354337 NM_001354338 NM_001354339 NM_001354340 NM_001354341 NM_001354342 NM_001354343 NM_001354344 NM_015158 NM_153186
Consensus coding sequences : CCDS (NCBI)KANK1
Gene ExpressionKANK1 [ NCBI-GEO ]   KANK1 [ EBI - ARRAY_EXPRESS ]   KANK1 [ SEEK ]   KANK1 [ MEM ]
Gene Expression Viewer (FireBrowse)KANK1 [ Firebrowse - Broad ]
GenevisibleExpression of KANK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23189
GTEX Portal (Tissue expression)KANK1
Human Protein AtlasENSG00000107104-KANK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14678   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14678  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14678
PhosPhoSitePlusQ14678
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    KN_motif   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    KN_motif (PF12075)   
Domain families : Pfam (NCBI)pfam12796    pfam12075   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)KANK1
PDB (RSDB)5YBJ    5YBU   
PDB Europe5YBJ    5YBU   
PDB (PDBSum)5YBJ    5YBU   
PDB (IMB)5YBJ    5YBU   
Structural Biology KnowledgeBase5YBJ    5YBU   
SCOP (Structural Classification of Proteins)5YBJ    5YBU   
CATH (Classification of proteins structures)5YBJ    5YBU   
SuperfamilyQ14678
AlphaFold pdb e-kbQ14678   
Human Protein Atlas [tissue]ENSG00000107104-KANK1 [tissue]
HPRD09651
Protein Interaction databases
DIP (DOE-UCLA)Q14678
IntAct (EBI)Q14678
BioGRIDKANK1
STRING (EMBL)KANK1
ZODIACKANK1
Ontologies - Pathways
QuickGOQ14678
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  plasma membrane  plasma membrane  beta-catenin binding  cell population proliferation  negative regulation of neuron projection development  actin cytoskeleton organization  positive regulation of Wnt signaling pathway  negative regulation of cell migration  negative regulation of actin filament polymerization  negative regulation of actin filament polymerization  negative regulation of actin filament polymerization  ruffle membrane  regulation of Rho protein signal transduction  negative regulation of Rho protein signal transduction  negative regulation of insulin receptor signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of wound healing  glomerular visceral epithelial cell migration  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  regulation of establishment of cell polarity  negative regulation of lamellipodium morphogenesis  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  plasma membrane  plasma membrane  beta-catenin binding  cell population proliferation  negative regulation of neuron projection development  actin cytoskeleton organization  positive regulation of Wnt signaling pathway  negative regulation of cell migration  negative regulation of actin filament polymerization  negative regulation of actin filament polymerization  negative regulation of actin filament polymerization  ruffle membrane  regulation of Rho protein signal transduction  negative regulation of Rho protein signal transduction  negative regulation of insulin receptor signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of wound healing  glomerular visceral epithelial cell migration  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  regulation of establishment of cell polarity  negative regulation of lamellipodium morphogenesis  
NDEx NetworkKANK1
Atlas of Cancer Signalling NetworkKANK1
Wikipedia pathwaysKANK1
Orthology - Evolution
OrthoDB23189
GeneTree (enSembl)ENSG00000107104
Phylogenetic Trees/Animal Genes : TreeFamKANK1
Homologs : HomoloGeneKANK1
Homology/Alignments : Family Browser (UCSC)KANK1
Gene fusions - Rearrangements
Fusion : MitelmanESCO1/KANK1 [18q11.2/9p24.3]  
Fusion : MitelmanIGFN1/KANK1 [1q32.1/9p24.3]  
Fusion : MitelmanKANK1/DOCK8 [9p24.3/9p24.3]  
Fusion : MitelmanKANK1/PDGFRB [9p24.3/5q32]  
Fusion : MitelmanKANK1/TPD52L3 [9p24.3/9p24.1]  
Fusion : MitelmanKANK1/UHRF2 [9p24.3/9p24.1]  
Fusion : MitelmanPIK3R1/KANK1 [5q13.1/9p24.3]  
Fusion : QuiverKANK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKANK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KANK1
dbVarKANK1
ClinVarKANK1
MonarchKANK1
1000_GenomesKANK1 
Exome Variant ServerKANK1
GNOMAD BrowserENSG00000107104
Varsome BrowserKANK1
ACMGKANK1 variants
VarityQ14678
Genomic Variants (DGV)KANK1 [DGVbeta]
DECIPHERKANK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKANK1 
Mutations
ICGC Data PortalKANK1 
TCGA Data PortalKANK1 
Broad Tumor PortalKANK1
OASIS PortalKANK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKANK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKANK1
Mutations and Diseases : HGMDKANK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKANK1
DgiDB (Drug Gene Interaction Database)KANK1
DoCM (Curated mutations)KANK1
CIViC (Clinical Interpretations of Variants in Cancer)KANK1
Cancer3DKANK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607704    612900   
Orphanet18688   
DisGeNETKANK1
MedgenKANK1
Genetic Testing Registry KANK1
NextProtQ14678 [Medical]
GENETestsKANK1
Target ValidationKANK1
Huge Navigator KANK1 [HugePedia]
ClinGenKANK1
Clinical trials, drugs, therapy
MyCancerGenomeKANK1
Protein Interactions : CTDKANK1
Pharm GKB GenePA162392554
PharosQ14678
Clinical trialKANK1
Miscellaneous
canSAR (ICR)KANK1
HarmonizomeKANK1
DataMed IndexKANK1
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKANK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:14:32 CEST 2021

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